Revival and reinpreatation of family heritage: Scene Design Art Work

Предмет докторског уметничког пројекта Оживљавање и реинтерпретација породичног наслеђа: уметничкo делo сценског дизајна, јесте уочавање, истраживање и ревитализација сећања на сопствено порекло и успостављање јасног односа према личном идентитету. Истраживање као исход има уметничко дело сценског дизајна у форми сајт-специфик пројекта „Одласци“, осмишљеног на простору дедовине, чији је циљ да се снажна лична осећања изразе кроз уметничко дело сценског дизајна.Predmet doktorskog umetničkog projekta Oživljavanje i reinterpretacija porodičnog nasleđa: umetničko delo scenskog dizajna, jeste uočavanje, istraživanje i revitalizacija sećanja na sopstveno poreklo i uspostavljanje jasnog odnosa prema ličnom identitetu. Istraživanje kao ishod ima umetničko delo scenskog dizajna u formi sajt-specifik projekta „Odlasci“, osmišljenog na prostoru dedovine, čiji je cilj da se snažna lična osećanja izraze kroz umetničko delo scenskog dizajna.The subject of the doctoral art project Revival and reinterpretation of family heritage: an artistic work of stage design, is the observation, research and revitalization of existence and revitalization of the identity of relationships based on personality and personality identity. The result of the research is an artistic work of stage design in the form of a site-specific project "Departures", designed in the area of heritage, whose goal is to express strong feelings in a stage art design work

Examination of epidemiological and clinical characteristics of congenital facial and neck anomalies in the pediatric population

