STUDIES OF THE RADIOACTIVE SPRINGS (XXXIII) EFFECT OF RADIOACTIVE THERMAL BATH ON POTASSIUM, CALCIUM, SODIUM, CHLORIDE AND PROTEIN LEVELS IN SERUM

In order to study the effect of radioactive thermal bath on mineral substances in blood, the author bathed rabbits in Misasa Hot Spring (Yamada-Yu) once daily for 5 minutes dnring the successive 3 weeks, and determined potassium, calcium, sodium, chloride and protein levels in serum before and after the bath every week. The radon content of Yamada-Yu was 300-600×10(-10) curies per liter, its water temperature being 42-44°C. at that time. In the early stage of serial baths calcium decreased, and potassium, sodium, chloride and protein content increased. But in the later stage a reversed tendency was recognized. It was concluded that radioactive thermal baths of Misasa had no peculiar effect on mineral substances in rabbit's serum, compared with the effects of the other kinds of thermal bath

AN EXPERIMNTAL STUDY ON THE EFFECT OF MINERAL WATERS UPON THE MOVEMENT OF ISOLATED RABBIT INTESTINE

The author investigated experimentally effect of the Japanese mineral waters (19 thermals and 6 cold springs) and 20 kinds of salt solutions upon the isolated small intestine of rabbit by Magnus' method. Most waters showed a tendency to decrease the longitudinal tonus and the amplitude of the pendulum movement, but a few showed an increasing effect on the amplitude of the pendulum movement. Only few kinds of waters, for example acid vitriol springs and sulfated calcium springs, had an effect characteristic of their chemical classification. Therefore the effect of minesal waters must be judged with the synthetic consideration on the total action of their whole constituents. Concerning the natural radioactive waters in Japan studied this time no peculiar effect was recognized

FLUORINE CONTENT OF THERMAL WATERS IN TOTTORI PREFECTURE AND ITS RELATION TO MOTTLED TOOTH AND GOITER (2nd REPORT)

The fluorine content of 67 samples of mineral waters in Misasa, Asozu, Togo, Hamamura, and Iwai Hot Springs was investigated by Zirconium-Alizarine Sulfonate method. It ranged from 1.5 to 15 mg. per liter, 3-6mg. per liter in the majority. Most of the river and well waters in the same districts contained no measurable amount of fluorifle． In Misasa, Asozu, Togo and Hamamura Hot Springs 68-83 per　cent of the schoolchildren who take thermal waters habitually as drinking water suffer from mottled tooth. On　the contrary 2-10 per cent of the schoolchildren who do not drink thermal waters habitually showed mottled tooth. In Iwai no inhabitant uses thermal water as drinking water, so that the incidence of mottled tooth among them was only 2.8 per cent. Concerning the incidence of struma in the schoolchildren no relationship was proved between the occurrence of mottled tooth or fluorine content of thermal waters

RELATION BETWEEN THE MOTTLED TOOTH, STRUMA AND FLUORINE CONTENT OF DRINKING WATER INVESTIGATION ON BOYS AND GIRLSLIVIING IN YOSIOKA HOT SPRING AND ITS VICINITY,TOTTORI PREFECTURE, JAPAN

In order to stady the relation between the mottled tooth, struma and fluorine content of drinking water, the author investigated the teeth and thyroid glands of school-boys and girls living in Yoshioka Hot Spring and its vicinity, Tottori Plefectue. Yoshioka Hot Spring is a simple thermal with high fluorine content (max. 5mg. per liter). The incidence of the mottled tooth was 51.5 per cent in average. A close relationship was observed between the morbidity of the mottled tooth and high fluorine content of drinking water. But the author noticed also the occurrence of the mottled tooth among the school-children living in the regions where the fluorine content of drinking water proved to be even less than o.1ppm., and the author emphasizes the possibility of the causal factors other tham fluoline. The palpability of thyroid gland was 78.4 per cent in average, but no significant relation was recognized between the struma and fluorine. Between the mottled tooth and struma, no relation was proved as significant, too

A CASE OF CONGENITAL HAEMOLYTIC JAUNDICE

A case of congenital haemolytic jaundice was reported. The patient showed a remarkable improvement shortly after splenectomy. One of his 6 children, a boy of 7 years is still suffering from haemolytic anaemia

A STUDY ON THE INCIDENCE OF STRUMA IN THE CENTRAL DISTRICT OF TOTTORI PREFECTURE JAPAN 3RD REPORT

After 2-3 years from the previous reports, the author reinvestigated the thyroid glands of the grown-up people and of the school children, living in the central district of Tottori Prefecture, where several radio-active hot springs (Misasa, Sekigane and Hamamura) issue. The palpability of the thyroid gland of the grown-up people was 48.6 per cent in average ; this was significantly higher than that of the 1st report. The size of the thyroid gland of the school children has also significantly increased than that of the 2nd report. The influence of the radio-active hot springs upon the thyroid gland was not recognized again

A CASE OF FAMILIAL HAEMOLYTIC ANAEMIA

The author reported a case of typical congenital haemolytic anaemia. The patient was a girl, aged 7. Microcytaemia was also found in her brother and father

TWO CACES OF CHRONIC FOUDOL POISONING

Two cases of chronic Folidol intoxication were described. Both patients complained of oppressive feeling in upper abdomen, breast and head, since exposure to Folidol-spray. Case 1. A farmer aged 21. Two months after Folidol-spraying, investigation revealed a slight fever, a slight hyperchromic anaemia with relative lymphocytosis, achylia gafotrica, a decreased concentration in bile with a few gall-sands and an occasional tenderness on gall-bladder. Bromsulfalein test slightly positive (8%). A hypoglycaemia, hypotension, high sensitivity to pilocarpine, vanished patellar and Achilles tendon reflexes and a positive Sawada test in urine were also observed. None of the treatments given showed a favourable result. Case 2. A farmer, aged 27. Three months after Folidol-spraying, investigation revealed a slight fever, a hypochromic anaemia and a decrease in serum-cholinesterase activity (40%)