Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting: PROTEC.

Ensaio clínico PROTEC, Protocolo nº 109MS408Abstract BACKGROUND: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease. OBJECTIVE: The aim is to evaluate the effectiveness of delayed-release dimethyl fumarate (DMF) on disease activity and PROs in patients with RRMS in the clinic. METHODS: PROTEC, a phase 4, open-label, 12-month observational study, assessed annualized relapse rate (ARR), proportion of patients relapsed, and changes in PROs. Newly diagnosed and early MS (≤3.5 EDSS and ≤1 relapse in the prior year) patient subgroups were evaluated. RESULTS: Unadjusted ARR at 12 months post-DMF versus 12 months before DMF initiation was 75% lower (0.161 vs. 0.643, p < 0.0001) overall (n = 1105) and 84%, 77%, and 71% lower in newly diagnosed, ≤3.5 EDSS, and ≤1 relapse subgroups, respectively. Overall, 88% of patients were relapse-free 12 months after DMF initiation (84%, newly diagnosed; 88%, ≤3.5 EDSS; 88%, ≤1 relapse). PRO measures for fatigue, treatment satisfaction, daily living, and work improved significantly over 12 months of DMF versus baseline. CONCLUSION: At 12 months after versus 12 months before DMF initiation, ARR was significantly lower, the majority of patients were relapse-free, and multiple PRO measures showed improvement (overall and for subgroups), suggesting that DMF is effective based on clinical outcomes and from a patient perspective.Clinical trial: A Study Evaluating the Effectiveness of Tecfidera (Dimethyl Fumarate) on Multiple Sclerosis (MS) Disease Activity and Patient-Reported Outcomes (PROTEC), NCT01930708,info:eu-repo/semantics/publishedVersio

Jet tomography

I summarize the recent advances in jet tomographic studies of cold and hot nuclear matter based on perturbative QCD calculations of medium-induced gluon bremsstrahlung. Quantitative applications to ultrarelativistic heavy ion reactions at RHIC indicate the creation of a deconfined state of QCD with initial energy density on the order of 100 times cold nuclear matter density.Comment: Plenary talk given at the seventeenth international conference on Ultra-Relativistic Nucleus-Nucleus Collisions (Quark Matter 2004). 8 pages, 12 figures. Updated references, updated Table

Theoretical Overview Quark Matter '04

The much wider transverse-momentum range accessible in heavy-ion collisions at RHIC and at the LHC allows us to disentangle the dynamics of partonic equilibration from the dynamics of delayed hadronization. This provides a novel tool for testing the equilibration mechanisms underlying QCD thermodynamics. Here, I argue, on the basis of simple formation-time arguments, why this is so, and I review recent theoretical developments in this context.Comment: 12 pages, Latex, 3 eps figures, invited introductory talk at Quark Matter 2004, Oakland, January 11-17, 200

High Energy Nuclear Collisions: Theory Overview

We review some basic concepts of Relativistic Heavy Ion Physics and discuss our understanding of some key results from the experimental program at the Relativistic Heavy Ion Collider (RHIC). We focus in particular on the early time dynamics of nuclear collisions, some result from lattice QCD, hard probes and photons.Comment: 11 pages, 3 figures; delivered at ISNP 2009, published in Praman

Jet Quenching in Heavy Ion Collisions

This review article was prepared for the Landolt-Boernstein volume on Relativisitc Heavy Ion Physics.Comment: Review articel accepted for publication in the Landolt-Boernstein Handbook of Physics, ed. R. Stock. 41 pages LaTex, 7 eps-figure