D'Est en Ouest, Projet d'échange et d'exposition : Volet 1, Montréal : Itinéraires urbains

In a catalogue that unfolds like a poster, Théoret examines the theme of urban context and presents the work of three Montreal artists associated here with the parameters of space, density, and heterogeneity. Biographical notes

Historique de Skol, 1984-1995 par Yves Théoret : Commentaires de Anne-Marie Proulx et Sabina Russo

Written by Yves Théoret in 1995 while completing his Master’s degree in Museology, and while a member of the Board of directors of Skol, the Historique de Skol 1984-1995 was to be published as part of Skol’s 10th anniversary festivities in 1996. Théoret’s manuscript, finally published in 2011, is now accompanied by notes written in the margins by Sabrina Russo and Anne-Marie Proulx. The project is introduced in a preface by Proulx titled “The Story of a Little History”. The publication contains a bibliography dating from 1995, as well as an annex listing the events and activities of Skol Gallery (1984-1986) and of Centre des arts actuels Skol (1986-1995). The publication Historique de Skol commenté was edited by Centre des arts actuels Skol and accompanied the group exhibition Sortons les archives/Embracing the Archives presented at Skol from November 4 to December 17, 2011

Spectres infrarouges des oligoglycines et oligo-L-alanines,

Les spectres infrarouges des oligoglycinesH3N+(CH2CONH)nCH2COO-avec 1 ≤ n ≤ 4, des oligo-L-alaninesH3N+[CH(CH3)CONH]nCH(CH3)COO-avec 1 ≤ n ≤ 5, de quelques-uns de leurs dérivés N-deutériés et de la β-poly-L-alanine sont analysés. L’analogie des spectres des oligopeptides et des polypeptides en conformation β suggère que ces oligopeptides adoptent, à l’état solide, une conformation étendue

D'Est en Ouest = West in East

Catalogue documenting a two-point exchange carried out in two exhibitions bringing together three Montreal artists in Kelowna and Vernon (British Columbia), and six artists from the Kelowna area in Montreal. Curators Théoret and Macklem each present their own project in a short text (in French and English), followed by artists' statements and more specific commentaries on each work (both in the original language only). Biographical notes on curators and artists, including additional statements by the latter

Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT

Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation

The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

Busulfan (Bu) is a common component of conditioning regimens before hematopoietic stem cell transplantation (HSCT) and is known for high interpatient pharmacokinetic (PK) variability. This study aimed to develop and externally validate a multicentric, population PK (PopPK) model for intravenous Bu in pediatric patients before HSCT to first study the influence of glutathione-s-transferase A1 (GSTA1) polymorphisms on Bu's PK in a large multicentric pediatric population while accounting for fludarabine (Flu) coadministration and, second, to establish an individualized, model-based, first-dose recommendation for intravenous Bu that can be widely used in pediatric patients. The model was built using data from 302 patients from five transplantation centers who received a Bu-based conditioning regimen. External model validation used data from 100 patients. The relationship between body weight and Bu clearance (CL) was best described by an age-dependent allometric scaling of a body weight model. A stepwise covariate analysis identified Day 1 of Bu conditioning, GSTA1 metabolic groups based on GSTA1 polymorphisms, and Flu coadministration as significant covariates influencing Bu CL. The final model adequately predicted Bu first-dose CL in the external cohort, with 81% of predicted area under the curves within the therapeutic window. The final model showed minimal bias (mean prediction error, -0.5%; 95% confidence interval [CI], -3.1% to 2.0%) and acceptable precision (mean absolute prediction error percentage, 18.7%; 95% CI, 17.0%-20.5%) in Bu CL prediction for dosing. This multicentric PopPK study confirmed the influence of GSTA1 polymorphisms and Flu coadministration on Bu CL. The developed model accurately predicted Bu CL and first doses in an external cohort of pediatric patients