Development of Large area Gamma-ray Camera with GSO(Ce) Scintillator Arrays and PSPMTs

We have developed a position-sensitive scintillation camera with a large area absorber for use as an advanced Compton gamma-ray camera. At first we tested GSO(Ce) crystals. We compared light output from the GSO(Ce) crystals under various conditions: the method of surface polishing, the concentration of Ce, and co-doping Zr. As a result, we chose the GSO(Ce) crystals doped with only 0.5 mol% Ce, and its surface polished by chemical etching as the scintillator of our camera. We also made a 16$\times$16 cm$^2$ scintillation camera which consisted of 9 position-sensitive PMTs (PSPMTs Hamamatsu flat-panel H8500), the each of which had 8$\times$8 anodes with a pitch of 6 mm and coupled to 8$\times$8 arrays of pixelated 6$\times6\times$13 mm$^3$ GSO(Ce) scintillators. For the readout system of the 576 anodes of the PMTs, we used chained resistors to reduce the number of readout channels down to 48 to reduce power consumption. The camera has a position resolution of less than 6mm and a typical energy resolution of 10.5% (FWHM) at 662 keV at each pixel in a large area of 16$\times$16 cm$^2$. %to choose the best scintillator for our project. Furthermore we constructed a 16$\times$16 array of 3$\times3\times$13 mm$^3$ pixelated GSO(Ce) scintillators, and glued it to a PMT H8500. This camera had the position resolution of less than 3mm, over an area of 5$\times$5 cm$^2$, except for some of the edge pixels; the energy resolution was typically 13% (FWHM) at 662 keV.Comment: Proceedings of PSD7 appear in NIM

Cell transplantation to restore lost auditory nerve function is a realistic clinical opportunity

Hearing is one of our most important means of communication. Disabling hearing loss (DHL) is a long-standing, unmet problem in medicine, and in many elderly people, it leads to social isolation, depression, and even dementia. Traditionally, major efforts to cure DHL have focused on hair cells (HCs). However, the auditory nerve is also important because it transmits electrical signals generated by HCs to the brainstem. Its function is critical for the success of cochlear implants as well as for future therapies for HC regeneration. Over the past two decades, cell transplantation has emerged as a promising therapeutic option for restoring lost auditory nerve function, and two independent studies on animal models show that cell transplantation can lead to functional recovery. In this article, we consider the approaches most likely to achieve success in the clinic. We conclude that the structure and biochemical integrity of the auditory nerve is critical and that it is important to preserve the remaining neural scaffold, and in particular the glial scar, for the functional integration of donor cells. To exploit the natural, autologous cell scaffold and to minimize the deleterious effects of surgery, donor cells can be placed relatively easily on the surface of the nerve endoscopically. In this context, the selection of donor cells is a critical issue. Nevertheless, there is now a very realistic possibility for clinical application of cell transplantation for several different types of hearing loss

Development of an advanced Compton camera with gaseous TPC and scintillator

A prototype of the MeV gamma-ray imaging camera based on the full reconstruction of the Compton process has been developed. This camera consists of a micro-TPC that is a gaseous Time Projection Chamber (TPC) and scintillation cameras. With the information of the recoil electrons and the scattered gamma-rays, this camera detects the energy and incident direction of each incident gamma-ray. We developed a prototype of the MeV gamma-ray camera with a micro-TPC and a NaI(Tl) scintillator, and succeeded in reconstructing the gamma-rays from 0.3 MeV to 1.3 MeV. Measured angular resolutions of ARM (Angular Resolution Measure) and SPD (Scatter Plane Deviation) for 356 keV gamma-rays were $18^\circ$ and $35^\circ$, respectively.Comment: 4 pages, 5 figures. Proceedings of the 6th International Workshop On Radiation Imaging Detector

Studies of the performance of different front-end systems for flat-panel multi-anode PMTs with CsI(Tl) scintillator arrays

We have studied the performance of two different types of front-end systems for our gamma camera based on Hamamatsu H8500 (flat-panel 64 channels multi-anode PSPMT) with a CsI(Tl) scintillator array. The array consists of 64 pixels of $6\times6\times20{\rm mm}^3$ which corresponds to the anode pixels of H8500. One of the system is based on commercial ASIC chips in order to readout every anode. The others are based on resistive charge divider network between anodes to reduce readout channels. In both systems, each pixel (6mm) was clearly resolved by flood field irradiation of $^{137}$Cs. We also investigated the energy resolution of these systems and showed the performance of the cascade connection of resistive network between some PMTs for large area detectors.Comment: 9 pages, 6 figures, proceedings of the 7th International Workshop on Radiation Imaging Detectors (IWORID7), submitted to NIM

Laboratory study on heterogeneous decomposition of methyl chloroform on various standard aluminosilica clay minerals as a potential tropospheric sink

International audienceMethyl chloroform (1,1,1-trichloroethane, CH3CCl3) was found to decompose heterogeneously on seven types of standard clay minerals (23 materials) in dry air at 313 K in the laboratory. All reactions proceeded through the elimination of HCl; CH3CCl3 was converted quantitatively to CH2=CCl2. The activities of the clay minerals were compared via their pseudo-first-order reaction rate constants (k1). A positive correlation was observed between the k1 value and the specific surface area (S) of clay minerals, where the S value was determined by means of the general Brunauer-Emmett-Teller (BET) equation. The k1 value was anti-correlated with the value of n, which was a parameter of the general BET equation and related to the average pore size of the clay minerals, and correlated with the water content that can be removed easily from the clay minerals. The reaction required no special pretreatment of clay minerals, such as heating at high temperatures; hence, the reaction can be expected to occur in the environment. Photoillumination by wavelengths present in the troposphere did not accelerate the decomposition of CH3CCl3, but it induced heterogeneous photodecomposition of CH2=CCl2. The temperature dependence of k1, the adsorption equilibrium coefficient of CH3CCl3 and CH2=CCl2, and the surface reaction rate constant of CH3CCl3 were determined for an illite sample. The k1 value increased with increasing temperature. The amount of CH3CCl3 adsorbed on the illite during the reaction was proportional to the partial pressure of CH3CCl3. The reaction was sensitive to relative humidity and the k1 value decreased with increasing relative humidity. However, the reaction was found to proceed at a relative humidity of 22% at 313 K, although the k1 value was about one-twentieth of the value in non-humidified air. The conditions required for the reaction may be present in major desert regions of the world. A simple estimation indicates that the possible heterogeneous decomposition of CH3CCl3 on the ground surface in arid regions is worth taking into consideration when inferring the tropospheric lifetime of CH3CCl3 and global OH concentration from the global budget concentration of CH3CCl3

Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

SummaryObjectiveThe induction of synovial tissue to the meniscal lesion is crucial for meniscal healing. Synovial Mesenchymal stem cells (MSCs) are an attractive cell source because of their high proliferative and chondrogenic potentials. We examined whether transplantation of synovial MSCs promoted healing after meniscal repair of extended longitudinal tear of avascular area in a microminipig model.DesignLongitudinal tear lesion was made in medial menisci and sutured in both knees, and then a synovial MSC suspension was administered for 10 min only in unilateral knee. The sutured meniscus was evaluated morphologically and biomechanically at 2, 4, and 12 weeks. The behavior of transplanted MSCs was also examined.ResultsThe meniscal healing at 12 weeks was significantly better in the MSC group than in the control group; macroscopically, histologically and by T1rho mapping analysis. Transmission electron microscopic analysis demonstrated that the meniscus lesion was occupied by dense collagen fibrils only in the MSC group. Biomechanical analysis revealed that the tensile strength to failure of the meniscus higher in the MSC group than in the control group in each microminipig. Synovial tissue covered better along the superficial layer from the outer zone into the lesion of the meniscus in the MSC group at 2 and 4 weeks in each microminipig. Synovial MSCs labeled with ferucarbotran were detected in the meniscus lesion and adjacent synovium by MRI at 2 weeks.ConclusionTransplantation of synovial MSCs promoted healing after meniscal repair with induction of synovium into the longitudinal tear in the avascular zone of meniscus in pigs