2,469 research outputs found
Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies
We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future
Measurement of via initial state radiation at Belle
The process (=1, 2) is studied via initial
state radiation using 980 fb of data at and around the
(=1, 2, 3, 4, 5) resonances collected with the Belle detector at the KEKB
asymmetric-energy collider. No significant signal is observed except
from decays. Upper limits on the cross sections between
and are determined at the 90% credibility
level, which range from few pb to a few tens of pb. We also set upper limits on
the decay rate of the vector charmonium [), , and
] and charmoniumlike [, , and ] states
to .Comment: Accepted by PR
Evidence for B- -> Ds+ K- l- nubar and search for B- -> Ds*+ K- l- nubar
We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data
sample containing 657x10^6 BBbar pairs collected with the Belle detector at the
KEKB asymmetric-energy e+e- collider. We observe a signal with a significance
of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the
B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the
following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat)
+0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/-
0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l-
nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first
measurement of the Ds+K- invariant mass distribution in these decays, which is
dominated by a prominent peak around 2.6 GeV/c^2.Comment: Submitted to Phys. Rev.
Search for a massive invisible particle in and decays
We present a search for a non-Standard-Model invisible particle in the
mass range in and
decays. The results are obtained from a data sample that corresponds to pairs,
collected at the resonance with the Belle detector at the KEKB
collider. One meson is fully reconstructed in a hadronic mode to
determine the momentum of the lepton of the signal decay in the rest frame of
the recoiling partner meson. We find no evidence of a signal and set upper
limits on the order of .Comment: 8 pages, 4 figures, 3 table
Search for decays to invisible final states at Belle
We report a search for decays into invisible final states using a
data sample of pairs collected at the
resonance with the Belle detector at the KEKB
collider. The signal is identified by fully reconstructing a hadronic decay of
the accompanying meson and requiring no other particles in the event. No
significant signal is observed, and we obtain an upper limit of at the 90% confidence level for the branching fraction of invisible
decay.Comment: 6 pages, 5 figures (9 figure files
Search for B+ -> l+ nu gamma decays with hadronic tagging using the full Belle data sample
We search for the decay B+ -> l+ nu gamma with l+ = e+ or mu+ using the full
Belle data set of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with
the Belle detector at the KEKB asymmetric-energy e+e- collider. We reconstruct
one B meson in a hadronic decay mode and search for the B+ -> l+ nu gamma decay
in the remainder of the event. We observe no significant signal within the
phase space of E_gamma^sig > 1 GeV and obtain upper limits of BR(B+ -> e+ nu
gamma) mu+ nu gamma) l+ nu
gamma) < 3.5 x 10^-6 at 90 % credibility level.Comment: Submitted to Phys. Rev.
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