High-performance designs for fiber-pigtailed quantum-light sources based on quantum dots in electrically-controlled circular Bragg gratings

We present a numerical investigation of directly fiber-coupled hybrid circular Bragg gratings (CBGs) featuring electrical control for operation in the application relevant wavelength regimes around 930 nm as well as the telecom O- and C-band. We use a surrogate model combined with a Bayesian optimization approach to perform numerical optimization of the device performance which takes into account robustness with respect to fabrication tolerances. The proposed high-performance designs combine hCBGs with a dielectric planarization and a transparent contact material, enabling >86% direct fiber coupling efficiency (up to >93% efficiency into NA 0.8) while exhibiting Purcell Factors >20. Especially the proposed designs for the telecom range prove robust and can sustain expected fiber efficiencies of more than $(82.2\pm4.1)^{+2.2}_{-5.5}$% and expected average Purcell Factors of up to $(23.2\pm2.3)^{+3.2}_{-3.0}$ assuming conservative fabrication accuracies. The wavelength of maximum Purcell enhancement proves to be the most affected performance parameter by the deviations. Finally, we show that electrical field strengths suitable for Stark-tuning of an embedded quantum dot can be reached in the identified designs.Comment: Main text including Method section, (15 pages, 5 figures, and 50 references). The data sets and used code in this work is available on Zenodo (see reference in the main text

The relationship between occupational demands and well-being of performing artists: A systematic review

Background: Performing artists are exposed to a range of occupational demands from organisational, interpersonal and intrapersonal sources, which may impact their well-being. The aim of this systematic review was to evaluate and synthesise the literature where researchers have considered the relationship between occupational demands and well-being in performing artists. Methods: A mixed-methods systematic review was conducted including professional and student performing artists. Quantitative, qualitative and mixed-methods study designs were eligible for inclusion in the review. A total of 14 databases were searched from their inception through to October 2017, including MEDLINE, EMBASE and Scopus. Critical appraisal was conducted using the Mixed-Methods Appraisal Tool and results presented as a narrative synthesis. Results: A total of 20 studies were included in the review, comprising of quantitative (n=7), qualitative (n=9) and mixed-methods (n=4) study designs. Several frameworks of occupational stress and well-being were explored in relation to the results. Organisational, social and emotional demands were associated with lower well-being. Conversely, music-making, performance activities and social support were reported to be resources and were related to higher well-being. Conclusion: This systematic review highlights the need for researchers in this field to adopt methodologically robust study designs, which are informed by appropriate theoretical frameworks. The paucity of high quality and theoretically informed research in this area is a hindrance to the development of evidence-based interventions for this population

Approved and experimental small-molecule oncology kinase inhibitor drugs: a mid-2016 overview

Kinase inhibitor research is a comparatively recent branch of medicinal chemistry and pharmacology and the first small-molecule kinase inhibitor, imatinib, was approved for clinical use only 15 years ago. Since then, 33 more kinase inhibitor drugs have received regulatory approval for the treatment of a variety of cancers and the volume of reports on the discovery and development of kinase inhibitors has increased to an extent where it is now difficult—even for those working in the field—easily to keep an overview of the compounds that are being developed, as currently there are 231 such compounds, targeting 38 different protein and lipid kinases (not counting isoforms), in clinical use or under clinical investigation. The purpose of this review is thus to provide an overview of the biomedical rationales for the kinases being targeted on the one hand, and the design principles, as well as chemical, pharmacological, pharmaceutical, and toxicological kinase inhibitor properties, on the other hand. Two issues that are especially important in kinase inhibitor research, target selectivity and drug resistance, as well as the underlying structural concepts, are discussed in general terms and in the context of relevant kinases and their inhibitors

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Mode properties of telecom wavelength InP-based high-(Q/V) L4/3 photonic crystal cavities

Gefördert im Rahmen des Nationalkonsortiums IOP Journal