Advanced techniques for high resolution spectroscopic observations of cosmic gamma-ray sources

An advanced gamma-ray spectrometer that is currently in development is described. It will obtain a sensitivity of 0.0001 ph/sq cm./sec in a 6 hour balloon observation and uses innovative techniques for background reduction and source imaging

Temperature Sensitivity of Surface Channels on High-Purity Germanium Detectors

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Radiation Damage Effects on High-Purity Germanium Detectors

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Spectra of GRB 970228 from the Transient Gamma-Ray Spectrometer

Visible afterglow counterparts have now been detected for two GRBs (970228 and 970508) but are absent, with $L_{opt}/L_{\gamma}$ ratios at least two orders of magnitude lower, for other GRBs, e.g., 970828. The causes of this variation are unknown. Any correspondence which could be discovered between the gamma-ray properties of a GRB and its $L_{opt}/L_{\gamma}$ would be useful, both in determining the GRB mechanisms, and in allocating resources for counterpart searches and studies. This paper presents the gamma-ray spectra of GRB 970228 as measured by the Transient Gamma-Ray Spectrometer and comments on characteristics of this GRB compared to others that do and do not have observable counterparts.Comment: To appear in "Gamma-Ray Bursts", Proceedings of the 4th Huntsville Symposium, 1997, eds. C. Meegan, R. Preece, and T. Koshut, 5 pages, LaTeX (aipproc.sty incl.), 3 figs. (epsfig.sty

TGRS Observation of the Galactic Center Annihilation Line

The TGRS (Transient Gamma-Ray Spectrometer) experiment is a high-resolution germanium detector launched on the WIND satellite on Nov. 1, 1994. Although primarily intended to study gamma-ray bursts and solar flares, TGRS also has the capability of studying slower transients (e.g. x-ray novae) and certain steady sources. We present here results on the narrow 511 keV annihilation line from the general direction of the Galactic Center accumulated over the period Jan. 1995 through Oct. 1995. These results were obtained from the TGRS occultation mode, in which a lead absorber occults the Galactic Center region for 1/4 of each spacecraft rotation, thus chopping the 511 keV signal. The occulted region is a band in the sky of width 16 degrees that passes through the Galactic Center. We detect the narrow annihilation line from the galactic center with flux = $(1.64\pm0.09)\times10^{-3} {photons} {cm}^{-2} {s}^{-1}$. The data are consistent with a single point source at the galactic center, but a distributed source of extent up to ~30 degrees cannot be ruled out. No evidence for temporal variability on time scales longer than 1 month was found.Comment: 11 pages + 5 Postscript figure

A population-based nested case control study on recurrent pneumonias in children with severe generalized cerebral palsy: ethical considerations of the design and representativeness of the study sample

BACKGROUND: In children with severe generalized cerebral palsy, pneumonias are a major health issue. Malnutrition, dysphagia, gastro-oesophageal reflux, impaired respiratory function and constipation are hypothesized risk factors. Still, no data are available on the relative contribution of these possible risk factors in the described population. This paper describes the initiation of a study in 194 children with severe generalized cerebral palsy, on the prevalence and on the impact of these hypothesized risk factors of recurrent pneumonias. METHODS/DESIGN: A nested case-control design with 18 months follow-up was chosen. Dysphagia, respiratory function and constipation will be assessed at baseline, malnutrition and gastro-oesophageal reflux at the end of the follow-up. The study population consists of a representative population sample of children with severe generalized cerebral palsy. Inclusion was done through care-centres in a predefined geographical area and not through hospitals. All measurements will be done on-site which sets high demands on all measurements. If these demands were not met in "gold standard" methods, other methods were chosen. Although the inclusion period was prolonged, the desired sample size of 300 children was not met. With a consent rate of 33%, nearly 10% of all eligible children in The Netherlands are included (n = 194). The study population is subtly different from the non-participants with regard to severity of dysphagia and prevalence rates of pneumonias and gastro-oesophageal reflux. DISCUSSION: Ethical issues complicated the study design. Assessment of malnutrition and gastro-oesophageal reflux at baseline was considered unethical, since these conditions can be easily treated. Therefore, we postponed these diagnostics until the end of the follow-up. In order to include a representative sample, all eligible children in a predefined geographical area had to be contacted. To increase the consent rate, on-site measurements are of first choice, but timely inclusion is jeopardized. The initiation of this first study among children with severe neurological impairment led to specific, unexpected problems. Despite small differences between participants and non-participating children, our sample is as representative as can be expected from any population-based study and will provide important, new information to bring us further towards effective interventions to prevent pneumonias in this population

The genomic and transcriptional landscape of primary central nervous system lymphoma

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidated. Here, we profile and compare the whole-genome and transcriptome landscape of 51 CNS lymphomas (CNSL) to 39 follicular lymphoma and 36 DLBCL cases outside the CNS. We find recurrent mutations in JAK-STAT, NFkB, and B-cell receptor signaling pathways, including hallmark mutations in MYD88 L265P (67%) and CD79B (63%), and CDKN2A deletions (83%). PCNSLs exhibit significantly more focal deletions of HLA-D (6p21) locus as a potential mechanism of immune evasion. Mutational signatures correlating with DNA replication and mitosis are significantly enriched in PCNSL. TERT gene expression is significantly higher in PCNSL compared to activated B-cell (ABC)-DLBCL. Transcriptome analysis clearly distinguishes PCNSL and systemic DLBCL into distinct molecular subtypes. Epstein-Barr virus (EBV)+ CNSL cases lack recurrent mutational hotspots apart from IG and HLA-DRB loci. We show that PCNSL can be clearly distinguished from DLBCL, having distinct expression profiles, IG expression and translocation patterns, as well as specific combinations of genetic alterations

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Funder: Kennedy Trust Rheumatology Research Prize StudentshipFunder: DFG Cluster of Excellence “Precision Medicine in Chronic In-flammation” (PMI; ID: EXC2167)Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: “Ideas” Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNLFunder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421Abstract: Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS