A Simple, Automatic Means of Designing a Conversion Table for Expressing Laboratory Results in the International System of Units (SI)

Peer Reviewe

Understanding Selective Oxidations

Functionalizing organic molecules is an important value-creating step throughout the entire chemical value-chain. Oxyfunctionalization of value-chain. Oxyfunctionalization of e.g. C–H or C=C bonds is one of the most important functionalization technologies used industrially. The major challenge in this field is the prevention of side reactions and/or the consecutive over-oxidation of the desired products. Despite its importance, a fundamental understanding of the intrinsic chemistry, and the subsequent design of a tailored engineering environment, is often missing. Industrial oxidation processes are indeed to a large extent based on empirical know-how. In this mini-review, we summarize some of our previous work to help to bridge this knowledge gap and elaborate on our ongoing research

In-hospital Delay Increases the Risk of Perforation in Adults with Appendicitis

Background: The influence of in-hospital delay (time between admission and operation) on outcome after appendectomy is controversial. Methods: A total of 1,827 adult patients underwent open or laparoscopic appendectomy for suspected appendicitis in eleven Swiss hospitals between 2003 and 2006. Of these, 1,675 patients with confirmed appendicitis were included in the study. Groups were defined according in-hospital delay (≤12 vs. >12h). Results: Delay>12h was associated with a significantly higher frequency of perforated appendicitis (29.7 vs. 22.7%; P=0.010) whereas a delay of 6 or 9h was not. Size of institution, time of admission, and surgical technique (laparoscopic vs. open) were independent factors influencing in-hospital delay. Admission during regular hours was associated with higher age, higher frequency of co-morbidity, and higher perforation rate compared to admission after hours. The logistic regression identified four independent factors associated with an increased perforation rate: age (≤65years vs. >65years, odds ratio (OR) 4.5, P0 vs. Charlson index=0, OR 2.3, P12 vs. ≤12h, OR 1.5, P=0.005). Perforation was associated with an increased reintervention rate (13.4 vs. 1.6%; P<0.001) and longer length of hospital stay (9.5 vs. 4.4days; P<0.001). Conclusions: In-hospital delay negatively influences outcome after appendectomy. In-hospital delay of more than 12h, age over 65years, time of admission during regular hours, and the presence of co-morbidity are all independent risk factors for perforation. Perforation was associated with a higher reintervention rate and increased length of hospital sta

Tracing attacks and restoring integrity with LASCAR

We present a novel method to trace the propagation of intrusions or malicious code in networked systems. Our solution is aimed at large numbers of loosely managed workstations typical of a research environment as found in CERN. The system tags events which have a potential to become harmful. On a given machine all processes that results from the tagged event are marked with the same tag and the tag is carried on to others machines if a tagged process establishes a connection. Tag creation logs are stored in a central database. When an intrusion is detected at a later time, all machines and processes that may have lost their integrity due to this incident can easily be found. This leads to a quick and effective restoration of the system. Our implementation of the system is designed to incur very little overhead on the machines and integrates easily with many flavors of the Linux operating system on any type of hardware

Isotopic Composition of Solar Wind Calcium: First in Situ Measurement by CELIAS/MTOF on Board SOHO

We present first results on the Ca isotopic abundances derived from the high resolution Mass Time-of-Flight (MTOF) spectrometer of the charge, element, and isotope analysis system (CELIAS) experiment on board the Solar and Heliospheric Observatory (SOHO). We obtain isotopic ratios 40Ca/42Ca = (128+-47) and 40Ca/44Ca = (50+-8), consistent with terrestrial values. This is the first in situ determination of the solar wind calcium isotopic composition and is important for studies of stellar modeling and solar system formation since the present-day solar Ca isotopic abundances are unchanged from their original isotopic composition in the solar nebula.Comment: 14 pages, 3 figure

Diurnal to interannual variability of low‐level cloud cover over western equatorial Africa in May–October

