<原著>閉塞性脳血管障害患者に対するMR脳血管撮影法とX線脳血管撮影法との比較

MRI angiography and x-ray conventional angiography was performed in 10 patients with ischemic cerebral diseases. In 3 patients, MRI angiography showed narrowing or occlusion of main intracranial arterial trunks, but x-ray angiography confirmed these findings only in one patient. In two other patients, narrowing or occlusion was not observed. Also, no narrowing or occlusion was observed on x-ray angiography, when MRI angiography showed normal findings . It was concluded that MRI angiography was sensitive investigation, when intracerebral occlusive disease was suspected.我々は閉塞性脳血管障害患者10例に対して MR 脳血管撮影と X 線脳血管撮影を施行し比較したので報告する. MR 脳血管撮影は島津1. 5T 機種を用いた. 結果は (1) M R脳血管撮影, X 線脳血管撮影ともに正常6例があった. (2) MR 脳血管撮影において狭窄変化が認められた4例中, X 線脳血管撮影では1例のみ相応する変化が認められた, しかし3例は相応する変化は認められなかった. (3) MR 脳血管撮影正常でありながら, X 線脳血管撮影異常例はなかった. 異常のことより MR 脳血管撮影は閉塞性脳血管障害のスクリーニング検査として十分に敏感であり, かつ有用である

Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases

Background: Epstein Barr virus (EBV) has been suspected of being involved in the development of atopy. There are several studies suggesting a positive as well as negative association between EBV infection and atopic diseases. Here, we carried out a large-scale, systematic investigation to address the issue of the possible association between EBV infection and atopic diseases. Methods: Anti-EBV-viral capsid antigen (VCA) antibody titer, anti-EBV nuclear antigen (EBNA) antibody titer, atypical lymphocyte (AtLy) count and EBV-DNA copy number in 106 WBC were examined as evidence for EBV infection, and characteristic parameters of atopic disease such as total serum immunoglobulin E (IgE) level, highest antigen-specific IgE antibody titer (h-RAST) and peripheral blood eosinophil (Eos) count were measured and compared among atopic subjects and non-atopic controls, and correlations between parameters of atopy and EBV infection were subjected to statistical analysis. Results: Anti-EBV, in particular anti-EBNA antibody titer and AtLy count in peripheral blood were markedly higher in patients with bronchial asthma (BA) and/or atopic dermatitis (AD) than in non-atopic controls, especially in early childhood. No similar findings were obtained for antibodies to cytomegalovirus (CMV). EBV-DNA copy numbers in WBC were elevated in atopic subjects. Correlations between EBV-DNA copy number and other parameters of EBV infection (anti-EBV antibody titer and AtLy count) but those with cytomegalovirus (CMV) infection and markers of atopic disease (IgE, h-RAST level, and Eos count) were demonstrated. It was found that anti-EBNA seronegative atopics have higher copy numbers of EBV DNA in WBC and more elevated levels of IgE and h-RAST than anti-EBNA seropositive atopics. Anti-EBV VCA antibody titer in individuals aged 15 years and younger and anti-EBNA antibody titer among Japanese were suggested to have declined considerably in the past 15 years. Conclusions: The present study suggests that EBV infection in early childhood could precipitate atopic diseases