Eosinofilik gastointestinal hastalıklar: Eosinofilik gastro intestinal hastalıkların görülme yaşı küçülüyor mu?

Eozinofilik gastrointestinal hastalıklar gastrointestinal kanalın eozinofilik infiltrasyonu ile karakterizedir. Hastalığın belirtileri etkilenen sindirim segmentine ve sindirim kanalının farklı tabakalarının tutulumuna bağlı olarak değişiklik g&ouml;sterir. Eozinofilik gastrointestinal hastalıklar, eozinofilik &ouml;zofajit, eozinofilik gastroenterit ve eozinofilik kolit gibi alt gruplara ayrılır. Eozinofilinin yerleşimine bağlı olarak mukozal, serozal ya da m&uuml;sk&uuml;ler hastalık olarak gruplamak m&uuml;mk&uuml;nd&uuml;r. Mukozal hastalıklar bunların arasında en yaygın olanıdır. Eozinofilik &ouml;zofajitli hastalar hazımsızlık, kusma, disfaji şikayetleri g&ouml;sterirken, eozinofilik gastroenterit hastaları karın ağrısı, ishal ve kanlı dışkılama şikayetlerine sahiptir. Eozinofilik kolitli hastalarda ise tipik olarak ishal ve alt kadran ağrısı şikayetlerine rastlanır. Hastalık tipik olarak 3. ve 5. dekatlarda g&ouml;r&uuml;lmekle birlikte diğer yaş gruplarında da g&ouml;r&uuml;lebilir. Ana tedavi se&ccedil;enekleri arasında steroid ve diyet değişikliği vardır. 2011 ile 2012 yılları arasında &ccedil;ocuk gastroenteroloji b&ouml;l&uuml;m&uuml;m&uuml;zde 4 hastaya eozinofilik gastrointestinal hastalık tanısı konuldu. Bunlardan 2 tanesi eozinofilik &ouml;zofajit, 1 tanesi eozinofilik kolit, diğeri ise eozinofilik proktokolit tanısı aldı. Bu makalede eozinofilik gastrointestinal hastalık tanısı almış &ccedil;ocuk hastalarımız g&uuml;ncel &ccedil;alışmalar ışığında g&ouml;zden ge&ccedil;irildi. Eosinophilic gastrointestinal disorders constitute a pathology characterized by eosinophilic infiltration of the gastrointestinal tract, the symptoms of which vary depending on the affected digestive segments and the involvement of the different layers of the digestive wall. Eosinophilic gastrointestinal diseases include subcategories such as eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis, and depending on the localization of the eosinophilia, it is possible to group them as mucosal, serosal or muscular disease. Mucosal involvement is the most common. Patients with eosinophilic esophagitis suffer from nutrition intolerance, vomiting, and dysphagia; for patients with eosinophilic gastroenteritis, complaints are abdominal pain, diarrhea and blood in stool; and for patients with eosinophilic colitis, they are typically diarrhea and lower quadrant pain. The disease is typically observed in but not limited to the 3rd to 5th decades. The main therapeutic options include steroids and dietary modification. Between 2011 and 2012, 4 patients were diagnosed in our pediatric gastroenterology department. Two were diagnosed with eosinophilic esophagitis, one with eosinophilic colitis and one with eosinophilic proctocolitis. This study aimed to review eosinophilic gastrointestinal diseases in light of the recent studies, referring to children diagnosed with eosinophilic gastrointestinal diseas</p

Obstructive chronic pancreatitis with transient eosinophilia in a 13-year-oldchild