This study examines the diurnal to interannual variations of the stratiform cloud cover in May–October (1971–2019) from a 3-hourly station database and from ERA5 reanalyses over western equatorial Africa (WEA). The main diurnal variations of the local-scale fraction and genus of stratiform clouds are synthesized into three canonical diurnal types (i.e., “clear,” “clear afternoon,” “cloudy” days). The interannual variations of frequencies of the three diurnal types during the cloudiest months (JJAS) are mostly associated with two main mechanisms: a meridional shallow overturning cell associating more “cloudy” and less “clear” and “clear afternoon” days to anomalous southerlies below 900 hPa over and around WEA, anomalous ascent around 5°–7°N, anomalous northerlies between 875 and 700 hPa, and anomalous subsidence over the equatorial Atlantic. This circulation is strongly related to interannual variations of the equatorial Atlantic upwelling (i.e., more clouds when the upwelling is strong) associated with a meridional shift of the Intertropical Convergence Zone over the Tropical Atlantic and adjacent continents. The second mechanism operates mostly in the zonal direction and involves again the coupled ocean–atmosphere system over the equatorial Atlantic, but also the remote El Niño–Southern Oscillation (ENSO). An anomalously cold equatorial Atlantic drives increased low-level westerlies toward the Congo Basin. Warm ENSO events promote broad warm and easterly anomalies in the middle and upper troposphere, which increase the local static stability, and thus the local stratiform cloud cover over WEA. The present study suggests new mechanisms responsible for interannual variations of stratiform clouds in WEA, thus providing avenues of future research regarding the stability of the stratiform cloud deck under the ongoing differential warming of tropical ocean and land masses

Exploring hail and lightning diagnostics over the Alpine-Adriatic region in a km-scale climate model

The north and south of the Alps, as well as the eastern shores of the Adriatic Sea, are hot spots of severe convective storms, including hail and lightning associated with deep convection. With advancements in computing power, it has become feasible to simulate deep convection explicitly in climate models by decreasing the horizontal grid spacing to less than 4 km. These kilometer-scale models improve the representation of orography and reduce uncertainties associated with the use of deep convection parameterizations. In this study, we perform km-scale simulations for eight observed cases of severe convective storms (seven with and one without observed hail) over the Alpine-Adriatic region. The simulations are performed with the climate version of the regional model Consortium for Small-scale Modeling (COSMO) that runs on graphics processing units (GPUs) at a horizontal grid spacing of 2.2 km. To analyze hail and lightning we have explored the hail growth model (HAILCAST) and lightning potential index (LPI) diagnostics integrated with the COSMO-crCLIM model. Comparison with available high-resolution observations reveals good performance of the model in simulating total precipitation, hail, and lightning. By performing a detailed analysis of three of the case studies, we identified the importance of significant meteorological factors for heavy thunderstorms that were reproduced by the model. Among these are the moist unstable boundary layer and dry mid-level air, the topographic barrier, as well as an approaching upper-level trough and cold front. Although COSMO HAILCAST tends to underestimate the hail size on the ground, the results indicate that both HAILCAST and LPI are promising candidates for future climate research.</p

Vascular effects of apelin in vivo in man

ObjectivesThis study was designed to establish the direct vascular effects of apelin in vivo in man.BackgroundApelin is the endogenous ligand for the previously orphaned G-protein–coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of cardiovascular homeostasis. In pre-clinical models, apelin causes venous and arterial vasodilation.MethodsVascular effects of apelin were assessed in 24 healthy volunteers. Dorsal hand vein diameter was measured by the Aellig technique during local intravenous infusions (0.1 to 3 nmol/min) of apelin-36, (Pyr1)apelin-13, and sodium nitroprusside (0.6 nmol/min). Forearm blood flow was measured by venous occlusion plethysmography during intrabrachial infusions of apelin-36 and (Pyr1)apelin-13 (0.1 to 30 nmol/min) and subsequently in the presence or absence of a “nitric oxide clamp” (nitric oxide synthase inhibitor, L-NG-monomethylarginine [8 μmol/min], coinfused with nitric oxide donor, sodium nitroprusside [90 to 900 ng/min]), or a single oral dose of aspirin (600 mg) or matched placebo.ResultsAlthough sodium nitroprusside caused venodilation (p < 0.0001), apelin-36 and (Pyr1)apelin-13 had no effect on dorsal hand vein diameter (p = 0.2). Both apelin isoforms caused reproducible vasodilation in forearm resistance vessels (p < 0.0001). (Pyr1)apelin-13–mediated vasodilation was attenuated by the nitric oxide clamp (p = 0.004) but unaffected by aspirin (p = 0.7).ConclusionsAlthough having no apparent effect on venous tone, apelin causes nitric oxide–dependent arterial vasodilation in vivo in man. The apelin-APJ system merits further clinical investigation to determine its role in cardiovascular homeostasis

A new form of Saturn's magnetopause using a dynamic pressure balance model, based on in situ, multi‐instrument Cassini measurements

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95429/1/jgra19967.pd