Rapid Total Synthesis of (±)Trigonoliimine A via a Strecker/Houben–Hoesch Sequence

A novel synthetic route to the hexacyclic system of trigonoliimine A was accomplished in four steps from <i>N</i>-phthaloyl 6-OMe-tryptamine. Key reactions include a three-component Strecker-type reaction to fashion the two C–N bonds in the D ring and a subsequent Houben–Hoesch type cyclization to deliver the characteristic seven-membered C ring

Table_1_Case report: Recurrent pontine stroke and leukoencephalopathy in a patient with de novo mutation in COL4A1.DOCX

This report presents a case of pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL) in a 35 year-old male patient. The patient exhibited a consistent history of recurrent ischemic strokes, concentrated primarily in the pons region, accompanied by concurrent manifestations of leukoencephalopathy and microbleeds. Genetic evaluation revealed a heterozygous missense mutation consistent with c.3431C>G, p. Thr1144Arg substitution within exon 40 of the COL4A1 gene. This mutation was also identified in the patient’s mother, affirming an autosomal dominant inheritance model. Our findings serve as testament to the potential role of mutation in the exon 40 of COL4A1 in the pathogenesis and progression of PADMAL, contributing to ongoing efforts aimed at better understanding the genetic basis of this debilitating disorder.</p

sj-pdf-4-wso-10.1177_17474930221140792 – Supplemental material for Human blood metabolites and lacunar stroke: A Mendelian randomization study

Supplemental material, sj-pdf-4-wso-10.1177_17474930221140792 for Human blood metabolites and lacunar stroke: A Mendelian randomization study by Meng-Nan Guo, Xiao-Yan Hao, Jie Tian, Yun-Chao Wang, Jia-Di Li, Yu Fan, Jing-Jing Shi, Dong-Rui Ma, Shuang-Jie Li, Chun-Yan Zuo, Yuan-Yuan Liang, Meng-Jie Li, Si Shen, Fen Liu, Da-Bao Yao, Yu-Ming Xu and Chang-He Shi in International Journal of Stroke</p

sj-pdf-3-wso-10.1177_17474930221140792 – Supplemental material for Human blood metabolites and lacunar stroke: A Mendelian randomization study

Supplemental material, sj-pdf-3-wso-10.1177_17474930221140792 for Human blood metabolites and lacunar stroke: A Mendelian randomization study by Meng-Nan Guo, Xiao-Yan Hao, Jie Tian, Yun-Chao Wang, Jia-Di Li, Yu Fan, Jing-Jing Shi, Dong-Rui Ma, Shuang-Jie Li, Chun-Yan Zuo, Yuan-Yuan Liang, Meng-Jie Li, Si Shen, Fen Liu, Da-Bao Yao, Yu-Ming Xu and Chang-He Shi in International Journal of Stroke</p

sj-pdf-5-wso-10.1177_17474930221140792 – Supplemental material for Human blood metabolites and lacunar stroke: A Mendelian randomization study

Supplemental material, sj-pdf-5-wso-10.1177_17474930221140792 for Human blood metabolites and lacunar stroke: A Mendelian randomization study by Meng-Nan Guo, Xiao-Yan Hao, Jie Tian, Yun-Chao Wang, Jia-Di Li, Yu Fan, Jing-Jing Shi, Dong-Rui Ma, Shuang-Jie Li, Chun-Yan Zuo, Yuan-Yuan Liang, Meng-Jie Li, Si Shen, Fen Liu, Da-Bao Yao, Yu-Ming Xu and Chang-He Shi in International Journal of Stroke</p

sj-pdf-1-wso-10.1177_17474930221140792 – Supplemental material for Human blood metabolites and lacunar stroke: A Mendelian randomization study

Supplemental material, sj-pdf-1-wso-10.1177_17474930221140792 for Human blood metabolites and lacunar stroke: A Mendelian randomization study by Meng-Nan Guo, Xiao-Yan Hao, Jie Tian, Yun-Chao Wang, Jia-Di Li, Yu Fan, Jing-Jing Shi, Dong-Rui Ma, Shuang-Jie Li, Chun-Yan Zuo, Yuan-Yuan Liang, Meng-Jie Li, Si Shen, Fen Liu, Da-Bao Yao, Yu-Ming Xu and Chang-He Shi in International Journal of Stroke</p

sj-pdf-2-wso-10.1177_17474930221140792 – Supplemental material for Human blood metabolites and lacunar stroke: A Mendelian randomization study

Supplemental material, sj-pdf-2-wso-10.1177_17474930221140792 for Human blood metabolites and lacunar stroke: A Mendelian randomization study by Meng-Nan Guo, Xiao-Yan Hao, Jie Tian, Yun-Chao Wang, Jia-Di Li, Yu Fan, Jing-Jing Shi, Dong-Rui Ma, Shuang-Jie Li, Chun-Yan Zuo, Yuan-Yuan Liang, Meng-Jie Li, Si Shen, Fen Liu, Da-Bao Yao, Yu-Ming Xu and Chang-He Shi in International Journal of Stroke</p