Factores psicosociales que inciden en el bajo rendimiento académico en los estudiantes de grado sexto de la institución educativa técnica ciudad Ibagué comuna trece año 2012 - 2013.

Diario de campo, entrevista, Meta PlanUn equipo de estudiantes de la facultad de psicología de la UNAD (Universidad Nacional Abierta y a Distancia) inicia en el año 2012 un proyecto de investigación que tiene como centro de estudio, los factores psicosociales que afectan el rendimiento académico de los estudiantes cursantes de grado sexto de la institución educativa técnica ciudad Ibagué comuna trece. Dichos factores psicosociales son enfocados hacia: la familia, docente, motivacional y pares debido a la contextualización en la que se encuentra un estudiante en particular; su entorno del día a día. Los instrumentos de medición para la recolección de datos y observación del caso incluyen entrevistas abiertas, semi-estructuradas y diario de Campo. La investigación se desarrolla en cuatro fases: diseño, ejecución, interpretación y discusión y por último socialización en el orden respectivo. Los datos obtenidos revelan que en la comuna trece del barrio Boquerón de Ibagué, el factor con mayor predominancia en la afectación del rendimiento académico del estudiantado del grado sexto es el Familiar, ya que en un gran porcentaje de los núcleos familiares de estudiantes evaluados, los padres no habitan en sus hogares debido a exigencias laborales de los mismos, así como también se manifiesta carencia de acompañamiento y motivación hacia la parte educativa por lo cual el alumno refleja conflictos disciplinarios producto de sus desequilibrios emocionales, de personalidad, identidad, autonomía ó referente a enfrentarse al mundo e interactuar con asertividad a la sociedad.A team of students from the psychology department of UNAD (National Open University and Distance) initiated in 2012 a research project whose center study, psychosocial factors affecting the academic performance of sixth grade students taking technical educational institution Ibague city commune thirteen. These psychosocial factors are focused on the family, teacher, motivation and peers because of contextualization in which there is a particular student, his everyday environment. Measuring instruments for data collection and observation of the case include open interviews, semi-structured field diary. The research is conducted in four phases: design, execution, interpretation and discussion and finally socialization in the respective order. These data reveal that in the parish thirteen Boquerón Ibague neighborhood, the most predominant factor in affecting academic performance of sixth grade students is the Family, since a large percentage of households of students tested, the parents do not live in their homes due to job demands of them, and also manifest lack of support and motivation toward the education for which the student disciplinary conflicts product reflects their emotional imbalances, personality, identity, autonomy or respect to face the world and interact with society assertiveness

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.

CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus vector genomes at the site of inoculation, in liver, and lymphatic tissues. Continuously produced small amounts of antigen maintain fully active effector CD8(+) T cells, while also allowing for their differentiation into central memory cells. The long-term persistence of adenoviral vectors may be highly advantageous for their use as vaccines against pathogens for which T-cell-mediated protection requires both fully activated T cells for immediate control of virus-infected cells and central memory CD8(+) T cells that, because of their higher proliferative capacity, may be suited best to eliminate cells infected by pathogens that escaped the initial wave of effector T cells