La Imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Municipios de Manizales, Pereira, Villa Garzón, Tumaco y Necoclí

Tomando como base las lecturas de la unidad 8,9 y 10 y las posturas de algunos autores, del diplomado de profundización acompañamiento psicosocial en escenarios de violencia, abordaje de contextos desde los enfoques narrativos, el cual se trabaja desde diferentes escenarios, donde tomamos como tema central un relato de vida y esperanza, (Camilo), y el caso de “Peñas Coloradas” una comunidad que fue víctima de violencia y estigmatizada por ser cómplice de actores armados. En el caso se representan imágenes intimidantes que llevan consigo al desplazamiento forzoso y que provocan al individuo una serie de alteraciones en sus metas, daños morales y psicológicos. Cabe resaltar que la violencia en Colombia ha causado daños irreparables en las vidas de muchas personas, provocando rupturas a nivel cultural y familiar. Aunque el proceso de paz abrió una luz de esperanza intentado reparar el tejido social y emocional, por la lucha de la inclusión y reparación integral. El objetivo de este trabajo es adentrarnos desde una perspectiva psicosocial en la búsqueda de soluciones que conlleven al bienestar psicosocial, a través de un enfoque narrativo y resiliente que permita a las victimas superarse y construir su propio futuro.Taking as a basis the readings of unit 8, 9 and 10 and the positions of some authors, of the diploma of in-depth psychosocial accompaniment in violence scenarios, approach to contexts from narrative approaches, which is worked from different scenarios, where we take as central theme a story of life and hope, (Camilo), and the case of "Peñas Coloradas" a community that was a victim of violence and stigmatized for being an accomplice of armed actors. In the case, intimidating images are represented that lead to forced displacement and that cause the individual a series of alterations in their goals, moral and psychological damage. It should be noted that violence in Colombia has caused irreparable damage to the lives of many people, causing cultural and family ruptures. Although the peace process opened a light of hope, trying to repair the social and emotional fabric, through the fight for inclusion and comprehensive reparation. The objective of this work is to enter from a psychosocial perspective in the search for solutions that lead to psychosocial well-being, through a narrative and resilient approach that allows victims to overcome themselves and build their own future

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population