Very Long Baseline Array Imaging of Type-2 Seyferts with Double-Peaked Narrow Emission Lines: Searches for Sub-kpc Dual AGNs and Jet-Powered Outflows

This paper presents Very Long Baseline Array (VLBA) observations of 13 double-peaked [O III] emission-line type-2 Active Galactic Nuclei (AGNs) at redshifts 0.06 < z < 0.41 (with a median redshift of z~0.15) identified in the Sloan Digital Sky Survey. Such double-peaked emission-line objects may result from jets or outflows from the central engine or from a dual AGN. The VLBA provides an angular resolution of <~10 pc at the distance of many of these galaxies, sufficient to resolve the radio emission from extremely close dual AGNs and to contribute to understanding the origin of double-peaked [O III] emission lines. Of the 13 galaxies observed at 3.6 cm (8.4 GHz), we detect six at a 1\sigma\ sensitivity level of ~0.15 mJy/beam, two of which show clear jet structures on scales ranging from a few milliarcseconds to tens of milliarcseconds (corresponding to a few pc to tens of pc at a median redshift of 0.15). We suggest that radio-loud double-peaked emission-line type-2 AGNs may be indicative of jet produced structures, but a larger sample of double-peaked [O III] AGNs with high angular resolution radio observations will be required to confirm this suggestion.Comment: 14 pages, 7 figures; ApJ in pres

Metal additive manufacturing and powder metallurgy

Additive manufacturing is older than most people recognize. The state of the art Metal Additive industry of today was brought about by various technological advances in related fields such as laser technology and CAD/CAM systems. This presentation will offer a broad overview of the history of Metal Additive Manufacturing and provide an introduction into various processes utilizing metal powders. It will also explore uses of the technology and begin the conversation about where and when AM technologies appear to be useful. This dynamic field changes almost daily and new technologies or ideas are constantly evolving, but this presentation should provide a basic understanding

Laser Additive Manufacturing Process of a Mixture of Iron and Nickel Powders

Laser-based powder bed additive manufacturing (AM) of metal powders uses pre-alloyed powder, which limits the alloys available for processing. Other processes using metal powders such as powder metallurgy (PM) (press and sinter and MIM (Metal Injection Molding)) and welding use elemental powder mixtures to produce a wide variety of alloy compositions. This study tests the ability of laser AM to produce a homogeneous alloy from a mixture of powders.Mechanical Engineerin

Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks

Genome-wide expression profiling of spore germination in Saccharomyces cerevisiae reveals two major stages and identifies germination-specific regulation of cell cycle machinery

Dynamics of chromatin and transcription during transient depletion of the RSC chromatin remodeling complex

Nucleosome organization has a key role in transcriptional regulation, yet the precise mechanisms establishing nucleosome locations and their effect on transcription are unclear. Here, we use an induced degradation system to screen all yeast ATP-dependent chromatin remodelers. We characterize how rapid clearance of the remodeler affects nucleosome locations. Specifically, depletion of Sth1, the catalytic subunit of the RSC (remodel the structure of chromatin) complex, leads to rapid fill-in of nucleosome-free regions at gene promoters. These changes are reversible upon reintroduction of Sth1 and do not depend on DNA replication. RSC-dependent nucleosome positioning is pivotal in maintaining promoters of lowly expressed genes free from nucleosomes. In contrast, we observe that upon acute stress, the RSC is not necessary for the transcriptional response. Moreover, RSC-dependent nucleosome positions are tightly related to usage of specific transcription start sites. Our results suggest organizational principles that determine nucleosome positions with and without RSC and how these interact with the transcriptional process

Retinal Architecture in ​\u3cem\u3eRGS9-\u3c/em\u3e and ​\u3cem\u3eR9AP\u3c/em\u3e-Associated Retinal Dysfunction (Bradyopsia)

Purpose To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy. Design Observational case series. Methods setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy. Results Cone density at 100 μm from foveal center ranged from 123 132 cones/mm2to 140 013 cones/mm2. Cone density ranged from 30 573 to 34 876 cones/mm2 by 600 μm from center and from 15 987 to 16,253 cones/mm2 by 1400 μm from center, in keeping with data from normal subjects. Adaptive-optics imaging identified a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-associated disease, corresponding to a discrete outer retinal defect also observed on spectral-domain optical coherence tomography; however, the photoreceptor mosaic remained intact at all other observed eccentricities. Conclusions Bradyopsia and oligocone trichromacy share common clinical symptoms and cannot be discerned on standard clinical findings alone. Adaptive-optics imaging previously demonstrated a sparse mosaic of normal wave-guiding cones remaining at the fovea, with no visible structure outside the central fovea in oligocone trichromacy. In contrast, the subjects presented in this study with molecularly confirmed bradyopsia had a relatively intact and structurally normal photoreceptor mosaic, allowing the distinction between these disorders based on the cellular phenotype and suggesting different pathomechanisms

High-throughput format for the phenotyping of fungi on solid substrates

Filamentous fungi naturally grow on solid surfaces, yet most genetic and biochemical analyses are still performed in liquid cultures. Here, we report a multiplexing platform using high-throughput photometric continuous reading that allows parallel quantification of hyphal growth and reporter gene expression directly on solid medium, thereby mimicking natural environmental conditions. Using this system, we have quantified fungal growth and expression of secondary metabolite GFP-based reporter genes in saprophytic Aspergillus and phytopathogenic Fusarium species in response to different nutrients, stress conditions and epigenetic modifiers. With this method, we provide not only novel insights into the characteristic of fungal growth but also into the metabolic and time-dependent regulation of secondary metabolite gene expression

A chiral aperiodic monotile

The recently discovered "hat" aperiodic monotile mixes unreflected and reflected tiles in every tiling it admits, leaving open the question of whether a single shape can tile aperiodically using translations and rotations alone. We show that a close relative of the hat -- the equilateral member of the continuum to which it belongs -- is a weakly chiral aperiodic monotile: it admits only non-periodic tilings if we forbid reflections by fiat. Furthermore, by modifying this polygon's edges we obtain a family of shapes called Spectres that are strictly chiral aperiodic monotiles: they admit only chiral non-periodic tilings based on a hierarchical substitution system.Comment: 23 pages, 12 figure

An aperiodic monotile

A longstanding open problem asks for an aperiodic monotile, also known as an "einstein": a shape that admits tilings of the plane, but never periodic tilings. We answer this problem for topological disk tiles by exhibiting a continuum of combinatorially equivalent aperiodic polygons. We first show that a representative example, the "hat" polykite, can form clusters called "metatiles", for which substitution rules can be defined. Because the metatiles admit tilings of the plane, so too does the hat. We then prove that generic members of our continuum of polygons are aperiodic, through a new kind of geometric incommensurability argument. Separately, we give a combinatorial, computer-assisted proof that the hat must form hierarchical -- and hence aperiodic -- tilings.Comment: 89 pages, 57 figures; Minor corrections, renamed "fylfot" to "triskelion", added the name "turtle", added references, new H7/H8 rules (Fig 2.11), talk about reflection