Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment

Chemical Composition and In Vitro Cytotoxic and Antimicrobial Activities of the Essential Oil from Leaves of Zanthoxylum monogynum St. Hill (Rutaceae).

Background: The Zanthoxylum monogynum species belongs to the family Rutaceae and is found in Southeast, Midwest, and Northeast Brazil. For this genus several biological activities have been described. Methods: The essential oil (EO) was obtained from the leaves of Zanthoxylum monogynum by hydro-distillation and was analyzed by gas chromatograph and gas chromatograph/mass spectrometry (GC and GC/MS). Also the EO of Z. monogynum was evaluated for in vitro cytotoxic activity against six tumor cell lines and for antimicrobial activity, performing disk diffusion and MIC assays with yeast and bacterial strains. Results: The chemical analysis afforded the identification of 18 components (99.0% of the EO). The major components were found to be citronellol (43.0%) and farnesol (32.0%). The in vitro cytotoxic activity against tumor cell lines, resulted in IC50 values ranging from 11-65 µg/mL against all tested cell lines. Antimicrobial activity of the essential oil was also tested and oil was effective, especially against Cryptococcus sp. yeast. All the tested yeast strains showed at least 90% growth inhibition. Conclusions: the essential oil from leaves of Z. monogynum has a different qualitative and quantitative composition when compared to the composition previously described. Also this EO has significant cytotoxic activity and moderate activity against Cryptococcus sp. and Saccharomyces cereviseae yeasts

Prácticas y creencias culturales acerca del cuidado de niños menores de un año en un grupo de madres de Chocontá, Colombia

Con el propósito de identificar las creencias y prácticas culturales acerca del cuidado infantil que pudieran generar conductas de riesgo para el menor de un año, se desarrolló un estudio exploratorio etnográfico, descriptivo y documental con abordaje cualitativo en el municipio de Chocontá (Colombia) de junio a agosto de 2012. Se realizaron entrevistas no estructuradas a las madres de niños menores de un año que asistieron a consulta externa o urgencias de pediatría del Hospital San Martín de Porres del municipio de Chocontá, para que contaran sus experiencias y conocimientos sobre el cuidado de sus bebés. Los datos obtenidos durante la consulta, y la recolección se agruparon en seis categorías: cuidado general, neurodesarrollo, sistema respiratorio, gastrointestinal, alimentación y otros. Esto se confrontó con la literatura científica pertinente para generar un modo de acción en el que se reestructure, se negocie o se conserve la práctica cultural en cuestión. De las diecinueve actividades identificadas, se recomienda reestructurar diez porque pueden ser una conducta de riesgo para el menor; ocho deben ser negociadas con las madres y cuidadores y una se puede conservar puesto que no afecta la integridad del niño. Se concluyó que las creencias y prácticas culturales son parte fundamental de cualquier comunidad

A Systematic Study on Approaches to deal with the Systems’ Evolution and Customization

System developers often face problems in the maintenance and evolution of software systems when they need to customize products to meet different customers needs, by creating new components and modifying existing source code. In this work, it is presented a comparative analysis of existing approaches that deal with variations in Software Product Lines (LPS) through a rigorous study of the state of the art, observing their applicability to handle customizations

The search for an interdisciplinary and contextualized curriculum from integrated technical education to middle school.

A an?lise da integra??o da disciplina Matem?tica juntamente ?s demais ofertadas no Ensino M?dio Integrado a Educa??o Profissional T?cnica consiste no objetivo deste artigo, que apresenta os resultados de uma pesquisa emp?rica fundamentada em reflex?es de autores que discutem o ensino de Matem?tica e a educa??o profissional de n?vel m?dio. O estudo apontou que existe rela??o entre as disciplinas t?cnicas e a Matem?tica, visto que as primeiras, em alguns casos, necessitam dos conhecimentos da segunda para que seus assuntos sejam apreendidos pelos estudantes. Concluiu-se que ? poss?vel elencar os assuntos de Matem?tica que podem ser ministrados no Ensino M?dio Integrado de forma contextualizada e interdisciplinar, a fim de atender a demanda das disciplinas t?cnicas, da Matem?tica e o objetivo formativo profissional do educando.The analysis of the mathematics discipline integration along with other disciplines offered in the Integrated High School Technical Professional Education is the purpose of this paper, which presents the results of an empirical research based on reflections of authors who discuss mathematics teaching and the secondary level of professionaleducation. The survey showed that there is a relationship between technical subjects and mathematics, since the first, in some cases, require the knowledge of the second so that its content is understood by students. We concluded that it is possible to list the Mathematics subjects that can be taught in the Integrated School in a context and interdisciplinary manner in order to meet the demand of technical disciplines, of mathematics and the professional educational purpose of the course

PET Saúde: Experiência de integração ensino-serviço / PET Saúde: Experience of teaching-service integration

Introdução: O Programa de Educação pelo Trabalho para a Saúde (PET Saúde) tem o objetivo de promover a integração ensino-serviço, no sentido de colaborar com a formação acadêmica dos estudantes e com a educação permanente dos profissionais de saúde. Materiais e Métodos: Participam do programa, acadêmicos de cursos diversos, bem como professores da Universidade e profissionais da rede pública de saúde. A partir de um cronograma foram realizadas atividades com o intuito de identificar demandas nas Unidades Básicas de Saúde (UBS) e traçar estratégias para saná-las. Resultados e Discussão: O PET Saúde tem proporcionado grande troca de experiências entre profissionais e estudantes, e desta forma contribuído com melhorias nos serviços, na formação dos acadêmicos e também na forma de trabalhar dos profissionais de saúde. Demonstrando assim a importância da associação entre a teoria apresentada nas instituições de ensino e as atividades práticas desempenhadas nos serviços. 

