The Uses and Effectiveness of Computers in Educational Administration

The purpose of this study was to assess the uses and effectiveness of computers in educational administration. Principals from the high schools of Washington State\u27s Mid-Valley AA League responded to a questionnaire regarding the uses of computers in their buildings and the perceived effectiveness of computers used for administrative tasks. Survey results indicated that the majority of high schools in the Mid-Valley AA League have used computers for common administrative tasks, and principals found that these tasks were accomplished more effectively with a computer

Role of Hypoxia in the Evolution and Development of the Cardiovascular System

Article on the role of hypoxia in the evolution and development of the cardiovascular system

Long gravitational-wave transients and associated detection strategies for a network of terrestrial interferometers

Searches for gravitational waves (GWs) traditionally focus on persistent sources (e.g., pulsars or the stochastic background) or on transients sources (e.g., compact binary inspirals or core-collapse supernovae), which last for time scales of milliseconds to seconds. We explore the possibility of long GW transients with unknown waveforms lasting from many seconds to weeks. We propose a novel analysis technique to bridge the gap between short O(s) “burst” analyses and persistent stochastic analyses. Our technique utilizes frequency-time maps of GW strain cross power between two spatially separated terrestrial GW detectors. The application of our cross power statistic to searches for GW transients is framed as a pattern recognition problem, and we discuss several pattern-recognition techniques. We demonstrate these techniques by recovering simulated GW signals in simulated detector noise. We also recover environmental noise artifacts, thereby demonstrating a novel technique for the identification of such artifacts in GW interferometers. We compare the efficiency of this framework to other techniques such as matched filtering

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

SummaryOsteoprotegerin (OPG) and receptor activator of nuclear factor κB (RANK) are members of the tumor necrosis factor receptor (TNFR) superfamily that regulate osteoclast formation and function by competing for RANK ligand (RANKL). RANKL promotes osteoclast development through RANK activation, while OPG inhibits this process by sequestering RANKL. For comparison, we solved crystal structures of RANKL with RANK and RANKL with OPG. Complementary biochemical and functional studies reveal that the monomeric cytokine-binding region of OPG binds RANKL with ∼500-fold higher affinity than RANK and inhibits RANKL-stimulated osteoclastogenesis ∼150 times more effectively, in part because the binding cleft of RANKL makes unique contacts with OPG. Several side chains as well as the C-D and D-E loops of RANKL occupy different orientations when bound to OPG versus RANK. High affinity OPG binding requires a 90s loop Phe residue that is mutated in juvenile Paget’s disease. These results suggest cytokine plasticity may help to fine-tune specific tumor necrosis factor (TNF)-family cytokine/receptor pair selectivity

Thermal Anomalies Detect Critical Global Land Surface Changes

Measurements that link surface conditions and climate can provide critical information on important biospheric changes occurring in the Earth system. As the direct driving force of energy and water fluxes at the surface–atmosphere interface, land surface temperature (LST) provides information on physical processes of land-cover change and energy-balance changes that air temperature cannot provide. Annual maximum LST (LSTmax) is especially powerful at minimizing synoptic and seasonal variability and highlighting changes associated with extreme climatic events and significant land-cover changes. The authors investigate whether maximum thermal anomalies from satellite observations could detect heat waves and droughts, a melting cryosphere, and disturbances in the tropical forest from 2003 to 2014. The 1-km2 LSTmax anomalies peaked in 2010 when 20% of the global land area experienced anomalies of greater than 1 standard deviation and over 4% of the global land area was subject to positive anomalies exceeding 2 standard deviations. Positive LSTmax anomalies display complex spatial patterns associated with heat waves and droughts across the global land area. The findings presented herein show that entire biomes are experiencing shifts in their LSTmax distributions driven by extreme climatic events and large-scale land surface changes, such as melting of ice sheets, severe droughts, and the incremental effects of forest loss in tropical forests. As climate warming and land-cover changes continue, it is likely that Earth’s maximum surface temperatures will experience greater and more frequent directional shifts, increasing the possibility that critical thresholds in Earth’s ecosystems and climate system will be surpassed, resulting in profound and irreversible changes

Solar Flare Impulsive Phase Observations from SDO and Other Observatories

With the start of normal operations of the Solar Dynamics Observatory in May 2010, the Extreme ultraviolet Variability Experiment (EVE) and the Atmospheric Imaging Assembly (AIA) have been returning the most accurate solar XUV and EUV measurements every 10 and 12 seconds, respectively, at almost 100% duty cycle. The focus of the presentation will be the solar flare impulsive phase observations provided by EVE and AIA and what these observations can tell us about the evolution of the initial phase of solar flares. Also emphasized throughout is how simultaneous observations with other instruments, such as RHESSI, SOHO-CDS, and HINODE-EIS, will help provide a more complete characterization of the solar flares and the evolution and energetics during the impulsive phase. These co-temporal observations from the other solar instruments can provide information such as extending the high temperature range spectra and images beyond that provided by the EUV and XUV wavelengths, provide electron density input into the lower atmosphere at the footpoints, and provide plasma flows of chromospheric evaporation, among other characteristics

VLA-ANGST: A high-resolution HI Survey of Nearby Dwarf Galaxies

We present the "Very Large Array survey of Advanced Camera for Surveys Nearby Galaxy Survey Treasury galaxies (VLA-ANGST)." VLA-ANGST is a National Radio Astronomy Observatory Large Program consisting of high spectral (0.6-2.6 km/s) and spatial (~6") resolution observations of neutral, atomic hydrogen (HI) emission toward 35 nearby dwarf galaxies from the ANGST survey. ANGST is a systematic HST survey to establish a legacy of uniform multi-color photometry of resolved stars for a volume-limited sample of nearby galaxies (D\lesssim4 Mpc). VLA-ANGST provides VLA HI observations of the sub-sample of ANGST galaxies with recent star formation that are observable from the northern hemisphere and that were not observed in the "The HI Nearby Galaxy Survey" (THINGS). The overarching scientific goal of VLA-ANGST is to investigate fundamental characteristics of the neutral interstellar medium (ISM) of dwarf galaxies. Here we describe the VLA observations, the data reduction, and the final VLA-ANGST data products. We present an atlas of the integrated HI maps, the intensity-weighted velocity fields, the second moment maps as a measure for the velocity dispersion of the HI, individual channel maps, and integrated HI spectra for each VLA-ANGST galaxy. We closely follow the observational setup and data reduction of THINGS to achieve comparable sensitivity and angular resolution. A major difference, however, is the high velocity resolution of the VLA-ANGST observations (0.65 and 1.3km/s for the majority of the galaxies). The VLA-ANGST data products are made publicly available at: https://science.nrao.edu/science/surveys/vla-angst. With available star formation histories from resolved stellar populations and lower resolution ancillary observations from the FIR to the UV, VLA-ANGST will enable detailed studies of the relationship between the ISM and star formation in dwarf galaxies on a ~100 pc scale.Comment: 64 figures, grouped into 32. 115 pages, accepted for publication in the Astronomical Journa