Rolling Tachyon in Brane World Cosmology from Superstring Field Theory

The pressureless tachyonic matter recently found in superstring field theory has an over-abundance problem in cosmology. We argue that this problem is naturally solved in the brane inflationary scenario if almost all of the tachyon energy is drained (via its coupling to the inflaton and matter fields) to heating the universe, while the rest of the tachyon energy goes to a network of cosmic strings (lower-dimensional BPS D-branes) produced during the tachyon rolling at the end of inflation.Comment: 4 pages, one figure. This version quantifies constraints on various phenomenological models for tachyon deca

An Attempt to Determine the Largest Scale of Primordial Density Perturbations in the Universe

Inflationary cosmology predicts that the particle horizon should be generically much bigger than the present-day Hubble radius, $1/H_0$. This implies a special regime of super-Hubble scale energy density fluctuations imprinted on the cosmic microwave background radiation (CMBR), which from present theory could only be explained by inflation Causality constraints are used to determine models for the power spectrum that accommodate a suppression scale. A three parameter likelihood analysis is performed of the COBE-DMR 4-year data with respect to the amplitude, spectral index, and suppression scale. It is found that all suppression length scales larger than $1/H_0$ are consistent with the data, but that scales of order $1/H_0$ are slightly preferred, at roughly the one-sigma level. Many non-inflation models would be consistent with a small suppression length scale, whereas for standard inflation models, the duration of the inflation epoch would have to be bounded by a fairly small upper limit. Suppression scales smaller than $1/H_0$ are strongly excluded by the anisotrophy data.Comment: 9 pages, Latex, 1 figure, additional tests reporte

Magnetic Knots as The origin of Spikes in the Gravitational Waves Backgrounds

The dynamical symmetries of hot and electrically neutral plasmas in a highly conducting medium suggest that, after the epoch of the electron-positron annihilation, magnetohydrodynamical configurations carrying a net magnetic helicity can be present. The simultaneous conservation of the magnetic flux and helicity implies that the (divergence free) field lines will possess inhomogeneous knot structures acting as source seeds in the evolution equations of the scalar, vector and tensor fluctuations of the background geometry. We give explicit examples of magnetic knot configurations with finite energy and we compute the induced metric fluctuations. Since magnetic knots are (conformally) coupled to gravity via the vertex dictated by the equivalence principle, they can imprint spikes in the gravitational wave spectrum for frequencies compatible with the typical scale of the knot corresponding, in our examples, to a present frequency range of $10^{-11}$--$10^{-12}$ Hertz. At lower frequencies the spectrum is power-suppressed and well below the COBE limit. For smaller length scales (i.e. for larger frequencies) the spectrum is exponentially suppressed and then irrelevant for the pulsar bounds. Depending upon the number of knots of the configuration, the typical amplitude of the gravitational wave logarithmic energy spectrum (in critical units) can be even four orders of magnitude larger than the usual flat (inflationary) energy spectrum generated thanks to the parametric amplification of the vacuum fluctuations.Comment: Accepted for publication in Physical Review D, 20 pages in RevTex style, 4 Encapsulated figure

Skeletal muscle ATP synthesis and cellular H+ handling measured by localized 31P-MRS during exercise and recovery

31P magnetic resonance spectroscopy (MRS) is widely used for non-invasive investigation of muscle metabolism dynamics. This study aims to extend knowledge on parameters derived from these measurements in detail and comprehensiveness: proton (H+) efflux, buffer capacity and the contributions of glycolytic (L) and oxidative (Q) rates to ATP synthesis were calculated from the evolutions of phosphocreatine (PCr) and pH. Data are reported for two muscles in the human calf, for each subject and over a wide range of exercise intensities. 22 subjects performed plantar flexions in a 7T MR-scanner, leading to PCr changes ranging from barely noticeable to almost complete depletion, depending on exercise protocol and muscle studied by localized MRS. Cytosolic buffer capacity was quantified for the first time non-invasively and individually, as was proton efflux evolution in early recovery. Acidification started once PCr depletion reached 60–75%. Initial and end-exercise L correlated with end-exercise levels of PCr and approximately linear with pH. Q calculated directly from PCr and pH derivatives was plausible, requiring fewer assumptions than the commonly used ADP-model. In conclusion, the evolution of parameters describing cellular energy metabolism was measured over a wide range of exercise intensities, revealing a relatively complete picture of muscle metabolism

ATP and its N6-substituted analogues: parameterization, molecular dynamics simulation and conformational analysis

In this work we used a combination of classical molecular dynamics and simulated annealing techniques to shed more light on the conformational flexibility of 12 adenosine triphosphate (ATP) analogues in a water environment. We present simulations in AMBER force field for ATP and 12 published analogues [Shah et al. (1997) Proc Natl Acad Sci USA 94: 3565–3570]. The calculations were carried out using the generalized Born (GB) solvation model in the presence of the cation Mg2+. The ion was placed at a close distance (2 Å) from the charged oxygen atoms of the beta and gamma phosphate groups of the −3 negatively charged ATP analogue molecules. Analysis of the results revealed the distribution of inter-proton distances H8–H1′ and H8–H2′ versus the torsion angle ψ (C4–N9-C1′–O4′) for all conformations of ATP analogues. There are two gaps in the distribution of torsion angle ψ values: the first is between −30 and 30 degrees and is described by cis-conformation; and the second is between 90 and 175 degrees, which mostly covers a region of anti conformation. Our results compare favorably with results obtained in experimental assays [Jiang and Mao (2002) Polyhedron 21:435–438]

C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media

BACKGROUND: Innate immunity and tissue proliferation play important roles in otitis media (OM), the most common disease of childhood. CJUN terminal kinase (JNK) is potentially involved in both processes. RESULTS: Genes involved in both innate immune and growth factor activation of JNK are upregulated during OM, while expression of both positive and negative JNK regulatory genes is altered. When compared to wildtypes (WTs), C57BL/6 mice deficient in JNK1 exhibit enhanced mucosal thickening, with delayed recovery, enhanced neutrophil recruitment early in OM, and delayed bacterial clearance. In contrast, JNK2(−/−) mice exhibit delayed mucosal hyperplasia that eventually exceeds that of WTs and is slow to recover, delayed recruitment of neutrophils, and failure of bacterial clearance. CONCLUSIONS: The results suggest that JNK1 and JNK2 play primarily opposing roles in mucosal hyperplasia and neutrophil recruitment early in OM. However, both isoforms are required for the normal resolution of middle ear infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12865-014-0046-z) contains supplementary material, which is available to authorized users

Innate Signaling in Otitis Media: Pathogenesis and Recovery

Otitis media (OM) is the most prevalent childhood disease in developed countries. Involvement of innate immunity mediated by Toll-like receptors (TLRs) in OM has been implicated primarily in cell lines and by association studies of innate immune gene polymorphisms with OM prevalence. However, the precise role of innate immunity in OM is incompletely understood. We review recent research that has advanced our understanding of how innate immunity in the middle ear is mediated by the interaction of pathogen molecules with receptors such as the TLRs, leading to the activation of adaptor molecules and production of proinflammatory cytokines. TLR genes and signaling molecules are upregulated in OM in a murine model. Deletion of several key innate immune genes results in persistent OM in mice, coupled with an inability to clear bacterial infection from the middle ear. It is concluded that an intact innate immune signaling system is critical to recovery from bacterial OM