20 research outputs found
Philippine Sea Plate inception, evolution, and consumption with special emphasis on the early stages of Izu-Bonin-Mariana subduction
- Author
- A Deschamps
- A Deschamps
- A Deschamps
- A Deschamps
- A Deschamps
- A Deschamps
- A Deschamps
- A Deschamps
- A Meijer
- A Mizuno
- A Nishizawa
- A Taira
- AI Shemenda
- AJ Crawford
- B Steinberger
- B Taylor
- B Taylor
- B Taylor
- B-Y Kuo
- C DeMets
- C Faccenna
- C Faccenna
- C Faccenna
- C Gaina
- C Kreemer
- C Rangin
- C Rangin
- C Richter
- CE Hall
- CG Macpherson
- CL Mrozowski
- D Forsyth
- D Stüben
- D Zhao
- DE Karig
- DE Karig
- DE Karig
- DE Karig
- DE Karig
- DH Eakin
- DM Hussong
- E Honza
- F Martinez
- F Martinez
- GP Yumul Jr
- H Bijwaard
- H Kao
- H Tokuyama
- H Tokuyama
- H Tokuyama
- J Azema
- J Hawkins
- J Malavieille
- J Ribeiro
- J Toth
- J Whittaker
- J-C Sibuet
- J-O Park
- J-Y Collot
- JA Johnson
- JA Pearce
- JC Ingle Jr
- JF Lebrun
- JG Mitchell
- JH Natland
- JK Weissel
- JM O’Connor
- JV Gardner
- K Fujioka
- K Fujioka
- K Kobayashi
- K Okino
- K Okino
- K Okino
- K Okino
- K Okino
- KM Pacanovsky
- L Cao
- L Johnson
- L Jolivet
- M Asada
- M Gurnis
- M Monzier
- M Pubellier
- M Pubellier
- M Sdrolias
- M Sdrolias
- M Seton
- M Seton
- M-A Gutscher
- MA Cosca
- MK Reagan
- MK Reagan
- N Baker
- N Chamot-Rooke
- O Ishizuka
- O Ishizuka
- O Ishizuka
- O Ishizuka
- O Ishizuka
- P Fryer
- P Fryer
- P Fryer
- P Fryer
- P Fryer
- P Fryer
- P Fryer
- P Wessel
- R Arai
- R Hall
- R Hall
- R Hall
- R Hall
- R Hall
- R Hickey-Vargas
- R Hickey-Vargas
- R Hickey-Vargas
- R Hickey-Vargas
- R Huene von
- R Huene von
- R Huene von
- R McCaffrey
- R McCaffrey
- RJ Arculus
- RJ Stern
- RJ Stern
- RJ Stern
- RJ Stern
- RK Cardwell
- RV Metcalf
- S Dominguez
- S Lallemand
- S Lallemand
- S Lallemand
- S Lallemand
- S Uyeda
- S Uyeda
- S Widiyantoro
- S Zahirovic
- S Zahirovic
- SA Whattam
- SD Lewis
- SE Lallemand
- SE Lallemand
- SE Lallemand
- SE Lallemand
- SE Lallemand
- SE Lewis
- SH Bloomer
- SK Hsu
- T Fujiwara
- T Fujiwara
- T Kato
- T Morishita
- T Sasaki
- T Seno
- T Yamazaki
- T Yamazaki
- TA Meckel
- TA Meckel
- TJ Falloon
- TV Gerya
- TV Gerya
- TV Gerya
- TWC Hilde
- TY Lee
- VS Kamenetsky
- W Leng
- W Leng
- W Leng
- W Spence
- W Wei
- W Wei
- WB Doo
- WD Sharp
- Y Lagabrielle
- Y Lagabrielle
- Y Lagabrielle
- Y Ohara
- Y Ohara
- Y Yamamoto
- Z Huang
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
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- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
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- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
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- Davies M
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- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
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- Dunhurst F
- Dussan Ma
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- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
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- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
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- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
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- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
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- Filho P
- Fintel D
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- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
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- Floro T
- Foerster A
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- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
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- Foster M
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- Fowler V
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- Frankenstein L
- Fratczak M
- Freitas E
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- Fruchter G
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- Fucili A
- Fukuike C
- Fullerton D
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- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
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- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
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- Garcia-Fragoso V
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- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
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- Gilbert J
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- Gits F
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- Goff R
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- Gomez Sanchez J
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- Gonzales D
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- Gotcheva N
- Goudev A
- Gould R
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- Gralow J
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- Gravenhorst-Muenter U
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- Grigaraviciene I
- Grigorova V
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- Grover A
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- Gupta V
- Gutmann J
- Guzman I
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- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
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- Haase F
- Haege R
- Haenel T
- Hage F
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- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
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- Halliwell Tc
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- Han B
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- Hanefeld M
- Hangyal T
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- Hanustiakova A
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- Hardas S
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- Hegedus V
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- Hutchens E
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- Kamensky G
