Analysis and quantification of diagnostic serum markers and protein signatures for Gaucher disease

FWN – Publicaties zonder aanstelling Universiteit Leide

Comparison of spherically and irregularly shaped stationary phase packings in microcolumn liquid chromatography

Spherically and irregularly shaped reversed phase packings were used to slurry pack capillary fused silica columns. The selection of the packing solvents was based on the colloidal properties of the stationary phase particles and investigated by sedimentation experiments. The chromatographic performance of the microcolumns was measured with conventional parameters from plate and rate theories, and the column resistance parameter and separation impedance. Also studied was the time of analysis. The performance of spherical and irregular packings was comparable with a light preference for spherically shaped materials when time of analysis is concerned

Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards

Medical Biochemistr

Cov2MS: an automated and quantitative matrix-independent assay for mass spectrometric measurement of SARS-CoV-2 nucleocapsid protein

Analytical BioScience

The Hamaker and the Lifshitz approaches for the Van der Waals interaction between particles of composite materials dispersed in a medium

Based on the superpositional principle of the classical Hamaker–De Boer approach to the Van der Waals interaction, an equation for the interaction energy between two identical composite particles in a medium has been developed. The particles are supposed to be composed of an arbitrary number of components that are intimately mixed to avoid appreciable scattering of interacting EM waves. A discussion is presented on how intimately the components have to be mixed for the theory to be applicable. As an example, the main theoretical result is applied to porous polystyrene particles in water, while the pores are not filled with water (‘non-wetting surface’). Numerical results for composite particles are evaluated, using interaction parameters as obtained by various methods that are based on either the Hamaker–de Boer or the Lifshitz approach

The Hamaker and the Lifshitz approaches for the Van der Waals interaction between particles of composite materials dispersed in a medium

Based on the superpositional principle of the classical Hamaker–De Boer approach to the Van der Waals interaction, an equation for the interaction energy between two identical composite particles in a medium has been developed. The particles are supposed to be composed of an arbitrary number of components that are intimately mixed to avoid appreciable scattering of interacting EM waves. A discussion is presented on how intimately the components have to be mixed for the theory to be applicable. As an example, the main theoretical result is applied to porous polystyrene particles in water, while the pores are not filled with water (‘non-wetting surface’). Numerical results for composite particles are evaluated, using interaction parameters as obtained by various methods that are based on either the Hamaker–de Boer or the Lifshitz approach