105 research outputs found

    Uncertainty analysis of life cycle assessment of asphalt surfacings

    No full text
    The Life Cycle Assessment (LCA) of asphalt pavements are associated with significant uncertainty resulting from variability in the quantity and impact of individual components, the quality of data for each component, and variability of asphalt durability. This study presents a framework to quantify and incorporate the uncertainty of LCA and asphalt durability data into LCA of asphalt surfacings. The suggested framework includes: estimating the uncertainty of asphalt production processes by the pedigree matrix method, conducting a deterministic LCA, applying Monte Carlo Simulation (MCS) to estimate the probability density functions (PDFs) of the considered impacts using the uncertainty data, deterministic solution, and asphalt durability. This framework was applied to six asphalt mixtures; the results show that there is significant uncertainty in the processes that contribute to the environmental impacts. They also showed that considering asphalt durability and its uncertainty is critical and can significantly change the results and interpretation of LCA

    Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

    Get PDF
    Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson‚Äôs disease (PD) and Alzheimer‚Äôs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aő≤42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

    Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle‚ÄĒA Narrative Review

    No full text
    Canine atopic dermatitis (cAD) is a common and distressing skin condition in dogs, affecting up to 30% of the canine population. It not only impacts their quality of life but also that of their owners. Like human atopic dermatitis (hAD), cAD has a complex pathogenesis, including genetic and environmental factors. Current treatments focus on managing clinical signs, but they can be costly and have limitations. This article emphasizes the importance of preventing cAD from developing in the first place. Understanding the role of the skin’s protective barrier is crucial, as its dysfunction plays a vital role in both hAD and cAD. hAD prevention studies have shown promising results in enhancing the skin barrier, but more research is needed to support more robust conclusions. While hAD primary prevention is currently a focal point of intensive investigation in human medicine, research on cAD primary prevention remains under-researched and almost non-existent. Pioneering effective prevention strategies for cAD holds immense potential to enhance the quality of life for both dogs and their owners. Additionally, it bears the promise of a translational impact on human research. Hence, further exploration of this crucial topic is not only relevant but also timely and imperative, warranting support and encouragement

    Incidencia de los gastos de cese laboral en la determinaci√≥n del Impuesto a la Renta del sector textil de Lima Metropolitana, a√Īos 2020-2021

    Get PDF
    La presente investigaci√≥n tiene como objetivo determinar la incidencia de los gastos de cese laboral en la determinaci√≥n del Impuesto a la Renta del sector textil de Lima Metropolitana, a√Īos 2020-2021. La investigaci√≥n busca indagar el impacto de la deducci√≥n o reparo de los incentivos para el cese laboral en la determinaci√≥n del Impuesto a la Renta en un ejercicio fiscal, considerando la normativa tributaria y los criterios y posturas adoptadas por la Administraci√≥n Tributaria y el Tribunal Fiscal sobre el incentivo de la suma graciosa, el incentivo del art√≠culo 1288 del C√≥digo Civil y el incentivo para constituir una nueva empresa. La investigaci√≥n se organiza en cinco cap√≠tulos: cap√≠tulo I Marco Te√≥rico, desarrolla las investigaciones precedentes relacionadas al tema y define conceptos de las variables y dimensiones; en el cap√≠tulo II Plan de Investigaci√≥n, se define el problema, los objetivos e hip√≥tesis generales y espec√≠ficos, en el cap√≠tulo III Metodolog√≠a del Trabajo, se define el dise√Īo y tipo de investigaci√≥n, las herramientas para la recolecci√≥n de datos y el tama√Īo de la muestra, en el cap√≠tulo IV Desarrollo de la Investigaci√≥n, se desarrolla los resultados obtenidos en las entrevistas en profundidad y las encuestas, tambi√©n se aplica un caso pr√°ctico para cada gasto de incentivo al cese laboral. Finalmente, en el cap√≠tulo V An√°lisis de Resultados, se desarrolla el an√°lisis de las entrevistas en profundidad, las encuestas y los casos pr√°cticos y se constata la aprobaci√≥n de las hip√≥tesis.The objective of this investigation is to determine the incidence of labor cessation expenses in the determination of the income tax of companies in the textile sector affiliated to the Chamber of Commerce of Lima, years 2020-2021. The investigation seeks to investigate the impact of the deduction or repair of incentives for termination of employment in the determination of income tax in a fiscal year, considering the tax regulations and the criteria and positions adopted by the tax administration and the tax court on the incentive of the graceful sum, the incentive of article 1288 of the civil code and the incentive to establish a new company. The research is organized into five chapters: Chapter I Theoretical Framework, develops previous research related to the subject and defines concepts of variables and dimensions; in chapter II Research Plan, the problem is defined, the objectives and general and specific hypotheses, in chapter III Work Methodology, the design and type of research, the tools for data collection and the size of the research are defined. sample, in chapter IV Research Development, the results obtained in in-depth interviews and surveys are developed, a practical case is also applied for each incentive expense for termination of employment. Finally, in chapter V Analysis of Results, the analysis of in-depth interviews, surveys and practical cases is developed and the approval of the hypotheses is verified.Tesi