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- Yaoqing H
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- Yilmaz Mb
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
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- Ball A
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- Ballabio M
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- Bandyopadhyay Sk
- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
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- Barnieh W
- Baronio G
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- Barrie A
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- Baseggio M
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- Belvedere A
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- Berry B
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- Beverstock A
- Bhanderi S
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- Bhangu A. Nepogodiev D
- Bhangu A
- Bhangu A
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- Bhargava A
- Biancafarina A
- Biancafarina A
- Bianchi Cl
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- Bilku D
- Birindelli A
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- Birindelli A
- Blackford Od
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- Blanco F
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- Bogdan M
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- Bolger Jc
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- Bolton W
- Bolzon S
- Bond S
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- Bondurri A
- Bonfante P
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- Borg Cm
- Borges Fc
- Borghi F
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- Boshier Pr
- Botelho P
- Bowen J
- Bowerman H
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- Bowman Cr
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- Boyd-Carson H
- Boza K
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- Branagan G
- Bravo-Gutiérrez Af
- Bravo-Gutiérrez Af
- Brennan S
- Brett M
- Brewer H
- Brewer Hk
- Brewer Hk
- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
- Brown M
- Brown Od
- Brown R
- Bruce Js
- Brunelli Db
- Bryan Es
- Buckley-Jones S
- Bukhari W
- Bull C
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- Busuttil A
- Byrne Be
- Byrnes Ck
- Caballero A
- Caldeira Ab
- Caldwell M
- Callan R
- Calussi M
- Calvo H
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- Cameron Fc
- Campagnaro T
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- Campbell U
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- Cannata G
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- Cantafio S
- Capelli P
- Carcoforo P
- Carden Ca
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- Carlucci M
- Carney K
- Caro A
- Carral-Freire M
- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
- Caula C
- Cavallo D
- Cavero A
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- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
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- Cervellera M
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- Chan D
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- Chandratreya N
- Chandratreya N
- Chapman J
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- Charalabopoulos A
- Charalambous Mp
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- Chatzikonstantinou M
- Chatzikonstantinou M
- Chauhan P
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- Cheah Wl
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- Cheng Sa
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- Chessa A
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- Chetta G
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- Chillitupa Cz
- Chimetto A
- Chin My
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- Chitsabesan P
- Chng S
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- Chong B
- Choolani-Bhojwani E
- Choong Jh
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- Chowdhury F
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- Colangelo E
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- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
- Colvin Da
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- Compagnoni B
- Conci S
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- Contine Ac
- Contreras Rg
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- Cormenzana Ob
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- Cortés Gv
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- Cynthia G
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- D'Auria M
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- Danquah-Boateng D
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- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
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- De Marco P
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- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Marchi Ja
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- Dean Ea
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- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
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- Depalma N
- Deserra A
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- Devezas V
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- Dhari Aa
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- García-Granero A
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- García-Novoa A
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- Morowala A
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- Morton Dg
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- Motiwala Fh
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- Navas-Cuéllar Ja
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- Navidad Ms
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- Nazarian S
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- Neagle G
- Neale A
- Neary Pm
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- Newton Rc
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- Ng J
