Food in the City: Community-Driven Agriculture across the United States

Urban Agriculture is an accepted practice in many cities and countries, and has attracted a broad cross-section of people across the United States to start growing food in their communities. In some cases, the motivation behind Urban Agriculture is clear, but throughout the history of Urban Agriculture in the United States there have been many reasons why urbanites have started growing food. Such reasons include an ideological battle against conventional agriculture, the need for food itself, the desire to recreate, and the urge to educate others. The motivation behind the practice varies from location to location with national trends shifting throughout history as communities struggled to understand what Urban Agriculture meant to them. Ultimately, however, the motivations of the Americans on the ground practicing Urban Agriculture are largely undocumented. Through a series of interviews with practitioners of Urban Agriculture across the United States, I have gathered data suggesting that the primary reasons why Americans are growing food in cities today are to have a career in a profession they enjoy and to educate others about the benefits they see in Urban Agriculture

Identifying and modeling the contribution of nuclear receptors to environmental obesogen-induced toxicity in bone

Bone is a dynamic tissue, where bone forming osteoblasts and bone resorbing osteoclasts maintain homeostasis. Research into bone toxicology has largely focused on pharmaceutical side effects adversely affecting bone development. However, many environmental toxicants can regulate bone homeostasis. Recently, the nuclear receptor peroxisome proliferator activated receptor gamma (PPARγ) has emerged as an important target of environmental toxicants. PPARγ dimerizes with the retinoid-X receptor alpha (RXRα), is a central transcription factor in adipogenesis, and in bone can transdifferentiate osteoblasts into adipocytes by suppressing osteogenic pathways. The central hypothesis of this dissertation is that environmental chemicals can adversely affect bone homeostasis by activating nuclear receptors in bone cells – particularly osteoblasts and osteoclasts – to perturb cellular differentiation and function. Three study aims were developed to test and refine this hypothesis. First, a set of structurally diverse environmental PPARγ agonists were individually applied to mouse primary bone marrow mesenchymal stromal cell cultures undergoing osteogenic differentiation. In vitro PPARγ ligand treatment suppressed osteogenesis and stimulated adipogenesis. Organotin compounds (tributyltin, triphenyltin) in particular more efficaciously suppressed osteogenesis. The second aim characterized the effects of in vivo tributyltin exposure on bone microarchitecture in female C57Bl/6 mice. Tributyltin exposure resulted in a thinner cortical bone, but significantly increased trabecular mineralization. Further analyses suggested that tributyltin did not suppress osteoclast numbers but rather changed osteoclast function, minimally attenuating the resorptive function and enhancing their ability to generate osteogenesis-stimulating factors. Furthermore, tributyltin activated not only PPARγ, but also RXR and liver X receptors. The third aim established the utility of Generalized Concentration Addition in modeling PPARγ activation by mixtures of full and partial PPARγ agonists. A complex mixture of multiple phthalate compounds activated an in vitro PPARγ reporter assay, and the individual dose-responses of each compound were used to construct modeled responses. The comparisons of empirical data and model predictions supported the use of Generalized Concentration Addition in modeling a complex mixture of environmental PPARγ agonists. Together, these studies support and establish important toxicological mechanisms related to PPARγ and RXRα activation in different aspects of bone biology and provide a basis for studying mixture effects of PPARγ agonists

The Land of Saddle-bags: A Study of the Mountain People of Appalachia

This charming account of life in Appalachia at the turn of the century is one of the three most important books from the early twentieth century that, as Dwight Billings writes in his foreword, have “had a profound and lasting impact on how we think about Appalachia and, indeed, on the fact that we commonly believe that such a place and people can be readily identified.” Originally published in 1924, it was advertised as a “racy book, full of the thrill of mountain adventure and the delicious humor of vigorously human people.” James Watt Raine, professor of English literature and later head of the English and drama departments at Berea College from 1906 until his retirement in 1939, provides eyewitness accounts of mountain speech and folksinging, education, religion, community, politics, and farming. In a conscious effort to dispel the negative stereotype of the drunken, slothful, gun-toting hillbilly prone to violence, Raine presents positive examples from his own experiences among the region\u27s native inhabitants. A lively, first-hand account of a Berea College professor\u27s favorable experience with mountain people. -- Now & Then Will enable modern readers to experience how early-twentieth-century writers viewed the Appalachian region and its people. The foreword, penned by Dwight Billings, is especially outstanding as a modern critique of the work. -- Register of the Kentucky Historical Society First published in 1924, The Land of the Saddle-Bags provides a unique and timeless study of Appalachia and its people. -- The Bourbon Timeshttps://uknowledge.uky.edu/upk_united_states_history/1014/thumbnail.jp

Experienees of a Packer in the Washington Territory Mining Camps During the Sixties

"William S. Lewis, Historian, through interviews and conferences with James W. Watt during the past two years, has secured this illuminating and helpful narrative of forceful and dramatic experiences during the placer mining days in Washington Territory, including...

Radial versus femoral access for rotational atherectomy: A UK observational study of 8622 patients

Background—Rotational atherectomy (RA) is an important interventional tool for heavily calcified coronary lesions. We compared the early clinical outcomes in patients undergoing RA using radial or femoral access. Methods and Results—We identified all patients in England and Wales who underwent RA between January 1, 2005, and March 31, 2014. Eight thousand six hundred twenty-two RA cases (3069 radial and 5553 femoral) were included in the analysis. The study primary outcome was 30-day mortality. Propensity scores were calculated to determine the factors associated with treatment assignment to radial or femoral access. Multivariable logistic regression analysis, using the calculated propensity scores, was performed. Thirty-day mortality was 2.2% in the radial and 2.3% in the femoral group (P=0.76). Radial access was associated with equivalent 30-day mortality (adjusted odds ratio [OR], 1.06; 95% confidence interval [CI], 0.77–1.46; P=0.71), procedural success (OR, 1.04; 95% CI, 0.84–1.29; P=0.73), major adverse cardiac and cerebrovascular events (OR, 1.05; 95% CI, 0.80–1.38; P=0.72), and net adverse clinical events (OR, 0.90; 95% CI, 0.71–1.15; P=0.41), but lower rates of in-hospital major bleeding (OR, 0.62; 95% CI, 0.40–0.98; P=0.04) and major access site complications (OR, 0.05; 95% CI, 0.01–0.38; P=0.004), compared with femoral access. Conclusions—In this large real-world study of patients undergoing RA, radial access was associated with equivalent 30-day mortality and procedural success, but reduced major bleeding and access site complications, compared with femoral access