134 research outputs found

    Infection par le VHC et atteinte rénale

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    International audienc

    Use of direct-acting agents for hepatitis C virus-positive kidney transplant candidates and kidney transplant recipients

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    International audienceIn some parts of the world, hepatitis C virus (HCV) infection remains a huge problem for kidney transplant candidates and kidney transplant (KT) recipients. Until 2 years ago, anti‐HCV treatment for the general population relied on pegylated alpha‐interferon plus ribavirin, but led to a sustained viral response (SVR) in 90%, whatever the patient's HCV genotype. In KT patients, sofosbuvir‐based therapy is associated with a SVR at nearly 100% in patients with a HCV genotype‐1 infection, with almost no side effects and only mild interference with immunosuppressive drugs. Most HCV(+) patients with ESRD are genotype 1: in that setting, a recent study reported that the association of grazoprevir/elbasvir 100/50 mg/day led to a SVR of nearly 95% with very few side effects. Thus, it is concluded that DAAs can be safely used and lead to results in KT candidates and KT patients that are as good as those observed in the nonrenal population

    Association between female sex, IL28B genotype, but also DQB1*0301 allele and the outcome of acute hepatitis C virus infection

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    International audienceWe thank Grebely et al.1 for their recent InC study confirming that the IL28B genotype and female sex are associated with the spontaneous clearance of hepatitis C virus (HCV). However, we and others showed that spontaneous HCV resolution is associated with another genetic factor more than 10 years ago. This factor is the DQB1*0301 allele of the major histocompatibility complex class II.2 The IL28B genotype was shown to be the most important factor associated with a sustained virologic response to pegylated-interferon ribavirin therapy3 and also with the spontaneous outcome of HCV infection.4 However, the study4 showing that genetic variations in IL28B is associated with spontaneous clearance of HCV focused on a single nucleotide polymorphism and was not a genome-wide association study (GWAS). A new multicenter collaborative study5 on 919 North American and European subjects whose HCV was resolved spontaneously was conducted to explain the conflicting results.2, 4 It was shown5 that IL28B rs12979860 and DQB1*0301 rs4272729 alleles were independently associated with the spontaneous resolution of HCV. Surprisingly, these results are not discussed by Grebely et al