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- Nicol D
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- Olagbaiye O
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- Olivares-Oliver C
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- Padilla-Valverde D
- Paget C
- Pais M
- Pala M
- Palani-Velu Lk
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- Pan Y
- Panagiotopoulos Sp
- Panda N
- Panda N
- Panda N
- Pandey V
- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- Parajó Ae
- Paramasevon Kr
- Pareja-Ciuró F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- Pérez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-García L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- Suárez-Sánchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-González J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
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- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
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- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
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- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
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- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
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- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
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- Wardle Bg
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- Wardle Sd
- Warren O
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- Warusavitarne J
- Watfah J
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- Weatherburn Lw
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- Wensley F
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- Wheeler C
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- Whitehouse P
- Whiteman E
- Whittaker L
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- Wijesundera K
- Wilcox G
- Wilkin R
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- Wilkin R
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- Williams M
- Williams R
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- Wilson Ej
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- Winter Dc
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- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Reply to 'Unclear causes for subduction'
- Author
- Alexandre N. Bandini-Maeder
- Anders McCarthy
- Andrew P. Barth
- Antony Morris
- Cees van der Land
- Clara Sena
- DP McKenzie
- Frank J. Tepley
- Fuqing Jiang
- Gene M. Yogodzinski
- He Li
- Ivan P. Savov
- Kara A. Bogus
- Kathleen M. Marsaglia
- Kyoko Kanayama
- Laureen Drab
- Lorne C. Loudin
- Marco Maffione
- Martin Neuhaus
- Michael Gurnis
- Mohammed H. Aljahdali
- Morihisa Hamada
- Osamu Ishizuka
- Philipp A. Brandl
- Richard J. Arculus
- RJ Arculus
- RJ Hickey-Vargas
- RJ Stern
- Rodrigo do Monte Guerra
- Rosemary Hickey-Vargas
- Sebastién Meffre
- Sev Kender
- T Ishihara
- W Leng
- Y Higuchi
- Yuki Kusano
- Zhaohui Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Arculus et al. reply — Keenan and
Encarnación suggest that the absence of
pre-subduction inception basement in
the drill core data taken from site U1438
raises ambiguity in our conclusion of
spontaneous subduction initiation in the
Izu–Bonin–Mariana system
Variability of protoliths and pressure-temperature conditions of amphibolites from the Ohmachi Seamount (Izu-Bonin-Mariana arc): evidence of a fossil subduction channel in a modern intra-oceanic arc
- Author
- A Ishiwatari
- AI Okay
- C Drăgusanu
- DL Whitney
- G Rebay
- GTR Droop
- H Iwamori
- H Maekawa
- H Ueda
- JP Platt
- K Hirauchi
- K Mezger
- K Niida
- K Okino
- K Yamamoto
- K Yamamoto
- KW Burton
- L Federico
- M Krebs
- M Nakazaki
- M Sneeringer
- M Yuasa
- O Ishizuka
- O Ishizuka
- P Agard
- PH Hamilton
- R Hickey-Vargas
- R Hickey-Vargas
- R Steiger
- RJ Stern
- RJ Stern
- S Guillot
- S Li
- S Maruyama
- S Schwartz
- SH Bloomer
- SL Goldstein
- SM Eggins
- SW Faryad
- SW Faryad
- T Holland
- T Imayama
- T Imayama
- T Ishii
- T Morishita
- T Tsujimori
- TC Hilde
- TV Gerya
- WB Harland
- WG Ernst
- WG Ernst
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Geochemical evidence for enhanced fluid flux due to overlapping subducting plates
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2008
- Field of study
Absorption of gaseous toluene in aqueous solutions of some kinds of fluorocarbon surfactant
- Author
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Geochemistry and petrogenesis of the Yishak Volcanic Sequence, Kudi ophiolite, West Kunlun (NW China): implications for the magmatic evolution in a subduction zone environment
- Author
- A Photiades
- A Polat
- A Yin
- A Zindler
- AC Kerr
- AD Saunders
- AG Hochstaedter
- AJ Crawford
- AJ Crawford
- AJ Stolz
- AMC Sengör
- AW Hofmann
- B Wolde
- C Kincaid
- C Münker
- C Yuan
- C Yuan
- CG Macpherson
- Chao Yuan
- CL Zhang
- CR Stern
- D Elthon
- DA Wyman
- E Sobel
- F Einaudi
- F Mattern
- FG Sajona
- GD Harper
- HR Smithies
- Hui Zhou
- JA Hoogewerff
- JA Pearce
- JA Pfänder
- JB Gill
- JD Woodhead
- JF Dewey
- JH Bédard
- JI Wendt
- JS Yang
- KC Condie
- L Qi
- M Sun
- Mei-Fu Zhou
- MF Thirlwall
- MFJ Flower
- Min Sun
- MJ Defant
- MK Reagan
- MLG Tejada
- MV Portnyagin
- O Müntener
- P Hollings
- P Schiano
- PB Kelemen
- Ph Matte
- R Hickey-Vargas
- R Hickey-Vargas
- RA Coish
- RF Gribble
- RG Coleman
- RJ Stern
- RJ Stern
- RJ Stern
- RL Hickey
- RN Taylor
- S Meffre
- SF Foley
- SJ Piercey
- SM Peacock
- SR Taylor
- T Ishikawa
- T Plank
- T Tanaka
- TC Juster
- TL Grove
- V Bortolotti
- Wenjiao Xiao
- WJ Sivell
- WJ Xiao
- WM Deng
- XC Xiao
- XH Li
- XR Liang
- Y Tamura
- Y Tatsumi
- YS Pan
- YS Pan
- YZ Wang
- ZH Wang
- ZH Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A record of spontaneous subduction initiation in the Izu–Bonin–Mariana arc
- Author
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Reply to \u27Unclear causes for subduction\u27
- Author
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study