44 research outputs found
Role of Coulomb interaction in the superconducting properties of CaC6 and H under pressure
Superconductivity in intercalated graphite CaC6 and H under extreme pressure,
in the framework of superconducting density functional theory, is discussed. A
detailed analysis on how the electron-phonon and electron-electron interactions
combine together to determine the superconducting gap and critical temperature
of these systems is presented. In particular, we discuss the effect on the
calculated Tc of the anisotropy of the electron-phonon interaction and of the
different approximations for screening the Coulomb repulsion. These results
contribute to the understanding of multigap and anisotropic superconductivity,
which has received a lot of attention since the discovery of MgB2, and show how
it is possible to describe the superconducting properties of real materials on
a fully ab-initio basis.Comment: 13 pages, 5 figure
Low energy spin dynamics in the antiferromagnetic phase of CaFe2As2
We present 75As nuclear magnetic resonance data in the paramagnetic and
magnetic states of single crystal CaFe2As2. The electric field gradient and the
internal magnetic field at the As sites change discontinuously below the first
order structural transition at T0 = 169 K. In the magnetic state, we find a
single value of the internal hyperfine field consistent with commensurate
antiferromagnetic order of Fe moments pointing in the ab plane. The spin
lattice relaxation rate shows Korringa behavior for T<T0/3, reflecting the
metallic nature of the ordered state. Surprisingly, 1/T1 exhibits a small peak
at 10 K, revealing the presence of slow spin fluctuations that may be
associated with domain wall motion.Comment: 11 pages, 8 figure
Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus
Background: Gene profiling studies provide important information for key molecules relevant to a disease but are less informative of protein-protein interactions, post-translational modifications and regulation by targeted subcellular localization. Integration of genomic data and construction of functional gene networks may provide additional insights into complex diseases such as systemic lupus erythematosus (SLE). Methodology/Principal Findings: We analyzed gene expression microarray data of bone marrow mononuclear cells (BMMCs) from 20 SLE patients (11 with active disease) and 10 controls. Gene networks were constructed using the bioinformatic tool Ingenuity Gene Network Analysis. In SLE patients, comparative analysis of BMMCs genes revealed a network with 19 central nodes as major gene regulators including ERK, JNK, and p38 MAP kinases, insulin, Ca2+ and STAT3. Comparison between active versus inactive SLE identified 30 central nodes associated with immune response, protein synthesis, and post-transcriptional modification. A high degree of identity between networks in active SLE and non-Hodgkin's lymphoma (NHL) patients was found, with overlapping central nodes including kinases (MAPK, ERK, JNK, PKC), transcription factors (NF-kappaB, STAT3), and insulin. In validation studies, western blot analysis in splenic B cells from 5-month-old NZB/NZW F1 lupus mice showed activation of STAT3, ITGB2, HSPB1, ERK, JNK, p38, and p32 kinases, and downregulation of FOXO3 and VDR compared to normal C57Bl/6 mice. Conclusions/Significance: Gene network analysis of lupus BMMCs identified central gene regulators implicated in disease pathogenesis which could represent targets of novel therapies in human SLE. The high similarity between active SLE and NHL networks provides a molecular basis for the reported association of the former with lymphoid malignancies