Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants

BACKGROUND: Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinetics of daily inositol to select a dose providing serum levels previously associated with benefit, and to learn if accumulation occurred when administered throughout the normal period of retinal vascularization. METHODS: Infants ≤ 29 wk GA (n = 122, 14 centers) were randomized and treated with placebo or inositol at 10, 40, or 80 mg/kg/d. Intravenous administration converted to enteral when feedings were established, and continued to the first of 10 wk, 34 wk postmenstrual age (PMA) or discharge. Serum collection employed a sparse sampling population pharmacokinetics design. Inositol urine losses and feeding intakes were measured. Safety was prospectively monitored. RESULTS: At 80 mg/kg/d mean serum levels reached 140 mg/l, similar to Hallman's findings. Levels declined after 2 wk, converging in all groups by 6 wk. Analyses showed a mean volume of distribution 0.657 l/kg, clearance 0.058 l/kg/h, and half-life 7.90 h. Adverse events and comorbidities were fewer in the inositol groups, but not significantly so. CONCLUSION: Multiple dose inositol at 80 mg/kg/d was not associated with increased adverse events, achieves previously effective serum levels, and is appropriate for investigation in a phase III trial

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Development of musical preference: A comparison of perceived influences

The purpose of this study was to investigate the sources of variation in music preferences as defined by Leblanc (1980, 1982), provide a comprehensive review of literature as it relates to the variables under investigation, and make recommendations for future research in the field of music preference. Participants (N=420) were undergraduate students (n=354) at a large southeastern university and high school students (n=66) in the southeastern United States. A questionnaire was used to collect demographic information and data for this study. Using a Semantic differential, participants to indicated the influence of twenty-one variables on their musical preferences and an open-ended question at the end allowed them to mark any important influences that may have been left off of the questionnaire. Using demographic information participants were placed in unmatched groups for comparison. Results showed stark differences between the groups' responses of certain variables. The most salient of comparisons was made between the groups of Music Major and Non-Music Major, and Musician and Non-Musician. The Music Major and Musician groups rated the variables of Teachers, Quality, Musical Ability, and Musical Training significantly higher. This may be due to the groups' development as musicians, creating a paradigm of influence that is based on musician-oriented variables. Alternately, Non-Music Majors and Non Musicians rated the variables of Mood, Personality, and Incidental Conditioning higher. Unlike the musician-centric paradigm, these groups seemed to base influences on self, social interaction, and emotion. Future research should investigate the relationship of the hierarchy of influential variables between the population of Musician and Non Musician