Outdoor tourism in the North of Portugal from the perspective of tourist entertainment companies (TEC)

Based on the perception of those responsible for Tourist Entertainment Companies (TEC), the objective of the research is to contribute to the characterization of Outdoor Tourism (OT). Exploratory qualitative research was carried out through 38 in-depth individual interviews. The territory geography, the experiences, and the internal market were considered relevant aspects. In addition, seasonality and climate were identified as significant factors in defining the offer, which can favour the preservation of the environment. Moreover, the risk of the activities was considered low. The interviewees suggested integrating everyone involved in a network to explore the region's potential, as well as to support activities and promote the region. The radical experience, adventure, and getting out of the routine were identified as motivations for the search, as well as contact with nature and the landscape. The research is limited to the North Region of Portugal, and it brings together the most different needs, desires, and expectations for tourism demand. Strengthening OT can favour employability and, consequently, economic and social balance while promotion of the activity can be explored through the customers' previous experience. The evaluations, testimonials, and word of mouth (WOM) being added value that can be optimized through social networks and digital marketing.This project is being carried out within the scope of the TURNOUT Project-Development of Outdoor Tourism of Northern Portugal, POCI-01-0145-ERDF-032289, financed by the European Investment Fund Regional Development (ERDF) through the Operational Program of Competitiveness and Innovation (POCI) and the Foundation for Science and Technology, IP (OE). UNIAG, R&D unit funded by the FCT-Portuguese Foundation for the Development of Science and Technology, Ministry of Science, Technology and Higher Education. “Project Code Reference: UIDB/04752/2020”. This project also thanks to the reviewers of the ICTR21 conference for their improvement inputs to the paper.info:eu-repo/semantics/publishedVersio

Monitoring of outdoor tourism demand. North of Portugal

The Herfindahl-Hirschman Index (HHI) was used in order to understand the tourism competitiveness of the different sub-regions that make up the North Region of Portugal. This index is a measure which helps to analyse market concentration and at the same time determines the competitiveness of the market.Uniag, IPB, IPP, IPVC, Porto e Norte, FCT, Compete 2020, Portugal 2020, União Europeiainfo:eu-repo/semantics/publishedVersio

Fructosamine and glycated hemoglobin as biomarkers of glycemic control in people with type 2 diabetes mellitus and cancer (GlicoOnco study)

Introduction: Glycemic control is important to avoid diabetes complications in individuals with cancer. There is no evidence for HbA1c and fructosamine as reliable biomarkers in these conditions. There are particularities in caring for patients with diabetes and cancer that can alter these biomarkers. Objective: The aim of this study was to evaluate HbA1c and fructosamine as glycemic biomarkers in people with type 2 diabetes and cancer, undergoing clinical or surgical oncological treatment. Methods: The authors conducted a single-center, retrospective analysis with people who have cancer and diabetes. Comparison of glycemic biomarkers (HbA1c, fructosamine, and Self-Monitoring of Blood Glucose [SMBG]) was performed including evaluation in individuals undergoing chemotherapy, using glucocorticoids, with anemia, hypoproteinemia or with reduced estimated Glomerular Filtration Rate (eGFR). Results: There was a strong positive correlation between fructosamine and HbA1c (n = 318, r = 0.66, p < 0.001) in people with diabetes and cancer even in those under chemotherapy (n = 101, r = 0.61, p < 0.001) or using glucocorticoids (n = 96, r = 0.67, p<0.001). There was a strong correlation between HbA1c and fructosamine in subjects with anemia (n = 111, r = 0.66, p < 0.001), hypoproteinemia (n = 54, r = 0.67, p < 0.001), or with eGFR ≥ 60 mL/min/1.73 m2 (n = 189, r = 0.70, p < 0.001), and moderate correlation with hypoalbuminemia (n = 21, r = 0.54, p = 0.001) and with reduced eGFR (n = 67, r = 0.57, p < 0.001). The correlations between fructosamine and HbA1c with SMBG were moderate (n = 164, r = 0.49, p < 0.001; n = 111, r = 0.55, p < 0.001, respectively), strong in subjects undergoing chemotherapy, with hypoalbuminemia or hypoproteinemia, and at least moderate, if eGFR < 60 mL/min/1.73 m2 or with anemia. Conclusions: Fructosamine and HbA1c can be used as glycemic biomarkers in people with diabetes and cancer, even in those with anemia, hypoproteinemia, or undergoing chemotherapy