Uvod: Urođene anomalije se klinički mogu prezentovati od rođenja do odraslog doba. Nekada je veoma teško razlikovati urođene anomalije od stečenih oboljenja. Ovakav problem se nalazi u diferenciranju lateralnih cista vrata od uvećanih limfnih čvorova. Ciljevi rada: Odrediti relativnu učestalost anomalija lica i vrata analizom dokumentacije pacijenata hospitalizovanih na Odeljenju za plastičnu i rekonstruktivnu hirurgiju Instituta za zdravstvenu zaštitu majke i deteta Srbije „Dr Vukan Čupić”. Odrediti dijagnostičke vrednosti aspiracione biopsije u postavljanju tačne dijagnoze cističnih anomalija lica i vrata. Porediti uputne, kliničke, preoperativne, intraoperativne i histopatološke dijagnoze sa konačnom dijagnozom anomalija lica i vrata. Materijal i metode: U studiji preseka analizirani su podaci pacijenata sa anomalijama lica i vrata hirurški lečenih u periodu od 10 godina (1.7.2009.-30.6.2019.). U analizu je uključeno 1363 pacijenta sa urođenim anomalijama i 205 pacijenata sa stečenim oboljenjima. Izračunavala se aritmetička srednja vrednost i standardna devijacija, mediana i interkvartilni opseg. Razlika distribucija frekvencija između ispitivanih grupa određivala se primenom X²-testa. Koristili su se parametrijski ili neparametrijski testovi za procenu razlika unutar i između grupa (Studentov T-test, Mann-Whitney test). Rezultati: Na licu je dijagnostikovano 1.016 anomalija (64,8%), od kojih su najčešći orofacijalni rascepi (38,9%). Na prednjoj strani vrata lečene su 183 anomalije (medijalna (tiroglosna) cista 68,3% i (epi)dermoidna cista 25,5%), na bočnoj strani vrata 369 anomalija i to 16,8% u nivou gornje polovine sternokleidomastoidnog (SCM) mišića (lateralna cista 38,7%), u visini donje polovine SCM mišića 29,5% (lateralni sinus vrata porekla II ždrelnog luka 23,9%), iza SCM mišića 13,6% (limfatična malformacija (LM) 34%), parotidno 22,8% (LM 42,9%) i supraklavikularno 17,3% (Hodžkinov limfom i LM sa po 28,1%). Najčešće primenjivana radiološka metoda je ultrazvuk. Aspiraciona biopsija je rađena kod 82,1% pacijenata sa cističnom anomalijom (lateralne ciste, LM, venske i mešovite vaskularne malformacije). Zaključak: Najčešće urođene cervikofacijalne anomalije su rascepi usne i nepca. Od potkožnih lezija na licu su najčešće supraorbitalne (epi)dermoidne ciste, a na vratu medijalne (tiroglosne) ciste. Za postavljanje dijagnoze medijalne ciste vrata i (epi)dermoidne ciste dovoljni su anamneza, fizikalni i ultrazvučni pregled. Aspiraciona biopsija je značajna dijagnostička procedura kod cističnih lezija (limfatične i venske malformacije, lateralne ciste vrata). Preoperativne i intraoperativne hirurgove dijagnoze su značajno preciznije od uputnih, posebno ukoliko ih postavlja iskusan hirurg iz oblasti hirurgije lica i vrata u dečijem uzrastu, čak i sa manje primenjenih dijagnostičkih metoda.Introduction: Congenital anomalies can be clinically presented from birth to adulthood. Sometimes it is very difficult to distinguish congenital anomalies from acquired diseases. This problem is in the differentiation of lateral neck cysts from enlarged lymph nodes. Objectives: To determine the relative frequency of facial and neck anomalies by analyzing the documentation of patients hospitalized at the Department of plastic and reconstructive surgery of the Institute for Mother and Child Health Care of Serbia „Dr Vukan Cupic". To determine the diagnostic values of fine needle aspiration biopsy in making an accurate diagnosis of cystic anomalies of the face and neck. Comparison in referral, clinical, preoperative, intraoperative and histopathological diagnoses with the final diagnosis of facial and neck anomalies. Material and methods: The cross-sectional study analyzed data from patients with facial and neck anomalies surgically treated over a period of 10 years (1.7.2009-30.6.2019). The analysis included 1363 patients with congenital anomalies and 205 patients with acquired diseases. Mean and standard deviation, minimum and maximum value of monitored parameters, median and interquartile range were calculated. The difference in frequency distributions between the examined groups was determined using the X²-test. Parametric or non-parametric tests were used to assess differences within and between groups (Student's T-test, Mann-Whitney test). Results: Patients had 1,016 facial anomalies (64.8%), most often orofacial clefts (38.9%). The anterior side of the neck was the localization of 183 anomalies (thyroglossal cyst 68.3% and (epi)dermoid cyst 25.5%), on the lateral side of the neck 369 anomalies, 16.8% in the upper half region of the sternocleidomastoid (SCM) muscle (lateral cyst 38.7%), in the lower half region of the SCM muscle 29.5% (second branchial cleft sinus 23.9%), posterior to the SCM muscle 13.6% (lymphatic malformation (LM) 34%), in the parotid region 22.8% (LM 42.9) and supraclavicular region 17.3% (Hodgkin's lymphoma and LM with 28.1% each). The most commonly used radiological method is ultrasound. Aspiration biopsy was performed in 82.1% of patients with cystic mass (lateral cysts, LM, venous and mixed vascular malformations). Conclusion: The most common congenital cervicofacial anomalies are orofacial clefts. The most common subcutaneous lesions on the face are supraorbital (epi)dermoid cysts, and on the neck thyroglossal cysts. Anamnesis, physical and ultrasound examination are sufficient to diagnose thyroglossal and (epi)dermoid cysts. Aspiration biopsy is an important diagnostic procedure for cystic lesions (lymphatic and venous malformations, lateral neck cysts). Preoperative and intraoperative surgeons' diagnoses are significantly more precise than referral diagnoses, especially if they are made by an experienced surgeon in the field of pediatric facial and neck surgery, even with less applied diagnostic methods

Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?

Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes

Drugs with the highest drug expenditure in the Republic of Serbia

Introduction: The policy concerning drugs represents a concentrated effort to achieve better health outcomes for all, with a particular focus on people's access to and rational use of medications. On the basis of pharmacoeconomic analyses, it is possible to modify established prescribing habits, it is possible to influence the creation of guidelines, development strategy and long-term health care planning. Aim: The aim of the work was to determine drugs with the highest expenditure in the Republic of Serbia, and to compare the results obtained in three consecutive years 2016, 2017 and 2018. Also, to analyze which are the most expensive medications listed in the National Register of Medications and what is the trend of changing them. Material and methods: The drug expenditure was monitored using the ATC/DDD methodology. It implies the classification of medications according to the internationally accepted ATC classification of drugs, while DDD, i.e. defined daily dose, is used as a statistical unit for consumption monitoring. The number of DDD/1,000 inhabitants per day provides an insight into how many inhabitants (out of 1,000 of them) used the observed medication and were exposed to its effects during one day. Results: The trend of expenditure of these medications was growing exponentially from 2016 to 2018. The most expensive medications per box are from group J - anti-infective drugs for systemic use and L - antineoplastics and immunomodulators, but their expenditure in the Republic of Serbia is very low. The drugs with the highest price per 1 DDD are: enzymes imiglucerase, laronidase and the biological medication basiliximab in all three years, but considering the indications and rare prescribing, the total cost for these drugs is not high. The largest funds in the Republic of Serbia for the mentioned period were spent on drugs such as: acetylsalicylic acid, paracetamol in combinations, trastuzumab, pantoprazole, amlodipine and rosuvastatin. Comparing the spending on L group of drugs in 2017 compared to 2016, there was a significant increase. Conclusion: The medications with the highest expenditure in the Republic of Serbia are used very little compared to countries with good pharmacotherapy practice. The most expensive drugs are those that are used for special and rare indications, and large amounts of money are not allocated for them as for some cheaper, but more frequently prescribed drugs

