24 research outputs found

    Chicoric acid is an anti-oxidant molecule stimulating AMP Kinase, PGC-1alpha expression and mitochondrial activity in a model of skeletal muscular cells

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    Chicoric acid is an anti-oxidant molecule stimulating AMP Kinase, PGC-1alpha expression and mitochondrial activity in a model of skeletal muscular cells. 8. Congrès de Physiologie, de Pharmacologie et de Thérapeutiqu

    Chicoric acid is an anti-oxidant molecule stimulating AMP Kinase, PGC-1alpha expression and mitochondrial activity in a model of skeletal muscular cells

    No full text
    Chicoric acid is an anti-oxidant molecule stimulating AMP Kinase, PGC-1alpha expression and mitochondrial activity in a model of skeletal muscular cells. 8. Congrès de Physiologie, de Pharmacologie et de Thérapeutiqu

    Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis

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    Thyroid hormone is a major determinant of energy expenditure and a key regulator of mitochondrial activity. We have previously identified a mitochondrial triiodothyronine receptor (p43) that acts as a mitochondrial transcription factor of the organelle genome, which leads, in vitro and in vivo, to a stimulation of mitochondrial biogenesis. Here we generated mice specifically lacking p43 to address its physiological influence. We found that p43 is required for normal glucose homeostasis. The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancreatic islets and a loss of glucose-stimulated insulin secretion. Moreover, a high-fat/high-sucrose diet elicited more severe glucose intolerance than that recorded in normal animals. In addition, we observed in p43(-/-) mice both a decrease in pancreatic islet density and in the activity of complexes of the respiratory chain in isolated pancreatic islets. These dysfunctions were associated with a down-regulation of the expression of the glucose transporter Glut2 and of Kir6.2, a key component of the K(ATP) channel. Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic beta-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor

    Barriers to participation in mental health research: are there specific gender, ethnicity and age related barriers?

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    <p>Abstract</p> <p>Background</p> <p>It is well established that the incidence, prevalence and presentation of mental disorders differ by gender, ethnicity and age, and there is evidence that there is also differential representation in mental health research by these characteristics. The aim of this paper is to a) review the current literature on the nature of barriers to participation in mental health research, with particular reference to gender, age and ethnicity; b) review the evidence on the effectiveness of strategies used to overcome these barriers.</p> <p>Method</p> <p>Studies published up to December 2008 were identified using MEDLINE, PsycINFO and EMBASE using relevant mesh headings and keywords.</p> <p>Results</p> <p>Forty-nine papers were identified. There was evidence of a wide range of barriers including transportation difficulties, distrust and suspicion of researchers, and the stigma attached to mental illness. Strategies to overcome these barriers included the use of bilingual staff, assistance with travel, avoiding the use of stigmatising language in marketing material and a focus on education about the disorder under investigation. There were very few evaluations of such strategies, but there was evidence that ethnically matching recruiters to potential participants did not improve recruitment rates. Educational strategies were helpful and increased recruitment.</p> <p>Conclusion</p> <p>Mental health researchers should consider including caregivers in recruitment procedures where possible, provide clear descriptions of study aims and describe the representativeness of their sample when reporting study results. Studies that systematically investigate strategies to overcome barriers to recruitment are needed.</p

    Conjunctiva

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    Tuberculomas intracranianos: estudo clĂ­nico e patolĂłgico

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    Vinte e quatro tuberculomas intracranianos foram encontrados em 17 pacientes numa análise retrospectiva de 19.760 autópsias e 72.972 biópsias consecutivas, num período de 41 anos e 4 meses. Os 17 pacientes representaram 4,2% dos casos das lesões expansivas intracranianas. A maioria dos tuberculomas se localizava nos hemisférios cerebrais, e um terço deles, no cerebelo. Cerca de 65% dos pacientes tinham idade inferior a 20 anos. O quadro clínico é semelhante ao das outras lesões expansivas intracranianas estando relacionado à hipertensão intracraniana e à localização da lesão. Os dados encontrados são comparados aos das várias séries publicadas em diferentes países

    Compressive and Infiltrative Optic Neuropathies

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