&Ccedil;ocuklarda pankreatik kanalın, doğumsal veya edinsel darlığının bir sonucu olarak obstr&uuml;ktif kronik pankreatit ortaya &ccedil;ıkar. Belirgin histolojik değişiklikler periduktal fibrozis ve geri kalan duktal alanda genişlemelerle karakterizedir. Tanıda genellikle endoskopik retrograd kolanjiopankreatikografi, ultrasonografi ve pankreatik fonksiyon testleri gibi y&ouml;ntemler kullanılmaktadır. Eozinofili sıklıkla alerjik rinit, astım, parazitik enfeksiyonlar ve ila&ccedil; reaksiyonu ile ilişkilidir. Seyrek olarak da kronik obstr&uuml;ktif pankreatik hastalıklarda tarif edilmiştir. Bu makalede; karın ağrısı ile başvuran kronik obstr&uuml;ktif pankreatitli bir olguyu sunuyoruz. Olgumuzda, pankreatit semptomları ve eozinofili pankreasa stent yerleştirilmesi ile d&uuml;zelmiştir. Anahtar kelimeler: &nbsp; &nbsp; Kronik pankreatit, eozinofili, &ccedil;ocuk Obstructive chronic pancreatitis in children occurs as a result of congenital or acquired stricture of the pancreatic duct. The prominent histologic changes are characterized by periductal fibrosis and subsequent ductal dilatation. Diagnosis is usually made by imaging studies such as endoscopic retrograde cholangiopancreaticography, ultrasonography, and pancreatic function testing. Eosinophilia is frequently associated with allergic rhinitis, asthma, parasitic infections, and drug reactions. It has been infrequently described with chronic obstructive pancreatic diseases. In this article, we present a patient with eosinophilia and abdominal pain with chronic obstructive pancreatitis. In our case, the symptoms of pancreatitis and eosinophilia improved with pancreatic stent placement. Keywords: &nbsp; &nbsp; Chronic pancreatitis, eosinophilia, child &nbsp; &nbsp;</p

A rare cause of acute mesenteric ischemia: JAK2 positivity and chronic active hepatitis

Short bowel syndrome occurs as a result of insufficiency in the total length of the small intestine to provide adequate supply of nutrients. Seventy-five percent of cases are due to massive intestinal resection. A 35-year-old male complaining of abdominal pain was admitted to the gastroenterology department. A CT scan was performed, showing total occlusion of the portal vein and superior mesenteric vein. During the operation, widespread edema and necrosis of the small intestine were found. The necrotic segments of the small intestine were resected. The spleen was larger than normal and, in some parts, infarcts were evident, thus asplenectomy was also performed during surgery. A second-look procedure was performed 24 hours later, and an additional 10 cm jejunal resection and anastomosis was performed. His further evaluations revealed myeloproliferative disease and chronic active hepatitis B leading to thrombosis. Essential thrombocytosis and portal vein thrombosis are common in hepatitis B infection. Patients with complaints of abdominal pain in the context of essential thrombocytosis and hepatitis B should be handled with caution as they are at risk of developing portal vein thrombosis

The possible relationship between Campylobacter spp./Arcobacter spp. and patients with ulcerative colitis

Background and aimsThe role of bacterial infection in the pathogenesis of ulcerative colitis (UC) is under investigation. This study aims to (i) determine the prevalence of Campylobacter spp. and Arcobacter spp. in patients with UC, (ii) identify the antibiotic susceptibility of isolated agents, and (iii) investigate the role of these microorganisms in the pathogenesis and/or activation of UC.Patients and methodsEighty patients with UC and 40 healthy individuals were included in the study. Stool samples were used for cultural examination. Direct plating, membrane filtration, and enrichment methods were used for isolation. 16s rRNA sequence analysis was used for definitive identification of isolates that were identified phenotypically.ResultsIn the UC group, 20 (25%) patients had proctitis, 40 (50%) patients had left-type involvement, and 20 (25%) patients had extensive involvement. Campylobacter spp. were isolated from four (5%) patients in the UC group and isolates were identified as C. curvus, C. concisus, C. sputorum, and C. jejuni. C. concisus and C. jejuni were found to be resistant to ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole. C. jejuni was also resistant to tetracycline. All samples were negative for Arcobacter spp. The samples from the control group neither showed the presence of Campylobacter spp. nor Arcobacter spp.ConclusionGiven the clinical, endoscopic, and bacteriological examination results, it is believed that Campylobacter spp. are agents that cause flare-up clinically by being superimposed on the primary disease, rather than agents that initiate the disease in patients with UC. Arcobacter spp., which are known to cause acute gastroenteritis, were not found to be associated with UC

Determinig of Autoregressive Parameters from Electrogastrogram Signals Using Cramer-Rao Lower Bound

Gastroparesis is a kind of stomach disease that is identified with delay of gastric emptying of solid food without mechanical obstruction. The disease is diagnosed by invasive techniques. Scintigraphy imaging technique is accepted as the gold standard in diagnosis although having many disadvantages. In this study. non invasive EGG signals were obtained from gastroparesis patients and healthy volunteers. Power Spectral Density (PSD) graphs were obtained for purpose of determining feature in frequency axis for diagnosis. PSD method for which parametric method that is used to the signals, was determined using Cramer-Rao Lower Bound (CRLB) method