DIAGNOSTICO Y GUIA AMBIENTAL PARA ALOJAMIENTOS TURISTICOS: APLICACIÓN A CABAÑAS EN TANDIL, ARGENTINA

A partir de um diagnóstico das principais problemáticas ambientais de um setor de alojamentos turísticos em uma cidade de Argentina desenho-se uma metodologia para categorizar e diferenciar empresas turísticas de acordo ao grau em que sua operação se acerque a um modelo de sustentabilidade, quanto ao manejo dos recursos naturais , culturais e sociais. O objetivo do trabalho é desenvolver uma guia interactiva que contemple diagnóstico geral e autodiagnóstico simples, normativa e conselhos de práticas para gerar ações ambientais ou sistemas integrais de gestão, parte de considerar que o gestão ambiental é um processo constante. É parte final de um processo que arranca no diagnóstico do setor e de suas problemáticas a escala local, territorial e desde ali desenvolve um processo conducente a estabelecer acordos de sustentabilidade do destino.A partir de un diagnóstico de las principales problemáticas ambientales de un sector de alojamientos turísticos en una ciudad de Argentina se diseño una metodología para categorizar y diferenciar empresas turísticas de acuerdo al grado en que su operación se acerque a un modelo de sostenibilidad, en cuanto al manejo de los recursos naturales, culturales y sociales. El objetivo del trabajo es desarrollar una guía interactiva que contemple diagnóstico general y autodiagnóstico simple, normativa y consejos de prácticas para generar acciones ambientales o sistemas integrales de gestión, parte de considerar que la gestión ambiental es un proceso constante. Es parte final de un proceso que arranca en el diagnóstico del sector y de sus problemáticas a escala local, territorial y desde allí desarrolla un proceso conducente a establecer acuerdos de sustentabilidad del destino

EL ROL DE LOS STAKEHOLDERS EN LAS PRÁCTICAS AMBIENTALES DE UN SECTOR DE ALOJAMIENTOS TURISTICOS: UN ANALISIS DE CASO.

http://dx.doi.org/10.5902/223611705438The article analyzes if the groups of interest (stakeholders) of the companies of cabins in Tandilcan influence the capture of decision to incorporate actions of environmental management. For itthey were realized you interview where was observed that they have small or void influence in theincorporation of environmental practices and that they are determined great part of the decisionsby the market being necessary to reduce links with sectors as the community or service providers.http://dx.doi.org/10.5902/2236117079675438El artículo analiza si los grupos de interés (stakeholders) de las empresas de cabañas en Tandilpueden influir en la toma de decisión de incorporar acciones de gestión ambiental. Para ello serealizaron entrevistas donde se observó que tienen poca o nula influencia en la incorporación deprácticas ambientales y que gran parte de las decisiones están condicionadas por el mercadosiendo necesario estrechar vínculos con sectores como la comunidad o proveedores de servicios.http://dx.doi.org/10.5902/223611705438O artigo analisa se os grupos de interesse (stakeholders) das empresas de cabañas em Tandilpodem influir na tomada de decisão de incorporar acções na gestão ambiental. Para isso serealizaram entrevistas onde se observou que têm pouca ou nula influência na incorporação depráticas ambientais e que grande parte das decisões estão condicionadas pelo mercado sendonecessário estrechar vínculos com sectores como a comunidade ou provedores de serviços

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

A preservación do patrimônio intangible do trabalho mineiro através de meios audiovisuais. Um caso em Argentina

O presente trabalho descreve brevemente um prometo de extensão desenvolvido durante o ano 2010 que aposta a resgatar parte do patrimônio intangible relacionado à atividade mineira da localidade de Sierras Bayas, localizada no sudeste da Provincia de Buenos Aires. O projeto implicou a elaboração de um documental, por parte de alunos da Faculdade de Arte que cursaban cátedras sobre desenho de audiovisuais. Registraram-se formas e práticas de trabalho que se originaram em Itália e foram instaladas em dito lugar por inmigrantes. Em nosso caso esse conhecimento mineiro é representado por uma familia, que se transformam assim em representantes de uma atividade de soma importância para a região e portadores de um valioso patrimônio cultural, tangible e intangible.O presente trabalho descreve brevemente um prometo de extensão desenvolvido durante o ano 2010 que aposta a resgatar parte do patrimônio intangible relacionado à atividade mineira da localidade de Sierras Bayas, localizada no sudeste da Provincia de Buenos Aires. O projeto implicou a elaboração de um documental, por parte de alunos da Faculdade de Arte que cursaban cátedras sobre desenho de audiovisuais. Registraram-se formas e práticas de trabalho que se originaram em Itália e foram instaladas em dito lugar por inmigrantes. Em nosso caso esse conhecimento mineiro é representado por uma familia, que se transformam assim em representantes de uma atividade de soma importância para a região e portadores de um valioso patrimônio cultural, tangible e intangible

SUSTAINABILITY IN TOURISM THROUGH ENVIRONMENTAL EDUCATION APPLIED TO ITINERARIES

The history of the relationship between man’s activities and the environment has not been a harmonious one, and tourism is no exception. This article gives a brief overview of the impacts caused by the tourism, on both the natural environment and built environments, establishing that the only way to avoid, or at least minimize these negative effects is to develop sustainable tourism, seeking socioenvironmental and economic balance. One of the ways of achieving this sustainable development is through environmental education and the theme of didactic itineraries, in particular, is discussed as a form of raising awareness among the tourists concerning the importance of preserving the natural and cultural environment.  </p

La educación ambiental: Un instrumento para el turismo sustentable.

El presente artículo reflexiona sobre el papel que tiene la educación ambiental para el desarrollo de un turismo que sea sustentable, provocando el cambio de actitudes y comportamientos de los turistas, de las empresas y de las autoridades. Pudiendo usar esta estrategia en cualquier modalidad de turismo, fundamentalmente en aquellas que mayores impactos socio-económicos y ambientales producen. Finalmente se presenta un ejemplo a través de itinerarios que incorporan elementos de la educación ambiental