    Ativismo feminista e o corpo performativo: a possibilidade de intervenção no panorama artístico português (1970-2020)

    Get PDF
    A presente disserta√ß√£o tem como objetivo integrar a performatividade em propostas de cariz ativista capazes de problematizar os modelos de representa√ß√£o sexista impostos ao corpo feminino. Inscrito numa din√Ęmica de desejo faloc√™ntrico, o corpo da mulher tem sido o meio pelo qual o sistema patriarcal controla diversos dos seus ideais, mantendo a mulher associada √† corporalidade, por oposi√ß√£o ao homem associado ao dom√≠nio do intelecto. Atrav√©s da utiliza√ß√£o do corpo na pr√°tica performativa, a mulher desafia as convencionais representa√ß√Ķes de g√©nero, revelando um conjunto de dissid√™ncias sociais e culturais inscritas na corporalidade feminina. Nesta perspetiva, num primeiro momento, recorremos ao legado deixado pela gera√ß√£o de feministas norte-americanas da d√©cada de 1970, para refletir sobre as propostas de artistas que ao desafiarem as convencionais representa√ß√Ķes de g√©nero reconfiguraram a pr√≥pria imagem da mulher. Na segunda parte da disserta√ß√£o, abordando especificamente o contexto nacional, concentramo-nos no trabalho de Vera Mantero, Rita GT e do coletivo GATA para analisar, respetivamente, as rela√ß√Ķes da performance com o corpo enquanto superf√≠cie de inscri√ß√£o pol√≠tica e social; a performance enquanto meio de ocupa√ß√£o do espa√ßo museol√≥gico e do espa√ßo urbano, problematizando os valores presentes na edifica√ß√£o destes mesmos espa√ßos; e por fim, a integra√ß√£o da performance ativista em propostas de car√°cter coletivista e participativo.This dissertation aims to integrate the performativity in activist practices, capable of problematizing the models of sexist representation imposed on the female body. Inscribed in a dynamic of phallocentric desire, the woman's body has been the means by which the patriarchal system controls several of his ideals, keeping the woman associated with corporality, in opposition to the man represented by the domain of the intellect. By using the body in performative practices, women challenge conventional gender representations by revealing a set of social and cultural dissents inscribed in female corporality. Therefore, in a first moment, we used the analysis of the legacy left by the generation of american feminists of the 1970s, to reflect on the proposals of artists that challenge the conventional gender representations in order to reconfigure the woman's image. In the second part of this dissertation, specifically addressing the national context, we focus on the work of Vera Mantero, Rita GT and the collective GATA to analyse, respectively, the relations of performance with the body as a surface of political and social inscription; performance as a means of occupation of the museological space and urban space, problematizing the values present in the construction of these spaces; and finally, the integration of activist performance into collectivist and participatory practices

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    Get PDF
    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE őĶ4 allele

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    Get PDF
    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE őĶ4 allele

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    No full text
    Characterization of the genetic landscape of Alzheimer‚Äôs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‚Äėproxy‚Äô AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE őĶ4 allele

    New insights into the genetic etiology of Alzheimer’s disease and related dementias