2 research outputs found
Zika virus infection in pregnancy: a systematic review of disease course and complications
OBJECTIVES: To characterize maternal Zika virus (ZIKV) infection
and complement the evidence base for the WHO interim guidance on
pregnancy management in the context of ZIKV infection. METHODS:
We searched the relevant database from inception until March
2016. Two review authors independently screened and assessed
full texts of eligible reports and extracted data from relevant
studies. The quality of studies was assessed using the
Newcastle-Ottawa Scale (NOS) and the National Institute of
Health (NIH) tool for observational studies and case
series/reports, respectively. RESULTS: Among 142 eligible
full-text articles, 18 met the inclusion criteria (13 case
series/reports and five cohort studies). Common symptoms among
pregnant women with suspected/confirmed ZIKV infection were
fever, rash, and arthralgia. One case of Guillain-Barre syndrome
was reported among ZIKV-infected mothers, no other case of
severe maternal morbidity or mortality reported. Complications
reported in association with maternal ZIKV infection included a
broad range of fetal and newborn neurological and ocular
abnormalities; fetal growth restriction, stillbirth, and
perinatal death. Microcephaly was the primary neurological
complication reported in eight studies, with an incidence of
about 1% among newborns of ZIKV infected women in one study.
CONCLUSION: Given the extensive and variable fetal and newborn
presentations/complications associated with prenatal ZIKV
infection, and the dearth of information provided, knowledge
gaps are evident. Further research and comprehensive reporting
may provide a better understanding of ZIKV infection in
pregnancy and attendant maternal/fetal complications. This
knowledge could inform the creation of effective and
evidence-based strategies, guidelines and recommendations aimed
at the management of maternal ZIKV infection. Adherence to
current best practice guidelines for prenatal care among health
providers is encouraged, in the context of maternal ZIKV
infection
Zika virus infection in pregnancy: a systematic review of disease course and complications
OBJECTIVES: To characterize maternal Zika virus (ZIKV) infection
and complement the evidence base for the WHO interim guidance on
pregnancy management in the context of ZIKV infection. METHODS:
We searched the relevant database from inception until March
2016. Two review authors independently screened and assessed
full texts of eligible reports and extracted data from relevant
studies. The quality of studies was assessed using the
Newcastle-Ottawa Scale (NOS) and the National Institute of
Health (NIH) tool for observational studies and case
series/reports, respectively. RESULTS: Among 142 eligible
full-text articles, 18 met the inclusion criteria (13 case
series/reports and five cohort studies). Common symptoms among
pregnant women with suspected/confirmed ZIKV infection were
fever, rash, and arthralgia. One case of Guillain-Barre syndrome
was reported among ZIKV-infected mothers, no other case of
severe maternal morbidity or mortality reported. Complications
reported in association with maternal ZIKV infection included a
broad range of fetal and newborn neurological and ocular
abnormalities; fetal growth restriction, stillbirth, and
perinatal death. Microcephaly was the primary neurological
complication reported in eight studies, with an incidence of
about 1% among newborns of ZIKV infected women in one study.
CONCLUSION: Given the extensive and variable fetal and newborn
presentations/complications associated with prenatal ZIKV
infection, and the dearth of information provided, knowledge
gaps are evident. Further research and comprehensive reporting
may provide a better understanding of ZIKV infection in
pregnancy and attendant maternal/fetal complications. This
knowledge could inform the creation of effective and
evidence-based strategies, guidelines and recommendations aimed
at the management of maternal ZIKV infection. Adherence to
current best practice guidelines for prenatal care among health
providers is encouraged, in the context of maternal ZIKV
infection