Semigroups of operators on the space of generalized functions exp A′

AbstractThe inductive limit of spaces exppA′, p ϵ N (Pilipović, SIAM J. Math. Anal., 17 1986, 477–484) whose elements have unique orthonormal series expansions with exponential growth rate of the corresponding coefficients is to be studied in the first part of the paper. Then, we determine some semigroups of operators on this space. This enables us to solve some classes of infinite order partial differential equations

Ex vivo gene transfer in the years to come

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials

A q-deformed nonlinear map

A scheme of q-deformation of nonlinear maps is introduced. As a specific example, a q-deformation procedure related to the Tsallis q-exponential function is applied to the logistic map. Compared to the canonical logistic map, the resulting family of q-logistic maps is shown to have a wider spectrum of interesting behaviours, including the co-existence of attractors -- a phenomenon rare in one dimensional maps.Comment: 17 pages, 19 figure

Prospects for Improving Alfalfa Yield Using Genomic- and Phenomic-Based Breeding

Alfalfa (Medicago sativa L.) is a perennial outcrossing legume that is cultivated as an important forage crop in many parts of the world. Yield is the most important trait for profitable alfalfa production, yet over the last 30 years yield improvement in California has stagnated. Current breeding methods focus on recurrent phenotypic selection; however, alternatives incorporating genomic- and phenomic-based information may enhance genetic gain and help to address the lack of yield improvement. Here we attempt to increase the yield potential of alfalfa using genomic selection (GS) in combination with high throughput phenotyping (HTP). A total of 193 families from two closely related elite populations were sown in the greenhouse and transplanted into mini sward plots at two locations near Davis, CA in May 2020. The trial was managed as a high-input system under full irrigation. Families were genotyped and phenotyped for biomass yield by mechanical harvest and a combination of drone and tower-based remote sensors across 12 harvests, 3 in the establishment year (2020), 7 in the first full year of production (2021) and 2 in 2022. Alfalfa yields ranged from 13-27 tonnes DM/hectare/year with a number of half-sib families outperforming popular cultivars in the first 2 years of production. Biomass volume predicted from the drone-based cameras had a moderate prediction accuracy with an overall R2 of 0.55. Some individual harvests reached accuracies as high as 0.85. Genotyping resulted in a dataset with 6,838 SNPs. Allele frequencies were used to generate a relationship matrix for GS. Narrow-sense heritability for dry matter yield was 0.31 and the predictive ability of the GS model was 0.15

Synovial fibroblasts: key players in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. The involvement of immune cells is a general hallmark of autoimmune-related disorders. In this regard, macrophages, T cells and their respective cytokines play a pivotal role in RA. However, the notion that RA is a primarily T-cell-dependent disease has been strongly challenged during recent years. Rather, it has been understood that resident, fibroblast-like cells contribute significantly to the perpetuation of disease, and that they may even play a role in its initiation. These rheumatoid arthritis synovial fibroblasts (RASFs) constitute a quite unique cell type that distinguishes RA from other inflammatory conditions of the joints. A number of studies have demonstrated that RASFs show alterations in morphology and behaviour, including molecular changes in signalling cascades, apoptosis responses and in the expression of adhesion molecules as well as matrix-degrading enzymes. These changes appear to reflect a stable activation of RASFs, which occurs independently of continuous exogenous stimulation. As a consequence, RASFs are no longer considered passive bystanders but active players in the complex intercellular network of R

Solution of gauge theories induced by fundamental representation scalars

Gauge theories induced by scalars in the fundamental representation of the $U(N_c)_{gauge}\times U(N_f)_{global}$ group are investigated in the large $N_c$ and $N_f$ limit. A master field is defined from bilinears of the scalar field following an Eguchi-Kawai type reduction of spacetime. The density function for the master field satisfies an integral equation that can be solved exactly in two dimensions (D=2) and in a convergent series of approximations at $D>2$. While at D=2 the system is in the same phase at all $\epsilon=N_c/N_f$, it undergoes a phase transition at a critical value, $\epsilon_c(D)$, for $D>2$.Comment: 12 pages, LaTe

Osteoclast-independent bone resorption by fibroblast-like cells

To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two separate models (a severe combined immunodeficient mouse coimplantation model and a dentin pit formation assay), these cells produce signs of bone resorption that are similar to those in early osteoclastic resorption. In an animal model of aseptic prosthesis loosening (i.e. intracranially self-stimulated rats), it is shown that these fibroblasts acquire their ability to degrade bone early on in their differentiation. Upon stimulation, such fibroblasts readily release acidic components that lower the pH of their pericellular milieu. Through the use of specific inhibitors, pericellular acidification is shown to involve the action of vacuolar type ATPases. Although fibroblasts, as mesenchymal derived cells, are thought to be incapable of resorbing bone, the present study provides the first evidence to challenge this widely held belief. It is demonstrated that fibroblast-like cells, under pathological conditions, may not only enhance but also actively contribute to bone resorption. These cells should therefore be considered novel therapeutic targets in the treatment of bone destructive disorders