Examination of epidemiological and clinical characteristics of congenital facial and neck anomalies in the pediatric population

Uvod: Urođene anomalije se klinički mogu prezentovati od rođenja do odraslog doba. Nekada je veoma teško razlikovati urođene anomalije od stečenih oboljenja. Ovakav problem se nalazi u diferenciranju lateralnih cista vrata od uvećanih limfnih čvorova. Ciljevi rada: Odrediti relativnu učestalost anomalija lica i vrata analizom dokumentacije pacijenata hospitalizovanih na Odeljenju za plastičnu i rekonstruktivnu hirurgiju Instituta za zdravstvenu zaštitu majke i deteta Srbije „Dr Vukan Čupić”. Odrediti dijagnostičke vrednosti aspiracione biopsije u postavljanju tačne dijagnoze cističnih anomalija lica i vrata. Porediti uputne, kliničke, preoperativne, intraoperativne i histopatološke dijagnoze sa konačnom dijagnozom anomalija lica i vrata. Materijal i metode: U studiji preseka analizirani su podaci pacijenata sa anomalijama lica i vrata hirurški lečenih u periodu od 10 godina (1.7.2009.-30.6.2019.). U analizu je uključeno 1363 pacijenta sa urođenim anomalijama i 205 pacijenata sa stečenim oboljenjima. Izračunavala se aritmetička srednja vrednost i standardna devijacija, mediana i interkvartilni opseg. Razlika distribucija frekvencija između ispitivanih grupa određivala se primenom X²-testa. Koristili su se parametrijski ili neparametrijski testovi za procenu razlika unutar i između grupa (Studentov T-test, Mann-Whitney test). Rezultati: Na licu je dijagnostikovano 1.016 anomalija (64,8%), od kojih su najčešći orofacijalni rascepi (38,9%). Na prednjoj strani vrata lečene su 183 anomalije (medijalna (tiroglosna) cista 68,3% i (epi)dermoidna cista 25,5%), na bočnoj strani vrata 369 anomalija i to 16,8% u nivou gornje polovine sternokleidomastoidnog (SCM) mišića (lateralna cista 38,7%), u visini donje polovine SCM mišića 29,5% (lateralni sinus vrata porekla II ždrelnog luka 23,9%), iza SCM mišića 13,6% (limfatična malformacija (LM) 34%), parotidno 22,8% (LM 42,9%) i supraklavikularno 17,3% (Hodžkinov limfom i LM sa po 28,1%). Najčešće primenjivana radiološka metoda je ultrazvuk. Aspiraciona biopsija je rađena kod 82,1% pacijenata sa cističnom anomalijom (lateralne ciste, LM, venske i mešovite vaskularne malformacije). Zaključak: Najčešće urođene cervikofacijalne anomalije su rascepi usne i nepca. Od potkožnih lezija na licu su najčešće supraorbitalne (epi)dermoidne ciste, a na vratu medijalne (tiroglosne) ciste. Za postavljanje dijagnoze medijalne ciste vrata i (epi)dermoidne ciste dovoljni su anamneza, fizikalni i ultrazvučni pregled. Aspiraciona biopsija je značajna dijagnostička procedura kod cističnih lezija (limfatične i venske malformacije, lateralne ciste vrata). Preoperativne i intraoperativne hirurgove dijagnoze su značajno preciznije od uputnih, posebno ukoliko ih postavlja iskusan hirurg iz oblasti hirurgije lica i vrata u dečijem uzrastu, čak i sa manje primenjenih dijagnostičkih metoda.Introduction: Congenital anomalies can be clinically presented from birth to adulthood. Sometimes it is very difficult to distinguish congenital anomalies from acquired diseases. This problem is in the differentiation of lateral neck cysts from enlarged lymph nodes. Objectives: To determine the relative frequency of facial and neck anomalies by analyzing the documentation of patients hospitalized at the Department of plastic and reconstructive surgery of the Institute for Mother and Child Health Care of Serbia „Dr Vukan Cupic". To determine the diagnostic values of fine needle aspiration biopsy in making an accurate diagnosis of cystic anomalies of the face and neck. Comparison in referral, clinical, preoperative, intraoperative and histopathological diagnoses with the final diagnosis of facial and neck anomalies. Material and methods: The cross-sectional study analyzed data from patients with facial and neck anomalies surgically treated over a period of 10 years (1.7.2009-30.6.2019). The analysis included 1363 patients with congenital anomalies and 205 patients with acquired diseases. Mean and standard deviation, minimum and maximum value of monitored parameters, median and interquartile range were calculated. The difference in frequency distributions between the examined groups was determined using the X²-test. Parametric or non-parametric tests were used to assess differences within and between groups (Student's T-test, Mann-Whitney test). Results: Patients had 1,016 facial anomalies (64.8%), most often orofacial clefts (38.9%). The anterior side of the neck was the localization of 183 anomalies (thyroglossal cyst 68.3% and (epi)dermoid cyst 25.5%), on the lateral side of the neck 369 anomalies, 16.8% in the upper half region of the sternocleidomastoid (SCM) muscle (lateral cyst 38.7%), in the lower half region of the SCM muscle 29.5% (second branchial cleft sinus 23.9%), posterior to the SCM muscle 13.6% (lymphatic malformation (LM) 34%), in the parotid region 22.8% (LM 42.9) and supraclavicular region 17.3% (Hodgkin's lymphoma and LM with 28.1% each). The most commonly used radiological method is ultrasound. Aspiration biopsy was performed in 82.1% of patients with cystic mass (lateral cysts, LM, venous and mixed vascular malformations). Conclusion: The most common congenital cervicofacial anomalies are orofacial clefts. The most common subcutaneous lesions on the face are supraorbital (epi)dermoid cysts, and on the neck thyroglossal cysts. Anamnesis, physical and ultrasound examination are sufficient to diagnose thyroglossal and (epi)dermoid cysts. Aspiration biopsy is an important diagnostic procedure for cystic lesions (lymphatic and venous malformations, lateral neck cysts). Preoperative and intraoperative surgeons' diagnoses are significantly more precise than referral diagnoses, especially if they are made by an experienced surgeon in the field of pediatric facial and neck surgery, even with less applied diagnostic methods

