ЭЛЕКТРОФИЗИОЛОГИЧЕСКИЕ МЕТОДЫ В ДИАГНОСТИКЕ СУБКЛИНИЧЕСКИХ КОГНИТИВНЫХ НАРУШЕНИЙ У ВИЧ-ИНФИЦИРОВАННЫХ БОЛЬНЫХ

With a goal of the early detection of subclinical cognitive impairment and damage of the central nervous system in the early stages HIV infection the complex neurophysiological study (electroencephalogram, cognitive evoked potentials of auditory and visual modalities, complex sensory-motor reactions, visual evoked potentials) in 20 patients with HIV infection was performed. Electrophysiological signs of subclinical cognitive impairment and non-specific subclinical involvement of central nervous system were found. Application of the complex electrophysiological study by evaluating the function of widespread neuronal networks has allowed to increasing the sensitivity of early diagnosis of subclinical cognitive impairment in HIV-infected patients in 90% of cases.С целью раннего выявления субклинических когнитивных нарушений и поражения ЦНС у 20 пациентов с ВИЧ-инфекцией на ранних стадиях был проведен комплекс нейрофизиологических исследований: электроэнцефалограммы (ЭЭГ), когнитивных вызванных потенциалов мозга Р300 слуховой и зрительной модальностей, сложных сенсомоторных реакций, зрительных вызванных потенциалов и выявлены электрофизиологические признаки субклинических когнитивных нарушений и неспецифические электрофизиологические признаки субклинического поражения ЦНС. Применение расширенного комплекса электрофизиологических исследований с учетом специфики персистенции вируса в ЦНС позволило повысить чувствительность ранней диагностики субклинических когнитивных нарушений у ВИЧ-инфицированных больных до 90% случаев за счет оценки функции широко распространенных нейрональных сетей

Role of artrofoon in complex treatment of rheumatoid arthritis

Objective. To study influence of artrofoon on clinicolaboratory measures in pts with rheumatoid arthritis (RA). Material and methods. 119 RA pts (97 female, 22 male) were included. 104 of them were seropositive. Mean age was 52,3± 11,2 years, mean disease duration — 6,87+5,89 years. Disease activity level varied from 1 to 3 stage. Most pts had II or III radiological stage of RA. Usual clinical and laboratory examination of pts was performed at baseline and then after 1, 3, 6 and 12 months of treatment. Quantitative examination of serum cytokines was done using biochip technology method of Randox Laboratories Ltd (Great Britain). During the study all pts received standard treatment with disease modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs). The following NSAIDs were used: diclofenac in 54 pts (not more than 100 mg/day), nimesulid 200 mg/day in 37 pts, other NSAIDs - in 28 pts. The pts were divided into 2 groups. 91 pts of group 1 received artrofoon besides standard treatment. 28 pts of group 2 received only standard treatment. Results. Administration of artrofoon was accompanied by significant decrease of tumor necrosis factor a and interleukin (IL)ip levels after 3, 6 and 12 months of treatment, increase of IL4, IL10 and vascular endothelial growth factor to 6th month, decrease of epidermal growth factor to 12th month of treatment in comparison with control. These changes were accompanied by decrease of laboratory (ESR, CRP) and clinical measures of disease activity (VAS, Ritchie index, morning stiffness). Adverse events were absent in the main group of pts. Conclusion. Artrofoon exerted positive influence on the main clinicolaboratory and immunologic measures in pts with RA. Maximal effect was reached after 6 months of treatment. A part of pts decreased NSAID dose during treatment with artrofoon. The drug was well tolerated and safe during 12 months of treatment. Artrofoon can be administered with other drugs used in the treatment of RA

Electrophysiological methods in the diagnosis of subclinical cognitive impairment in HIV-infected patients

With a goal of the early detection of subclinical cognitive impairment and damage of the central nervous system in the early stages HIV infection the complex neurophysiological study (electroencephalogram, cognitive evoked potentials of auditory and visual modalities, complex sensory-motor reactions, visual evoked potentials) in 20 patients with HIV infection was performed. Electrophysiological signs of subclinical cognitive impairment and non-specific subclinical involvement of central nervous system were found. Application of the complex electrophysiological study by evaluating the function of widespread neuronal networks has allowed to increasing the sensitivity of early diagnosis of subclinical cognitive impairment in HIV-infected patients in 90% of cases

Experience with Karmolis liquid administration for rheumatic diseases local therapy (data of multicenter clinical examination)

Objective. To assess clinical efficacy and tolerability of "Karmolis" liquid (KL) in pts with osteoarthritis (OA) and rheumatoid arthritis (RA). Material and methods. 230 RA pts and 123 OA pts were included. KL was applied on the most damaged joint surface 10 ml 4-5 times a day with subsequent massage. The course of the treatment continued for three weeks. Joint pain at rest, at movement and at palpation so as joint swelling were used as efficacy measures. Treatment efficacy was assessed at day 1, 7, 14 and 21. Possibility of NSAID dose decrease was also recorded. Results. KL administration provided significant decrease of joint pain at rest, at movement and at palpation already to day 7 as in RA as in OA pts. The improvement then persisted during the rest period of treatment. Joint swelling disappeared to the end of the treatment in 141 from 209 RA pts having such changes at baseline. 74% of RA pts considered KL efficacy very good and good. Synovitis signs disappeared after the treatment with KL in 52 from 65 OA pts. Vfcry good and good results were achieved in 102 (83%) of OA pts. 76 RA pts (33%) and 73 OA pts (53%) could decrease NSAID dose. Adverse events were very seldom and did not require treatment termination. Conclusion. KL in effective in complex treatment of RA and OA. It decrease pain and inflammation and may be recommended for wide administration in the treatment of inflammatory and degenerative joint diseases

The physiotherapy method of the complex effect at the scar tissue

У статті запропонований метод впливу сумісними полями на тканинні структури організму з застосуванням медикаментозних засобів для ефективного лікування рубців.At work state at method of the complex fields effect of the tissue structures at used of the pharmacotherapy for the effective treatment of the scars.В статье предложен метод воздействия сочетанными полями на тканевые структуры организма с применением лекарственных средств для эффективного лечения рубцов