MgB2 tunnel junctions and 19 K low-noise dc superconducting quantum interference devices

Point contact junctions made from two pieces of MgB2 can be adjusted to exhibit either superconductor-insulator-superconductor (SIS) or superconductor-normal metal-superconductor (SNS) current-voltage characteristics. The SIS characteristics are in good agreement with the standard tunneling model for s-wave superconductors, and yield an energy gap of (2.02 +/- 0.08) meV. The SNS characteristics are in good agreement with the predictions of the resistively-shunted junction model. DC Superconducting QUantum Interference Devices made from two SNS junctions yield magnetic field noise as low as 35 fT/Hz^{1/2} at 19 K.Comment: 4 pages, 4 figure

Response to Amir Attaran

Amir Attaran's Policy Forum raises important points on the poor quality of data for some indicators used to measure progress on the Millennium Development Goals (MDGs), but, sadly, uses these findings to draw the wrong conclusions. The evidence he presents on a small number of indicators is partial, and does not justify his conclusion that the MDGs might become a liability and are doomed to fail. Quite the opposite is the case

EC85-103 Nebraska Fall-Sown Small Grain Variety Tests 1985

Extension Circular 85-103: Nebraska Fall- Sown Small Grain Variety Tests. This circular is a progress report of the variety trials conducted by personnel of the Agronomy Department and the South Central, West Central, and Panhandle Centers

Glomerular cell number in normal subjects and in type 1 diabetic patients

Glomerular cell number in normal subjects and in type 1 diabetic patients.BackgroundThe number of cells in glomeruli has been a challenging measure, especially in human kidneys, with only a small amount of tissue obtained by biopsy. However, the number of cells and their function are important determinants of renal function in health and disease.MethodsModern morphometric techniques have now provided the means to determine the numerical density (Nv) and number (with a measure of glomerular volume) of endothelial cells, mesangial cells, and podocytes in plastic-embedded renal tissue biopsied from nondiabetic subjects (N = 36) and type 1 diabetic patients (N = 46) over an extended age range from childhood through late adult.ResultsNv values for all glomerular cells varied only slightly with age and did not change within the range of glomerular lesions of diabetes studied. Thus, the increase in glomerular volume during childhood to a steady level thereafter was the primary determinant of total glomerular cell number. The number of mesangial cells and endothelial cells increased with age, reflecting the increase in all cells, while the podocytes remained unchanged in number over all ages studied (10 to 69 years). Numbers of total glomerular cells, mesangial cells, and endothelial cells were not changed with diabetes, while podocytes were fewer in number in diabetic patients of all ages, with reduced podocyte numbers even in diabetes of short duration.ConclusionsThe essentially constant glomerular cell density in nondiabetic and diabetic subjects under different circumstances possibly indicates an underlying propensity for the glomerulus to regulate its architecture to maintain a constant number of cells per volume, no matter the size of the glomerulus or the severity of diabetic nephropathy studied in this set of patients. The reductions in podocyte numbers in both younger and older diabetic patients indicate a significant risk for functional abnormalities as diabetic nephropathy progresses. Moreover, these observations do not support the suggestion of marked increases in glomerular cell number (and especially mesangial cells) with the development and progression of diabetic nephropathy

Tricuspid Valve Replacement in a Patient with a Leadless Cardiac Pacemaker: Current Guidelines and Recommendations for Perioperative Management

Leadless cardiac pacemakers were developed to reduce complications associated with conventional transvenous pacemakers. While this technology is still relatively new, devices are increasingly being implanted. The perioperative management of patients with these devices has been underreported; we thus seek to add to the limited body of knowledge of perioperative management of patients with leadless cardiac pacemakers. An elderly female patient with a Micra VR transcatheter pacing system leadless cardiac pacemaker placed for tachycardia-bradycardia syndrome with intermittent complete heart block was scheduled for elective tricuspid valve replacement for severe tricuspid regurgitation. Pacemaker interrogation was performed several hours prior to the scheduled surgery based on the electrophysiologist's availability; the device was kept in its programmed VVIR mode, and the base rate was increased from 60 to 80 beats per minute in anticipation of the upcoming surgery. Upon preoperative evaluation, the anesthesiologist asked that the electrophysiology team be placed on standby intraoperatively due to the concern that either oversensing in the setting of pacemaker dependence and/or undesirable tachycardia from rate-responsive pacing could occur. The surgeon used monopolar electrocautery for the duration of the cardiac surgery. Despite the patient having evidence of pacemaker dependence in the intensive care unit preoperatively, no electromagnetic interference leading to oversensing nor rate modulation was detected during intraoperative electrocardiographic and intraarterial invasive monitoring. Evidence-based guidelines regarding perioperative management specifically of leadless cardiac pacemakers do not exist. As these devices become more prevalent, further evaluation will be paramount to determine whether existing guidelines for perioperative management of conventional transvenous pacemakers apply

Development of a Transition Between an Energy-Absorbing Concrete Barrier and a Rigid Concrete Butress

From 2010 to 2015, MwRSF researchers developed the RESTORE barrier, which is a restorable MASH TL-4 median barrier with a steel and concrete rail supported by elastomer posts and steel skids. The research effort reported herein describes the initial development of a transition from the RESTORE barrier to a rigid TL-4 concrete buttress. The previously-developed RESTORE barrier LS-DYNA model was validated against three full-scale vehicle crash tests. Several design concepts were generated through a series of brainstorming efforts. The primary transition concept consisted of a pin and loop connection between the RESTORE barrier and rigid concrete buttress, which was designed and evaluated with LS-DYNA computer simulation. Vehicle and system behavior were investigated using MASH test designation nos. 4-20, 4-21, and 4-22. Six horizontal gusset plates and drop-down pin allowed for limited deflection and rotation at the transition joint, but provided shear continuity between the two systems. A rounded-edge cover plate mitigated vehicle snag on the transition joint hardware. Eleven impact points were evaluated with each vehicle model to determine critical impact points for use in a future full-scale crash testing program. All occupant risk measures and vehicle stability were within MASH limits. Further design modifications are recommended to limit stresses in the transition joint hardware and to reduce excessive occupant compartment deformation that occurred when the small car impacted the concrete buttress end