6,732 research outputs found
Private Graphon Estimation for Sparse Graphs
We design algorithms for fitting a high-dimensional statistical model to a
large, sparse network without revealing sensitive information of individual
members. Given a sparse input graph , our algorithms output a
node-differentially-private nonparametric block model approximation. By
node-differentially-private, we mean that our output hides the insertion or
removal of a vertex and all its adjacent edges. If is an instance of the
network obtained from a generative nonparametric model defined in terms of a
graphon , our model guarantees consistency, in the sense that as the number
of vertices tends to infinity, the output of our algorithm converges to in
an appropriate version of the norm. In particular, this means we can
estimate the sizes of all multi-way cuts in .
Our results hold as long as is bounded, the average degree of grows
at least like the log of the number of vertices, and the number of blocks goes
to infinity at an appropriate rate. We give explicit error bounds in terms of
the parameters of the model; in several settings, our bounds improve on or
match known nonprivate results.Comment: 36 page
Exploiting neutron-rich radioactive ion beams to constrain the symmetry energy
The Modular Neutron Array (MoNA) and 4 Tm Sweeper magnet were used to measure
the free neutrons and heavy charged particles from the radioactive ion beam
induced 32Mg + 9Be reaction. The fragmentation reaction was simulated with the
Constrained Molecular Dynamics model(CoMD), which demonstrated that the
of the heavy fragments and free neutron multiplicities were observables
sensitive to the density dependence of the symmetry energy at sub-saturation
densities. Through comparison of these simulations with the experimental data
constraints on the density dependence of the symmetry energy were extracted.
The advantage of radioactive ion beams as a probe of the symmetry energy is
demonstrated through examination of CoMD calculations for stable and
radioactive beam induced reactions
Similarity based cooperation and spatial segregation
We analyze a cooperative game, where the cooperative act is not based on the
previous behaviour of the co-player, but on the similarity between the players.
This system has been studied in a mean-field description recently [A. Traulsen
and H. G. Schuster, Phys. Rev. E 68, 046129 (2003)]. Here, the spatial
extension to a two-dimensional lattice is studied, where each player interacts
with eight players in a Moore neighborhood. The system shows a strong
segregation independent on parameters. The introduction of a local conversion
mechanism towards tolerance allows for four-state cycles and the emergence of
spiral waves in the spatial game. In the case of asymmetric costs of
cooperation a rich variety of complex behavior is observed depending on both
cooperation costs. Finally, we study the stabilization of a cooperative fixed
point of a forecast rule in the symmetric game, which corresponds to
cooperation across segregation borders. This fixed point becomes unstable for
high cooperation costs, but can be stabilized by a linear feedback mechanism.Comment: 7 pages, 9 figure
Spiking Neurons Learning Phase Delays
Time differences between the two ears are an important cue for animals to azimuthally locate a sound source. The first binaural brainstem nucleus, in mammals the medial superior olive, is generally believed to perform the necessary computations. Its cells are sensitive to variations of interaural time differences of about 10 μs. The classical explanation of such a neuronal time-difference tuning is based on the physical concept of delay lines. Recent data, however, are inconsistent with a temporal delay and rather favor a phase delay. By means of a biophysical model we show how spike-timing-dependent synaptic learning explains precise interplay of excitation and inhibition and, hence, accounts for a physical realization of a phase delay
CK2 Inhibitors Increase the Sensitivity of HSV-1 to Interferon-β
Herpes simplex virus type 1 (HSV-1) requires the activities of cellular kinases for efficient replication. The host kinase, CK2, has been shown or is predicted to modify several HSV-1 proteins and has been proposed to affect one or more steps in the viral lifecycle. Furthermore, potential cellular and viral substrates of CK2 are involved in antiviral pathways and viral counter-defenses, respectively, suggesting that CK2 regulates these processes. Consequently, we tested whether pharmacological inhibitors of CK2 impaired HSV-1 replication, either alone or in combination with the cellular antiviral factor, interferon-β (IFN-β). Our results indicate that the use of CK2 inhibitors results in a minor reduction in HSV-1 replication but enhanced the inhibitory effect of IFN-β on replication. This effect was dependent on the HSV-1 E3 ubiquitin ligase, infected cell protein 0 (ICP0), which impairs several host antiviral responses, including that produced by IFN-β. Inhibitors of CK2 did not, however, impede the ability of ICP0 to induce the degradation of two cellular targets: the promyelocyticleukemia protein (PML) and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Notably, this effect was only apparent for HSV-1, as the CK2 inhibitors did not enhance the antiviral effect of IFN-β on either vesicular stomatitis virus or adenovirus type 5. Thus, our data suggest that the activity of CK2 is required for an early function during viral infection that assists the growth of HSV-1 in IFN-β-treated cells
hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling
Primary cells are often used to study viral replication and host-virus interactions as their antiviral pathways have not been altered or inactivated; however, their use is restricted by their short lifespan. Conventional methods to extend the life of primary cultures typically utilize viral oncogenes. Many of these oncogenes, however, perturb or inactivate cellular antiviral pathways, including the interferon (IFN) response. It has been previously shown that expression of the telomerase reverse transcriptase (TERT) gene extends the life of certain cell types. The effect that TERT expression has on the innate antiviral response to RNA- and DNA-containing viruses has not been examined. In the current study, we introduced the human TERT (hTERT) gene into a primary human embryonic lung (HEL-299) cell strain, which is known to respond to the type I IFN, IFN-β. We show that the resulting HEL-TERT cell line is capable of replicating beyond 100 population doublings without exhibiting signs of senescence. Treatment with IFN-β resulted in the upregulation of four model IFN stimulated genes (ISGs) in HEL-299 and HEL-TERT cells. Both cell lines supported the replication of herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV) and impaired the replication of both viruses upon IFN-β pretreatment. Introduction of the viral oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequently used to immortalize cells, largely negated this effect. Taken together, our data indicate that expression of hTERT does not alter type 1 IFN signaling and/or the growth of two viruses, making this cell line a useful reagent for studying viral replication and virus-cell interactions.This work was supported in part by grants from the National Institute of Allergy and Infectious Diseases (R01AI72357), the National Center for Research Resources (P20RR016475), and the National Institute of General Medical Sciences (P20GM103418) from the National Institutes of Health
Three-body correlations in the ground-state decay of 26O
Background: Theoretical calculations have shown that the energy and angular
correlations in the three-body decay of the two-neutron unbound O26 can provide
information on the ground-state wave function, which has been predicted to have
a dineutron configuration and 2n halo structure.
Purpose: To use the experimentally measured three-body correlations to gain
insight into the properties of O26, including the decay mechanism and
ground-state resonance energy.
Method: O26 was produced in a one-proton knockout reaction from F27 and the
O24+n+n decay products were measured using the MoNA-Sweeper setup. The
three-body correlations from the O26 ground-state resonance decay were
extracted. The experimental results were compared to Monte Carlo simulations in
which the resonance energy and decay mechanism were varied.
Results: The measured three-body correlations were well reproduced by the
Monte Carlo simulations but were not sensitive to the decay mechanism due to
the experimental resolutions. However, the three-body correlations were found
to be sensitive to the resonance energy of O26. A 1{\sigma} upper limit of 53
keV was extracted for the ground-state resonance energy of O26.
Conclusions: Future attempts to measure the three-body correlations from the
ground-state decay of O26 will be very challenging due to the need for a
precise measurement of the O24 momentum at the reaction point in the target
On the ultra-compact nature of 4U1822-000
We report the discovery of a periodic modulation in the optical lightcurve of
the candidate ultra-compact X-ray binary 4U1822-000. Using time-resolved
optical photometry taken with the William Herschel Telescope we find evidence
for a sinusoidal modulation with a semi-amplitude of 8 percent and a period of
191 min, which is most likely close to the true orbital period of the binary.
Using the van Paradijs & McClintock relation for the absolute magnitude and the
distance modulus allowing for interstellar reddening, we estimate the distance
to 4U1822-000 to be 6.3 kpc. The long orbital period and casts severe doubts on
the ultra-compact nature of 4U1822-000.Comment: 3 pages, 1 figure, accepted by MNRA
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