On The Buckling of Fiber-Bundle Type Beams

Euler was the first who studied for engineering applications important problem of buckling arising in a simple, monolithic beam loaded axially by a concentrated load. As it has been shown from two solutions of the problem due to Timosenko theory, the elastic foundation increases the critical buckling load of the beam. Starting from the previous classical results, a mechanism to enhance the buckling strength of a cantilevered beam is investigated. In the place of a single, one-element, monolithic cross-section, the use of a bundle of more than one, similar or not, single cross-sections, placed with parallel axes, and staying in free (unilateral) contact along their adjacent boundaries, is proposed

Evaluation of a strengthening approach for existing RC buildings in terms of resilience and cost efficiency

The aim of the present study is to assess the performance of a reinforced concrete (RC) building been retrofitted with a new precast insulated steel and concrete composite sandwich wall. The applied retrofitting method, as well as the selection of the performance level for design have been studied with reference to their impact on the retrofit cost and the estimated cost due to possible earthquake losses. As a case study an existing 8-story RC building has been selected that is strengthened with inverted-V steel bracings as well as with the application of the proposed insulated composite walls, respectively. By applying inelastic dynamic analyses with artificial accelerograms scaled to represent earthquake scenarios with specific probabilities of recurrence, the seismic response of the strengthened structure is defined for each scenario. The results of the aforementioned analyses are being correlated with the earthquake losses based on an established methodology. Eventually, the performance of each retrofit method is determined and then compared with the respective performance of the existing building. The most efficient method is defined by considering both the construction cost and the earthquake losses cost of each earthquake scenario

Passive Control of Bridges

In the design of bridges with large spans, the significant values of the moments at the main deck-structure require very heavy members, either in the case of a beam or a truss deck-structure. In order to minimize the influence of bending moments, several applications of passive control of displacements using cable nets are herein proposed. The base for all the proposed systems is the cables supported beam nets with additional prestressing control on support cables to optimize the structural behavior of the system. The passive control design problem leads to an optimal control problem for structures governed by variational inequalities. In this presentation several bridge systems are proposed and studied as applications of this method

The 5S rDNA family evolves through concerted and birth-and-death evolution in fish genomes: an example from freshwater stingrays

Background: Ribosomal 5S genes are well known for the critical role they play in ribosome folding and functionality. These genes are thought to evolve in a concerted fashion, with high rates of homogenization of gene copies. However, the majority of previous analyses regarding the evolutionary process of rDNA repeats were conducted in invertebrates and plants. Studies have also been conducted on vertebrates, but these analyses were usually restricted to the 18S, 5.8S and 28S rRNA genes. The recent identification of divergent 5S rRNA gene paralogs in the genomes of elasmobranches and teleost fishes indicate that the eukaryotic 5S rRNA gene family has a more complex genomic organization than previously thought. The availability of new sequence data from lower vertebrates such as teleosts and elasmobranches enables an enhanced evolutionary characterization of 5S rDNA among vertebrates.Results: We identified two variant classes of 5S rDNA sequences in the genomes of Potamotrygonidae stingrays, similar to the genomes of other vertebrates. One class of 5S rRNA genes was shared only by elasmobranches. A broad comparative survey among 100 vertebrate species suggests that the 5S rRNA gene variants in fishes originated from rounds of genome duplication. These variants were then maintained or eliminated by birth-and-death mechanisms, under intense purifying selection. Clustered multiple copies of 5S rDNA variants could have arisen due to unequal crossing over mechanisms. Simultaneously, the distinct genome clusters were independently homogenized, resulting in the maintenance of clusters of highly similar repeats through concerted evolution.Conclusions: We believe that 5S rDNA molecular evolution in fish genomes is driven by a mixed mechanism that integrates birth-and-death and concerted evolution

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment