Physiological studies on the effects of hormonal imbalance on the central nervous system

The acetylcholinesterase activity, RNA levels, total free amino acids and magnesium content in fore-, mid- and hind-brain were determined in the normal and hypophysectomised frogs (Rana cyanophlyctus). Hypophysectomy results in a marked decrease in the freea−a and in Mg. RNA also decreases significantly, but not to the same degree as thea−a and Mg. But AchE levels do not change significantly although there is a general decrease. It is suggested that the decrease in Mg is a reflection of the ionic imbalance resulting from hormonal imbalance. Hypophysectomy also results in reduced protein synthesis (and/or turnover) in the CNS as indicated by reduced RNA anda−a

Physiological studies on the effects of hormonal imbalance on the central nervous system. I. Effects of hypophysectomy on certain biochemical parameters in the brain of frog

Hypophysectomy resulted in a marked decrease in the free amino acid and Mg contents of fore-​, mid-​, and hindbrain segments. RNA levels and acetylcholinesterase activity decreased to a lesser extent

Rakshak - A Rescue Bot

Robotics is the field of designing and innovation that assumes a vital part in making our lives simpler to perform different undertakings. The primary point of the venture is to outline and build up, a sensor based mechanical arm which is controlled by human hand. The venture manages controlling a servo mechanical arm with the assistance of movement detecting innovation by Flex sensor and 3-hub accelerometer. The pick and place operation of the mechanical arm can be controlled utilizing Arduino. This framework can be utilized as a part of enterprises, dangerous conditions, biomedical surgeries and different applications

Antisteroidogenic activity of floral extract of <i>Thespesia populnea </i>Corr. in <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">mouse ovary</span>

1241-1242Anti-steroidogenic activity of various extracts of T.populnea was screened in female albino mice. The weight of the uterus and ovaries were reduced significantly and the cholesterol and ascorbic acid content in ovaries were significantly elevated due to the treatment with extract of T. populnea. The significant inhibition of Δ5 , 3β hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase, the two key enzymes involved in ovarian steroidogenesis were also observed in mouse ovaries after 15 days of treatment

Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis

Cerebral venous thrombosis developing concurrently with active ulcerative colitis poses a therapeutic dilemma. We report the case of a 31-year-old woman who developed dural venous sinus thrombosis during the course of active ulcerative colitis in whom we accomplished clot lysis using intrasinus urokinase. The success of the procedure was assessed by improvement in the patient's neurological condition and resolution of imaging features without any bleeding complications. We also reviewed literature on various modalities of treatment of sinus venous thrombosis in patients with ulcerative colitis and outcome

Predictors of major neurological improvement after intravenous thrombolysis in acute ischemic stroke: A hospital-based study from south India

Background : Despite the increasing use of recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke, uncertainty persists about the short- and long-term outcome of the thrombolysed patients. Objective : To identify predictors of major neurological improvement at 24 h after intravenous rt-PA administration in patients of acute ischemic stroke and their relationship with outcome at 12 months. Materials and Methods : We analyzed the data of the patients with acute ischemic stroke treated as per the National Institute of Neurological Disorders and Stroke (NINDS) criteria with intravenous rt-PA between January 2000 and June 2009 at a tertiary care center in south India. Major neurological improvement was defined by an 8-point improvement in National Institute of Health Stroke Scale (NIHSS) score or an NIHSS score of 0 or 1 at 24 h. Good outcome was defined as a 12-month modified Rankin Scale (mRS) of 0 to 1. Results : Of the 72 patients with acute ischemic stroke treated with intravenous rt-PA, 23 (32%) patients had major neurological improvement at 24 h. Age <60 years (OR 1.9, 95% CI 1.7 to3.2), admission glucose levels <8 mmol/L (OR 3.87, 95% CI 1.9 to 9.2) and mild to moderate baseline stroke severity (NIHSS median score 10+ 6) were associated with major neurological improvement after adjusting for co variables. Major neurological improvement at 24 h was an independent predictor of good outcome (mRS=1) at 12 months (OR 13.9, 95% CI 6.84 to 40.2). Conclusions : Age <60 years, glucose levels <8 mmol/L and mild to moderate stroke severity (NIHSS median score 10±6) was associated with major neurological improvement after intravenous rt-PA. Major neurological improvement at 24 h after the administration of intravenous thrombolysis independently predicted good outcome at 12 months