Laser cooling and control of excitations in superfluid helium

Superfluidity is an emergent quantum phenomenon which arises due to strong interactions between elementary excitations in liquid helium. These excitations have been probed with great success using techniques such as neutron and light scattering. However measurements to-date have been limited, quite generally, to average properties of bulk superfluid or the driven response far out of thermal equilibrium. Here, we use cavity optomechanics to probe the thermodynamics of superfluid excitations in real-time. Furthermore, strong light-matter interactions allow both laser cooling and amplification of the thermal motion. This provides a new tool to understand and control the microscopic behaviour of superfluids, including phonon-phonon interactions, quantised vortices and two-dimensional quantum phenomena such as the Berezinskii-Kosterlitz-Thouless transition. The third sound modes studied here also offer a pathway towards quantum optomechanics with thin superfluid films, including femtogram effective masses, high mechanical quality factors, strong phonon-phonon and phonon-vortex interactions, and self-assembly into complex geometries with sub-nanometre feature size.Comment: 6 pages, 4 figures. Supplementary information attache

Microphotonic Forces From Superfluid Flow

In cavity optomechanics, radiation pressure and photothermal forces are widely utilized to cool and control micromechanical motion, with applications ranging from precision sensing and quantum information to fundamental science. Here, we realize an alternative approach to optical forcing based on superfluid flow and evaporation in response to optical heating. We demonstrate optical forcing of the motion of a cryogenic microtoroidal resonator at a level of 1.46 nN, roughly one order of magnitude larger than the radiation pressure force. We use this force to feedback cool the motion of a microtoroid mechanical mode to 137 mK. The photoconvective forces demonstrated here provide a new tool for high bandwidth control of mechanical motion in cryogenic conditions, and have the potential to allow efficient transfer of electromagnetic energy to motional kinetic energy.Comment: 5 pages, 6 figure

Efficacy of conjoint behavioral consultation in developmental-behavioral pediatric services.

• Purpose: To evaluate the effects of the CBC model in addressing presenting concerns for children across home, school, and health care systems. • What are the general effects of CBC in addressing identified concerns in a medically-referred sample? • How do parents and teachers perceive CBC in terms of its perceived effectiveness and acceptability? • How satisfied are parents and teachers with CBC consultants and services when provided across homeschool- medical settings

Research Notes: Iowa State University, Ames, and United States Department of Agriculture

The male-sterile (female-fertile) mutant ms1 is identified by three characteristic features. Kenworthy et al. (1973) reported occurrence of twin seedlings, at a low frequency. We are reporting the two additional characteristics: failure of cytokinesis following telophase II; and production of twice as many pollen mother cells as are found in male-fertile sibs

Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.

BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. OBJECTIVES: The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. DESIGN: Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). SETTING: Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. PARTICIPANTS: Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. INTERVENTIONS: No interventions were performed. MAIN OUTCOME MEASURES: (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. RESULTS: A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). LIMITATIONS: Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. CONCLUSIONS: We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. FUTURE WORK: A large case-control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information

Accessing and assessing lunar resources with PROSPECT

PROSPECT is a package in development by ESA to assess the in-situ resource potential of lunar regolith. PROSPECT will: obtain sub-surface regolith samples, extract volatiles, identify chemical species, quantify abundances, and characterize isotopes

Searching for potential ice-rich mining sites on the Moon with the Lunar Volatiles Scout

Multiple remote observations have indicated the existence of ice deposits in permanently shadowed regions (PSRs) near the lunar poles, nurturing hopes of possible future resource exploitation. However, the interpretation of the orbital data remains ambiguous and ground truth data is necessary for validation. The Lunar Volatiles Scout (LVS) is an integrated instrument for regolith sampling, gas extraction, and analysis that enables mobile prospecting for lunar volatiles, such as loosely adsorbed water and subsurface ice up to a depth of 10 cm. This study presents results of breadboarding activities using an integrated prototype of the LVS instrument to investigate soil insertion and to demonstrate gas extraction and analysis in thermal vacuum. The required vertical force for LVS insertion into dry and ice-bearing regolith was determined to be less than 15 N and sample-to-sample cross-contamination was found to be negligible. Thermal-vacuum test results proved the successful extraction of water from a hydrated lunar regolith simulant and detection of species across a mass to charge ratio m/z range of 15–200