325 research outputs found

    RENEB Inter-Laboratory Comparison 2021: Inter-Assay Comparison of Eight Dosimetry Assays

    No full text
    10.1667/RADE-22-00207.1Radiation Research1996535-55

    Corrigendum: “Measurement of ⁷³Ge(n,γ) cross sections and implications for stellar nucleosynthesis” [Phys. Lett. B 790 (2019) 458–465]

    Get PDF

    RENEB Inter-Laboratory Comparison 2021: The Gene Expression Assay

    No full text
    Early and high-throughput individual dose estimates are essential following large-scale radiation exposure events. In the context of the Running the European Network for Biodosimetry and Physical Dosimetry (RENEB) 2021 exercise, gene expression assays were conducted and their corresponding performance for dose-assessment is presented in this publication. Three blinded, coded whole blood samples from healthy donors were exposed to 0, 1.2 and 3.5 Gy X-ray doses (240 kVp, 1 Gy/min) using the X-ray source Yxlon. These exposures correspond to clinically relevant groups of unexposed, low dose (no severe acute health effects expected) and high dose exposed individuals (requiring early intensive medical health care). Samples were sent to eight teams for dose estimation and identification of clinically relevant groups. For quantitative reverse transcription polymerase chain reaction (qRT-PCR) and microarray analyses, samples were lysed, stored at 20°C and shipped on wet ice. RNA isolations and assays were run in each laboratory according to locally established protocols. The time-to-result for both rough early and more precise later reports has been documented where possible. Accuracy of dose estimates was calculated as the difference between estimated and reference doses for all doses (summed absolute difference, SAD) and by determining the number of correctly reported dose estimates that were defined as ±0.5 Gy for reference doses 3 Gy, as recommended for triage dosimetry. We also examined the allocation of dose estimates to clinically/diagnostically relevant exposure groups. Altogether, 105 dose estimates were reported by the eight teams, and the earliest report times on dose categories and estimates were 5 h and 9 h, respectively. The coefficient of variation for 85% of all 436 qRT-PCR measurements did not exceed 10%. One team reported dose estimates that systematically deviated several-fold from reported dose estimates, and these outliers were excluded from further analysis. Teams employing a combination of several genes generated about two-times lower median SADs (0.8 Gy) compared to dose estimates based on single genes only (1.7 Gy). When considering the uncertainty intervals for triage dosimetry, dose estimates of all teams together were correctly reported in 100% of the 0 Gy, 50% of the 1.2 Gy and 50% of the 3.5 Gy exposed samples. The order of dose estimates (from lowest to highest) corresponding to three dose categories (unexposed, low dose and highest exposure) were correctly reported by all teams and all chosen genes or gene combinations. Furthermore, if teams reported no exposure or an exposure >3.5 Gy, it was always correctly allocated to the unexposed and the highly exposed group, while low exposed (1.2 Gy) samples sometimes could not be discriminated from highly (3.5 Gy) exposed samples. All teams used FDXR and 78.1% of correct dose estimates used FDXR as one of the predictors. Still, the accuracy of reported dose estimates based on FDXR differed considerably among teams with one team's SAD (0.5 Gy) being comparable to the dose accuracy employing a combination of genes. Using the workflow of this reference team, we performed additional experiments after the exercise on residual RNA and cDNA sent by six teams to the reference team. All samples were processed similarly with the intention to improve the accuracy of dose estimates when employing the same workflow. Re-evaluated dose estimates improved for half of the samples and worsened for the others. In conclusion, this inter-laboratory comparison exercise enabled (1) identification of technical problems and corrections in preparations for future events, (2) confirmed the early and high-throughput capabilities of gene expression, (3) emphasized different biodosimetry approaches using either only FDXR or a gene combination, (4) indicated some improvements in dose estimation with FDXR when employing a similar methodology, which requires further research for the final conclusion and (5) underlined the applicability of gene expression for identification of unexposed and highly exposed samples, supporting medical management in radiological or nuclear scenario

    El Magneite

    No full text
    Este proyecto tiene como objetivo conseguir un fluido magneto-reológico que pueda tener aplicaciones como freno a través de un cambio en su coeficiente de rozamiento generado por una orientación en sus partículas mediante el uso de un imán. Para su elaboración hemos utilizado polvo de hierro y diferentesfluidos mezclados para formar una sustancia líquida con propiedades magnéticas en la que el polvo de hierro se encuentra en suspensión. Como ensayo hemos utilizado una rampa de frenado y con los resultados obtenidos hemos llegado a la conclusión de que con el uso de imanes más potentes se podrían alcanzar lascaracterísticas esperadas y necesarias para su uso como freno