Uloga kontrolisanja antikonvulzivne terapije u unapredjivanju kliničkih rezultata na primeru 12 odraslih obolelih od epilepsije

Dans le cadre du contrat de rivière Sourou, un réseau de surveillance de la qualité des eaux souterraines a été mis en place à travers 8 campagnes de prélèvement effectuées de 2006 à 2014. Les échantillons d’eau provenaient de 23 forages et 9 puits localisés dans la vallée du Sourou. Parmi les paramètres physico-chimiques analysés, les concentrations observées en nitrates étaient préoccupantes. Sur les 32 points d’eau analysés, 14 d’entre eux fournissaient une eau contenant des teneurs en nitrates supérieurs à la valeur seuil de potabilité de l’OMS de 50 mg NO3/L, soit 44 % de non-conformité. Des concentrations très élevées, supérieures à 500 mg NO3/L avec un pic à 860 mg/L, ont été observées. Étant donné les importantes variations observées d’un ouvrage à l’autre, une contamination généralisée de la nappe n’était pas envisageable. Un diagnostic, au cas par cas, a permis d’identifier les causes possibles de cette dégradation. Plusieurs pistes de contamination, en lien avec les activités anthropiques, ont été évoquées à proximité des ouvrages : la défécation sauvage animale et humaine, la présence de latrines à fond perdu, des fosses fumières, des dépôts de déchets, des rejets d’eaux usées. Il convient aussi de s’interroger sur l’impact de l’utilisation de la dynamite pour le creusement des ouvrages, celle-ci pouvant laisser dans l’eau des traces de nitrates. Cette eau non potable est cependant utilisée par les populations rurales du Sourou. Plutôt que l’abandon des forages ou puits fortement contaminés, la mise en place de périmètres de protection au sein desquels seraient éliminées les sources de contamination, peut améliorer la situation. Ne faudrait-il pas aussi faire preuve de prudence lors de l’usage d’explosifs nitratés pour le forage de nouveaux ouvrages