25 research outputs found
Novel drug delivery systems in topical treatment of psoriasis: Rigors and vigors
Psoriasis is a chronic inflammatory skin disorder that may drastically
impair the quality of life of a patient. Among the various modes of
treatments for psoriasis, topical therapy is most commonly used in
majority of patients. The topical formulations based on conventional
excipients could serve the purpose only to a limited extent. With the
advent of newer biocompatible and biodegradable materials like
phospholipids, and cutting-edge drug delivery technologies like
liposomes, solid lipid nanoparticles (SLNs), microemulsions, and
nanoemulsions, the possibility to improve the efficacy and safety of
the topical products has increased manifold. Improved understanding of
the dermal delivery aspects and that of designing and developing
diverse carrier systems have brought in further novelty in this
approach. Substantial efforts and the consequent publications, patents
and product development studies on the subject are the matter of
interest and review of this article. However, majority of the work is
related to the preclinical studies and demands further clinical
assessment in psoriasis patients
Nanostructured Lipid Carriers: A New Paradigm in Topical Delivery for Dermal and Transdermal Applications
Systematic Development of Drug Nanocargos Using Formulation by Design (FbD): An Updated Overview
Nanostructured drug delivery formulations have lately gained enormous attention, contributing to their systematic development. Issuance of quality by design (QbD) guidelines by ICH, FDA, and other federal agencies, in this regard, has notably influenced the overall development of drug products, enabling holistic product and process understanding. Owing to the applicability of QbD paradigms, a science lately christened as formulation by design (FbD) has been dedicated exclusively to QbD-enabled drug product development. Consisting of the principal elements of design of experiments (DoE), quality risk management (QRM), and QbD-enabled product comprehension as the fundamental tools in the implementation of FbD, a variety of drug nanocargos have been successfully developed with FbD paradigms and reported in the literature. FbD aims to produce novel and advanced systems utilizing nominal resources of development time, work effort, and money. A systematic FbD approach envisions the entire developmental path through pivotal milestones of risk assessment, factor screening and optimization (both using appropriate experimental designs), multivariate statistical and optimum search tools, along with response surface modeling, usually employing suitable computer software. The design space is one of the fundamental elements of FbD providing the most sought-after regulatory flexibility to pharma companies, postapproval. The present paper provides a bird's eye view of the fundamental aspects of FbD terminology, methodology, and applications in the development of a wide range of nanocargos, as well as a discussion of trends from both technological and regulatory perspectives
Discriminating polymorph distributions in pharmaceutical tablets using stimulated Raman scattering microscopy
Phospholipid microemulsion-based hydrogel for enhanced topical delivery of lidocaine and prilocaine: QbD-based development and evaluation
Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model
Lysine-Based C<sub>60</sub>-Fullerene Nanoconjugates for Monomethyl Fumarate Delivery: A Novel Nanomedicine for Brain Cancer Cells
In
the present study, water-soluble lysine-based C<sub>60</sub>-fullerene
nanoconjugates (CF-LYS-TEG-MMF) were synthesized using
a biodegradable linker for the better delivery of monomethyl fumarate
(MMF) employing Prato reaction. CF-LYS-TEG-MMF resulted in enhanced
cytotoxicity on neuroblastoma cells, meanwhile found to be substantially
biocompatible to erythrocytes. The designed nanoconjugate exhibited
a pH-based drug release pattern, minimizing the leaching of drug at
plasma pH. However, the carrier offered maximum drug release at cancer
cell pH, indicating huge promise in internalization of drug molecules
at the site of target. The pharmacokinetics of MMF in rodents was
significantly improved in terms of enhanced bioavailable drug fraction
in the central compartment, reduced drug clearance, elevated plasma
concentrations and prolonged biological residence of drug. Enhanced
in vitro efficacy in SH-SY5Y neuroblastoma cells, improved erythrocyte
compatibility, high drug loading, and conducive pharmacokinetic profile
by CF-LYS-TEG-MMF offers a huge promise in brain drug delivery, dose
reduction, and dosage-regimen alteration for the management of brain
tumors employing MMF
Integrating genomics and genome editing for orphan crop improvement: a bridge between orphan crops and modern agriculture system
ABSTRACTDomestication of orphan crops could be explored by editing their genomes. Genome editing has a lot of promise for enhancing agricultural output, and there is a lot of interest in furthering breeding in orphan crops, which are sometimes plagued with unwanted traits that resemble wild cousins. Consequently, applying model crop knowledge to orphan crops allows for the rapid generation of targeted allelic diversity and innovative breeding germplasm. We explain how plant breeders could employ genome editing as a novel platform to accelerate the domestication of semi-domesticated or wild plants, resulting in a more diversified base for future food and fodder supplies. This review emphasizes both the practicality of the strategy and the need to invest in research that advances our understanding of plant genomes, genes, and cellular systems. Planting more of these abandoned orphan crops could help alleviate food scarcities in the challenge of future climate crises
Stearic acid based, systematically designed oral lipid nanoparticles for enhanced brain delivery of dimethyl fumarate
Enhanced Brain Delivery of Dimethyl Fumarate Employing Tocopherol-Acetate-Based Nanolipidic Carriers: Evidence from Pharmacokinetic, Biodistribution, and Cellular Uptake Studies
Dimethyl
fumarate (DMF) is an approved drug for the management
of relapsing multiple sclerosis. Despite efficacy, DMF is also reported
to be a challenging drug owing to concerns like gastrointestinal tract
flushing, multiple dosing, lower brain permeability, less patient
compliance, and economic hurdles. The present study aims to develop
DMF-tocopherol acetate nanolipidic carrier (NLCs) to enhance brain
permeability and improve the gastric tolerance. The developed DMF-tocopherol
acetate NLCs offered an average size of 69.70 nm, PDI of 0.317, and
a zeta potential of −9.71 mV. Higher drug entrapment (90.12%)
and drug loading (20.13%) assured controlled drug release behavior
both in gastric and intestinal pH. Cellular uptake studies on Caco-2
and SH-SY5Y monolayers confirmed better intestinal absorption and
neuronal uptake of the developed system, which was further corroborated
by the pharmacokinetic and biodistribution studies. The oral bioavailability
was enhanced by 4.09 times and brain availability was substantially
improved vis-à-vis plain drug. The findings are promising and
offer preclinical evidence for better brain availability of DMF, which
can be exploited in the better management of diseases like multiple
sclerosis