Additional file 1: Table S1. of The St. George’s Respiratory Questionnaire as a prognostic factor in IPF

Spearman’s correlation coefficients between SGRQ and baseline physiological measures. Table S2. The relationship between SGRQ and comorbidities. Table S3. SGRQ domain as predictors for mortality. (DOCX 29 kb

Diagnostic criteria for lung-dominant connective tissue disease.

<p>Criteria derived from Reference 11.</p><p>ANA: antinuclear antibody; RF: rheumatoid factor; CCP: cyclic citrullinated peptide; Scl-70: Sclero 70; ds DNA: double-stranded DNA; RNP: ribonucleoprotein.</p><p>Diagnostic criteria for lung-dominant connective tissue disease.</p

Histogram of MPAP.

<p>Histogram of MPAP.</p

Baseline characteristics and physiology of patients with and without PH.

<p>Data are presented as means ± SD or numbers.</p><p>N = 100 except for FVC (n = 99), DLCO (n = 96), MMRC (n = 95), 6MWD (n = 91), Lowest SpO2 (n = 91).</p><p>Baseline characteristics and physiology of patients with and without PH.</p

Kaplan-Meier curves for survival according to MPAP (p = 0.005).

<p>Survival curves were compared with log-rank statistics.</p

Autoantibody profile of the study cohort.

<p>Data are presented as number. Some patients had multiple positive serological tests.</p><p>Autoantibody profile of the study cohort.</p

Results of stepwise multivariate Cox proportional hazard model.

<p>Used for variables that were significant in univariate analysis (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108339#pone-0108339-t004" target="_blank">Table 4</a>).</p><p>FVC, DLCO, PaO₂, 6MWD, Lowest SpO₂, MPAP.</p><p>Results of stepwise multivariate Cox proportional hazard model.</p

Results of the univariate Cox proportional hazard model.

<p>HR: hazard ratio; CI: confidence interval.</p><p>Results of the univariate Cox proportional hazard model.</p

Baseline characteristics.

<p>Data are presented as means ± SD or numbers.</p><p>BMI: body mass index; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; MMRC: Modified Medical Research Council Dyspnea Scale; 6MWD: 6 minute walk distance; MPAP: mean pulmonary artery pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance.</p><p>N = 100 except for FVC (n = 99), DLCO (n = 96), MMRC (n = 95), 6MWD (n = 91), Lowest SpO2 (n = 91).</p><p>Baseline characteristics.</p

Screening and inclusion process for patients in the study.

<p>Screening and inclusion process for patients in the study.</p