Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation. However, other genes downstream of the Onecut proteins and involved in motor neuron diversification have remained unidentified. In the present study, we generated conditional mutant embryos carrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencing to identify factors downstream of Onecut proteins in this neuron population, and employed additional transgenic mouse models to assess the role of one specific Onecut-downstream target, the transcription factor Nkx6.2. Nkx6.2 expression was up-regulated in Onecut-deficient motor neurons, but strongly downregulated in Onecut-deficient V2a interneurons, indicating an opposite regulation of Nkx6.2 by Onecut factors in distinct spinal neuron populations. Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor network activity, likely resulting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons. Taken together, our results indicate that Nkx6.2 regulates the development of spinal neuronal populations and the formation of the spinal locomotor circuits downstream of the Onecut transcription factors

Self-harming behaviors in prison: a comparison of suicidal processes, self-injurious behaviors, and mixed events

Self-harming behaviors occurring in prison disproportionately consume resources and cause considerable disruption. To date, theoretical paradigms have explained self-injurious behaviors and suicidal processes either via a continuum or dichotomy of self-harm. This current study examines all documented acts of self-harm (n=1,158) occurring in South Carolina's 28 prisons over a 50 month period. We test and find support for a tripartite schema of self-harm; differentiated with regard to suicidal processes, self-injurious behaviors, and a 'mixed group' of self-harming behaviors. These groups of behaviors were distinct with regard to situational variables (i.e. body part targeted, injury severity) as well as institutional responses (i.e., medical treatment needed, employment of suicide protocols). Findings indicate that self-injurious behaviors are likely to result in physical injury and/or hospitalizations

Staff Perceptions of Risk for Prison Rape Perpetration and Victimization

Copyright © 2012 SAGE Publications, http://tpj.sagepub.com Used by permission

Violence today

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45468/1/11089_2005_Article_BF01768523.pd

A Literature Survey and Classifications on Data Deanonymisation

The problem of disclosing private anonymous data has become increasingly serious particularly with the possibility of carrying out deanonymisation attacks on publishing data. The related work available in the literature is inadequate in terms of the number of techniques analysed, and is limited to certain contexts such as Online Social Networks. We survey a large number of state-of-the-art techniques of deanonymisation achieved in various methods and on different types of data. Our aim is to build a comprehensive understanding about the problem. For this survey, we propose a framework to guide a thorough analysis and classifications. We are interested in classifying deanonymisation approaches based on type and source of auxiliary information and on the structure of target datasets. Moreover, potential attacks, threats and some suggested assistive techniques are identified. This can inform the research in gaining an understanding of the deanonymisation problem and assist in the advancement of privacy protection