8 research outputs found
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Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
OBJECTIVE—Despite extensive evidence for genetic susceptibility
to diabetic nephropathy, the identification of susceptibility
genes and their variants has had limited success. To search for
genes that contribute to diabetic nephropathy, a genome-wide
association scan was implemented on the Genetics of Kidneys in
Diabetes collection.
RESEARCH DESIGN AND METHODS—We genotyped
360,000 single nucleotide polymorphisms (SNPs) in 820 case
subjects (284 with proteinuria and 536 with end-stage renal
disease) and 885 control subjects with type 1 diabetes. Confirmation
of implicated SNPs was sought in 1,304 participants of the
Diabetes Control and Complications Trial (DCCT)/Epidemiology
of Diabetes Interventions and Complications (EDIC) study, a
long-term, prospective investigation of the development of diabetes-
associated complications.
RESULTS—A total of 13 SNPs located in four genomic loci were
associated with diabetic nephropathy with P1105. The
strongest association was at the FRMD3 (4.1 protein ezrin,
radixin, moesin [FERM] domain containing 3) locus (odds ratio
[OR]1.45, P5.0107). A strong association was also
identified at the CARS (cysteinyl-tRNA synthetase) locus (OR
1.36, P3.1106). Associations between both loci and time to
onset of diabetic nephropathy were supported in the DCCT/EDIC
study (hazard ratio [HR]1.33, P0.02, and HR1.32, P
0.01, respectively). We demonstrated expression of both FRMD3
and CARS in human kidney.
CONCLUSIONS—We identified genetic associations for susceptibility
to diabetic nephropathy at two novel candidate loci near
the FRMD3 and CARS genes. Their identification implicates
previously unsuspected pathways in the pathogenesis of this
important late complication of type 1 diabetes
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Ethics Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Final Presentation Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Brochure2 Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Final Report Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Brochure1 Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable
Crisis Management and Security Program (CMS) (Semester Unknown) IPRO 370: Crisis Management and Security Program IPRO 370 Midterm Report Sp08
The IIT IPRO 370 Crisis Management and Security Program (CMS) is in its fourth stage of development. The current goal is to further develop the capabilities of our web based program that can be used by organizations to assist when determining how well their crisis management plans stand up to different methodologies, assessments, and scenarios during the testing process. Also to start marketing our web site to attract a community of many users to assist in the growth of the CMS program. The initial grant for this project was funded by the Homeland Security Innovation & Entrepreneurship Center. Ms. Irene Rozansky, CEO and founder of R&A Crisis Management Services Inc. will be our sponsor to ensure that we develop a program able to test existing crisis management plans for companies, organizations, and individuals who lack a response ready approach in times of crisis.Deliverable