An elastoplastic framework for granular materials becoming cohesive through mechanical densification. Part I - small strain formulation

Mechanical densification of granular bodies is a process in which a loose material becomes increasingly cohesive as the applied pressure increases. A constitutive description of this process faces the formidable problem that granular and dense materials have completely different mechanical behaviours (nonlinear elastic properties, yield limit, plastic flow and hardening laws), which must both be, in a sense, included in the formulation. A treatment of this problem is provided here, so that a new phenomenological, elastoplastic constitutive model is formulated, calibrated by experimental data, implemented and tested, that is capable of describing the transition between granular and fully dense states of a given material. The formulation involves a novel use of elastoplastic coupling to describe the dependence of cohesion and elastic properties on the plastic strain. The treatment falls within small strain theory, which is thought to be appropriate in several situations; however, a generalization of the model to large strain is provided in Part II of this paper.Comment: 42 pages, 27 figure

Positive psychology in the investigation of psychedelics and entactogens: A critical review

RATIONALE: We reviewed the concepts and empirical findings in studies with psychedelics and entactogens related to positive psychology - the study of healthy human functioning, well-being and eudaemonia. It is an unresolved question how beneficial effects of psychedelics and entactogens are related to the potential risks of these substances - particularly in non-clinical settings. METHODS: We searched in PubMed, PsychINFO and the Cochrane Library for controlled clinical and epidemiological studies which applied concepts from positive psychology. We included N = 77 eligible studies with 9876 participants published before November 1st, 2017: (1) quantitative studies (N = 54), (2) preliminary or exploratory studies and reviews not including meta-analyses (N = 17), and (3) studies evidencing primarily negative results (N = 6). RESULTS: Positive psychology concepts have been applied for measuring effects of clinical trials, recreational and ceremonial use of psychedelics and entactogens. Psychedelics and entactogens were shown to produce acute and long-term effects on mood, well-being, prosocial behaviours, empathy, cognitive flexibility, creativity, personality factors like openness, value orientations, nature-relatedness, spirituality, self-transcendence and mindfulness-related capabilities. CONCLUSIONS: There is preliminary evidence for beneficial effects of psychedelics and entactogens on measures of positive psychology in clinical and healthy populations, however their sustainability remains largely unresolved. The reported results must be considered preliminary due to methodological restrictions. Since longitudinal data on both positive and adverse effects of psychedelics are lacking, more rigorous and standardized measures from positive psychology should be applied in less biased populations with prospective longitudinal designs to carefully assess the benefit-risk-ratio. This article is part of the Special Issue entitled 'Psychedelics: New Doors, Altered Perceptions'