Suicidality in somatization and undifferentiated somatoform disorders: A hospital-based study

Aim: The aim of this study is to examine suicidality in patients with somatization and undifferentiated somatoform disorders. Materials and Methods: Suicidality was assessed among 105 consecutive patients diagnosed with somatization disorder or undifferentiated somatoform disorder according to the ICD-10 criteria. The Mini-International Neuropsychiatric Interview-Plus and the Columbia-Suicide Severity Rating Scale were used in the study. Results: In the study sample, 68.6% reported wish to be dead, 37.1% reported of nonspecific active suicidal thoughts, and 1.9% reported active suicidal ideation with specific plan and intent. The most frequent reason for suicidal ideation was to end or stop the pain. Conclusion: This study had revealed that somatization and undifferentiated somatoform disorders have a high risk of self-harm

Topical Valproate Solution for Hair Growth

Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose related. A large number of drugs may interfere with the hair cycle and produce hair loss. We have only a few drugs like Minoxidil, Finasteride used for hair regeneration and both have its own side effects and limitations. In contrast to oral ingestions of valproate causing hair loss, early experiments with topical Valproic acid cream showed hair regeneration. Valproic acid cream is currently unavailable in the market, alternatively, we do have valproate and divalproex solutions available in various strengths which have a potential to be used topically for hair regeneration. The side effects and cost of topical valproate solution could be much less than the available options in the market. Valproate solution topically has the potential to be used for hair growth