第831回千葉医学会例会・第15回千葉大学放射線医学教室例会

Figure S2. All a-DMRs within (1) genomic location. Top: a-DMRs (purple), gene, DHS clusters, transcription factor ChIP-seq, ChromHMM segmentation, combined segmentation and conservation; and (2) scatterplot: x-axis = Age, y-axis = Normalised methylation. (PDF 34909 kb

Phenotypic, genetic and non-shared environmental correlations among CGT, AGI and sexual orientation (attraction).

<p>Phenotypic, genetic and non-shared environmental correlations among CGT, AGI and sexual orientation (attraction).</p

Best fitting common pathway model.

<p>The figure shows standardized parameter estimates for the path coefficients of the common pathway model, selected as the most appropriate depiction of the data. The squares of the path coefficients provide an estimate of the variance explained by common and specific genetic and environmental components.</p

Percentage of women that checked each item of sexual attraction along with means (and standard deviations) for their respective CGT and AGI scores.

<p>Percentage of women that checked each item of sexual attraction along with means (and standard deviations) for their respective CGT and AGI scores.</p

Means (and standard deviations) for continuous demographic variables, CGT, AGI and sexual orientation (attraction), along with frequency data for discrete demographics for the whole sample and by zygosity group.

<p>*Unpaired two-tailed <i>t</i>-test and Mann-Whitney U-tests were used to test for mean differences in response frequencies.</p><p>**Two-sample test of proportions were used to explore differences in response frequencies.</p

Multivariate analysis of three models showing change in model fit (<i>χ</i>2) and degrees of freedom (<i>df</i>) when specified parameters are dropped from full ADE model (best fitting models in bold).

<p>AIC = Akaike Information Criterion. AIC describes the model with best goodness-of-fit combined with parsimony. BIC = Bayesian Information Criterion. −2LL = likelihood ratio chi-square test as a measure of goodness of fit.</p

Intra-class correlations, cross-twin cross-trait correlations and heritabilities for CGT, AGI and both measures of sexual orientation.

<p>Heritability estimates and 95% CIs for all variables are calculated from the best-fitting, most parsimonious univariate AE model.</p><p>Note. Twin correlations for MZs/DZs are presented on the diagonal. Cross-twin cross-trait correlations for MZs are presented below the diagonal. Cross-twin cross-trait correlations for DZs are presented above the diagonal.</p

A spatially extended model for macroscopic spike-wave discharges

Spike-wave discharges are a distinctive feature of epileptic seizures. So far, they have not been reported in spatially extended neural field models. We study a space-independent version of the Amari neural field model with two competing inhibitory populations. We show that this competition leads to robust spike-wave dynamics if the inhibitory populations operate on different time-scales. The spike-wave oscillations present a fold/homoclinic type bursting. From this result we predict parameters of the extended Amari system where spike-wave oscillations produce a spatially homogeneous pattern. We propose this mechanism as a prototype of macroscopic epileptic spike-wave discharges. To our knowledge this is the first example of robust spike-wave patterns in a spatially extended neural field model

Additional file 1: of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Supplemental information. (PDF 5693 kb

Additional file 4: Table S3. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

T1D-associated SNPs used for risk score calculation. Related to Fig. 7. (XLSX 49 kb