3 research outputs found
The relationship between genotypic variation at <i>ADRA2A</i> rs1800544 and the low-frequency RT fluctuation measure Slow-5.
<p>Relative power in the Slow-5 band (%) increased with each copy of the G allele.</p
The influence of COMT/val158met and ADRA2A gene variants on low-frequency fluctuation measures Slow-4 and Slow-5.
<p>The influence of COMT/val158met and ADRA2A gene variants on low-frequency fluctuation measures Slow-4 and Slow-5.</p
Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11)
<p><b>Objectives:</b> Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11)</p> <p><b>Methods:</b> Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison.</p> <p><b>Results:</b> Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele.</p> <p><b>Conclusions:</b> These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.</p