    Neutron-induced fission cross sections of <math><mmultiscripts><mi>Th</mi><mprescripts/><none/><mn>232</mn></mmultiscripts></math> and <math><mmultiscripts><mi mathvariant="normal">U</mi><mprescripts/><none/><mn>233</mn></mmultiscripts></math> up to 1 GeV using parallel plate avalanche counters at the CERN n_TOF facility

    No full text
    International audienceThe neutron-induced fission cross sections of Th232 and U233 were measured relative to U235 in a wide neutron energy range up to 1 GeV (and from fission threshold in the case of Th232, and from 0.7 eV in case of U233), using the white-spectrum neutron source at the CERN Neutron Time-of-Flight (n_TOF) facility. Parallel plate avalanche counters (PPACs) were used, installed at the Experimental Area 1 (EAR1), which is located at 185 m from the neutron spallation target. The anisotropic emission of fission fragments were taken into account in the detection efficiency by using, in the case of U233, previous results available in EXFOR, whereas in the case of Th232 these data were obtained from our measurement, using PPACs and targets tilted 45∘ with respect to the neutron beam direction. Finally, the obtained results are compared with past measurements and major evaluated nuclear data libraries. Calculations using the high-energy reaction models INCL++ and ABLA07 were performed and some of their parameters were modified to reproduce the experimental results. At high energies, where no other neutron data exist, our results are compared with experimental data on proton-induced fission. Moreover, the dependence of the fission cross section at 1 GeV with the fissility parameter of the target nucleus is studied by combining those (p,f) data with our (n,f) data on Th232 and U233 and on other isotopes studied earlier at n_TOF using the same experimental setup

    Neutron-induced fission cross sections of Th 232 and U 233 up to 1 GeV using parallel plate avalanche counters at the CERN n_TOF facility

    Get PDF
    The neutron-induced fission cross sections of 232^{232}Th and 233^{233}U were measured relative to 235^{235}U in a wide neutron energy range up to 1 GeV (and from fission threshold in the case of 232^{232}Th, and from 0.7 eV in case of 233^{233}U), using the white-spectrum neutron source at the CERN Neutron Time-of-Flight (n_TOF) facility. Parallel plate avalanche counters (PPACs) were used, installed at the Experimental Area 1 (EAR1), which is located at 185 m from the neutron spallation target. The anisotropic emission of fission fragments were taken into account in the detection efficiency by using, in the case of 233^{233}U, previous results available in EXFOR, whereas in the case of 232^{232}Th these data were obtained from our measurement, using PPACs and targets tilted 45∘ with respect to the neutron beam direction. Finally, the obtained results are compared with past measurements and major evaluated nuclear data libraries. Calculations using the high-energy reaction models INCL++ and ABLA07 were performed and some of their parameters were modified to reproduce the experimental results. At high energies, where no other neutron data exist, our results are compared with experimental data on proton-induced fission. Moreover, the dependence of the fission cross section at 1 GeV with the fissility parameter of the target nucleus is studied by combining those (p,f) data with our (n,f) data on 232^{232}Th and 233^{233}U and on other isotopes studied earlier at n_TOF using the same experimental setup

    Zr 92 (n,g) and (n,tot) measurements at the GELINA and n_TOF facilities

    No full text

    74^{74}Ge(n,γn,\gamma ) cross section below 70 keV measured at n_TOF CERN

    Get PDF
    Neutron capture reaction cross sections on 74^{74}Ge are of importance to determine 74^{74}Ge production during the astrophysical slow neutron capture process. We present new resonance data on 74^{74}Ge(n,γn,\gamma ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment

    74 Ge(n, γ) cross section below 70 keV measured at n_TOF CERN

    No full text
    Neutron capture reaction cross sections on 74Ge are of importance to determine 74Ge production during the astrophysical slow neutron capture process. We present new resonance data on 74Ge(n, γ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment.Austrian Science Fund J3503UK Science and Facilities Council ST/M006085/1European Research Council 677497Charles University UNCE/SCI/01

    74^{74}Ge(n,γn,\gamma ) cross section below 70 keV measured at n_TOF CERN

    No full text
    International audienceAbstract Neutron capture reaction cross sections on 74^{74} 74 Ge are of importance to determine 74^{74} 74 Ge production during the astrophysical slow neutron capture process. We present new resonance data on 74^{74} 74 Ge( n,γn,\gamma n , γ ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment
    • …
    corecore