4 research outputs found

    One-Pot Multi-Tracer Synthesis of Novel <sup>18</sup>F‚ÄĎLabeled PET Imaging Agents

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    <sup>18</sup>F labeled phosphonium salts are increasingly important molecular probes for targeting the mitochondrial membrane potential depletion during apoptosis and for detecting myocardial perfusion deficit. Here, we introduce three new tracers, [<sup>18</sup>F]­MitoPhos_04, [<sup>18</sup>F]­MitoPhos_05, and [<sup>18</sup>F]­MitoPhos_07, that have the potential to act as mitochondrial imaging agents. Moreover, they have the added advantage of being synthesized in the same reaction vial from one radiolabeled synthon, demonstrating a new approach to synthesizing multiple tracers in one-pot, which is a highly useful means for increasing the throughput of radiotracer development. The radiosynthesis of the tracers was carried out on a fully automated system via a facile two-step reaction. Utilizing the radiolabeling of an ethyl azide, a copper-mediated 1,3-cycloaddition reaction and isolation via semiprep high-performance liquid chromatography (HPLC) allowed for the simultaneous synthesis of two or three tracers with a total synthesis time of less than 1 h

    Lipid hydrolysis by raclopride tartrate

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    <p>HPLC data showing the rates of lipid ester hydrolysis by a zwitterionic D2 antagonic, raclopride tartrate. Data is expressed as the molar percentage of lyso-lipid in the sample at the time of quenching (by freeze-drying of aliquot): fatty acid signal was not easily quantifiable. However, linear increase of lyso-lipid signal meant fatty acid concentration could be assumed to be equal.</p> <p>System was deliberately chosen to deliver slow rates to make observation, sampling and quantitative analysis possible. This was generated as a follow-up to the original discovery, available at http://www.ncbi.nlm.nih.gov/pubmed/16973478.</p

    The Spectroscopic Study of Cold Ions in Plasma and Ion Trap

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    %ID/g for the thyroid (upper), salivary glands (centre) and stomach (lower) in BALB/c mice estimated by ex vivo biodistribution (open circles) and PET ROI analysis (filled squares) at varying doses of 18/19F-BF4 √ʬą¬í. (PDF 15.7 KB)