Characterization of some aflatoxin-deficient mutants of Aspergillus parasiticus

Aflatoxins are polyketide secondary metabolites produced by isolates of Aspergillus flavus and A. parasiticus. Since 1960, when a wide toxic outbreak was associated with moldy feed contaminated with aflatoxins, many efforts have been concentrated on this topic because of both the carcinogenic properties of these mycotoxins, and the worldwide occurrence of aflatoxin-producing fungi in cereal, cereal products and other agricultural commodities

Quantum correlations versus Multisimultaneity: an experimental test

Multisimultaneity is a causal model of relativistic quantum physics which assigns a real time ordering to any set of events, much in the spirit of the pilot-wave picture. Contrary to standard quantum mechanics, it predicts a disappearance of the correlations in a Bell-type experiment when both analysers are in relative motion such that, each one in its own inertial reference frame, is first to select the output of the photons. We tested this prediction using acousto-optic modulators as moving beam-splitters and interferometers separated by 55 m. We didn't observe any disappearance of the correlations, thus refuting Multisimultaneity.Comment: 4 pages, 3 figures, RevTex 4 versio

Weak Measurements in Non-Hermitian Systems

"Weak measurements" -- involving a weak unitary interaction between a quantum system and a meter followed by a projective measurement -- are investigated when the system has a non-Hermitian Hamiltonian. We show in particular how the standard definition of the "weak value" of an observable must be modified. These studies are undertaken in the context of bound state scattering theory, a non-Hermitian formalism for which the Hilbert spaces involved are unambiguously defined and the metric operators can be explicitly computed. Numerical examples are given for a model system

Surgical management of “ab-extrinseco” main stem left coronary compression during pulmonary thromboendarterectomy

Extrinsic compression of the left main coronary artery (LMCA) is a common but often underestimated complication of severe pulmonary hypertension (PH) and resulting pulmonary artery (PA) dilatatio

Ventricular assist devices implantation: surgical assessment and technical strategies

Along with the worldwide increase in continuous left ventricular assist device (LVAD) strategy adoption, more and more patients with demanding anatomical and clinical features are currently referred to heart failure (HF) departments for treatment. Thus surgeons have to deal, technically, with re-entry due to previous cardiac surgery procedures, porcelain aorta, peripheral vascular arterial disease, concomitant valvular or septal disease, biventricular failure. New surgical techniques and surgical tools have been developed to offer acceptable postoperative outcomes to all mechanical circulatory support recipients. Several less invasive and/or thoracotomic approaches for surgery combined with various LVAD inflow and outflow graft alternative anastomotic sites for system placement have been reported and described to solve complex clinical scenarios. Surgical techniques have been upgraded with further technical tips to preserve the native anatomy in case of re-entry for heart transplantation, myocardial recovery or device explant. The current continuous-flow miniaturized and intrapericardial devices provide versatility and technical advantages. However, the surgical planning requires a careful multidisciplinary evaluation which must be driven by a dedicated and well-trained Heart Failure team. Biventricular assist device (BVAD) implantation by adoption of the newer radial pumps might be a challenge. However, the results are encouraging thus remaining a valid option. This paper reviews and summarizes LVAD preoperative assessment and current surgical techniques for implantation

Abundance trend with condensation temperature for stars with different Galactic birth places

During the past decade, several studies reported a correlation between chemical abundances of stars and condensation temperature (also known as Tc trend). However, the real astrophysical nature of this correlation is still debated. The main goal of this work is to explore the possible dependence of the Tc trend on stellar Galactocentric distances, Rmean. We used high-quality spectra of about 40 stars observed with the HARPS and UVES spectrographs to derive precise stellar parameters, chemical abundances, and stellar ages. A differential line-by-line analysis was applied to achieve the highest possible precision in the chemical abundances. We confirm previous results that [X/Fe] abundance ratios depend on stellar age and that for a given age, some elements also show a dependence on Rmean. When using the whole sample of stars, we observe a weak hint that the Tc trend depends on Rmean. The observed dependence is very complex and disappears when only stars with similar ages are considered. To conclude on the possible dependence of the Tc trend on the formation place of stars, a larger sample of stars with very similar atmospheric parameters and stellar ages observed at different Galactocentric distances is neededComment: Accepted by A&

Relativity and EPR Entanglement: Comments

Recent experiment by Zhinden et al (Phys. Rev {\bf A} 63 02111, 2001) purports to test compatibility between relativity and quantum mechanics in the classic EPR setting. We argue that relativity has no role in the EPR argument based solely on non-relativistic quantum formalism. It is suggested that this interesting experiment may have significance to address fundamental questions on quantum probability.Comment: 6 pages, no figure; Submitted to Phys. Rev.

First-Principles Study of Substitutional Metal Impurities in Graphene: Structural, Electronic and Magnetic Properties

We present a theoretical study using density functional calculations of the structural, electronic and magnetic properties of 3d transition metal, noble metal and Zn atoms interacting with carbon monovacancies in graphene. We pay special attention to the electronic and magnetic properties of these substitutional impurities and found that they can be fully understood using a simple model based on the hybridization between the states of the metal atom, particularly the d shell, and the defect levels associated with an unreconstructed D3h carbon vacancy. We identify three different regimes associated with the occupation of different carbon-metal hybridized electronic levels: (i) bonding states are completely filled for Sc and Ti, and these impurities are non-magnetic; (ii) the non-bonding d shell is partially occupied for V, Cr and Mn and, correspondingly, these impurties present large and localized spin moments; (iii) antibonding states with increasing carbon character are progressively filled for Co, Ni, the noble metals and Zn. The spin moments of these impurities oscillate between 0 and 1 Bohr magnetons and are increasingly delocalized. The substitutional Zn suffers a Jahn-Teller-like distortion from the C3v symmetry and, as a consequence, has a zero spin moment. Fe occupies a distinct position at the border between regimes (ii) and (iii) and shows a more complex behavior: while is non-magnetic at the level of GGA calculations, its spin moment can be switched on using GGA+U calculations with moderate values of the U parameter.Comment: 13 figures, 4 tables. Submitted to Phys. Rev. B on September 26th, 200

ESMO Clinical Practice Guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma

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