MONITORIA DA DISCIPLINA CÁLCULO E ELETRÔNICA DO CURSO FACEEL

Historicamente, todos os cursos na área de exatas possuem um número grande de reprovação e evasão nos primeiros semestres. Isso ocorre pela deficiência com que os estudantes entram na Universidade com relação às disciplinas básicas do ensino médio, principalmente matemática. Além de existir um desnível entre alunos ingressantes, fazendo com que os discentes que possuem mais dificuldades desistam de seguir adiante. Uma das soluções aplicadas e que tem mostrado ao longo do tempo resultados importantes são as chamadas monitorias. A monitoria é composta por um docente que coordena as atividades e por discentes que tiveram um bom aproveitamento em uma determinada disciplina ou mesmo possuem habilidades em determinados conteúdo. Esses monitores auxiliam seus colegas a adquirir conhecimento adequado e acompanhar o andamento do conteúdo ministrado pelo professor. A monitoria é entendida como um instrumento para a melhoria do ensino da graduação. Todos os cursos de graduação, principalmente na área de exatas, necessitam de projetos de monitoria para as disciplinas que englobam os primeiros semestres. Algumas disciplinas do curso superior de Engenharia da Computação, tais como física, programação, banco de dados e disciplinas que envolvem matemática possuem um alto índice de reprovação. Isso acontece por diversos fatores, entre eles, uma formação básica insuficiente, tendo como consequência tanto a reprovação na disciplina quanto a evasão do curso. Um dos caminhos para resolver esse problema são as monitorias nas disciplinas citadas acima, tendo como objetivo auxiliar os alunos no processo de ensino e aprendizagem. Tendo em vista o número de disciplinas e a quantidade de professores que as ministram fica inviável o acompanhamento individual por parte de cada professor para um aproveitamento do discente. É inegável que o computador é uma importante ferramenta cognitiva [1], isto é, permite ao estudante desenvolver habilidades, interiorizar conhecimentos e organizá-los de modo a construir uma interpretação do mundo que o cerca. Pode-se exemplificar sua interatividade mediante problemas-jogo, tais como os applets, onde o estudante modifica parâmetros e verifica os resultados obtidos, e dessa forma o computador é uma ferramenta que permite organizar e sistematizar informações [2,3]. Segundo Barroso [3] estes objetos educacionais podem ser utilizados tanto presencialmente quanto à distância. A utilização da tecnologia como agente transformador no ensino, tem sido incansavelmente relatada também como instrumento de laboratório [6-7]. Para diminuir o alto custo de construção de experimentos e outras aplicações de eletrônica digital, o Arduino [8] foi construído para promover a interação física entre o ambiente e o computador utilizando dispositivos eletrônicos de forma simples e baseada em softwares e hardwares livres. O objetivo da monitoria, através dos monitores, é auxiliar o professor na orientação de alunos, esclarecendo e tirando dúvidas em atividades de classe e/ou laboratório, identificar as dificuldades enfrentadas pelos alunos da disciplina, discutir as metodologias, conteúdos e ações a serem priorizados e coordenar grupos de trabalho ou estudo, tendo em vista uma melhora da aprendizagem dos discentes.&nbsp

MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

This article shows a novel function for the MAP1B protein, related to the control of actin dynamics through interaction with Tiam1

Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart

Heart failure (HF) involves alterations in metabolism, but little is known about cardiomyopathy-(CM)-specific or diabetes-independent alterations in gene expression of proteins involved in fatty-acid (FA) uptake and oxidation or in calcium-(Ca(2+))-handling in the human heart.RT-qPCR was used to quantify mRNA expression and immunoblotting to confirm protein expression in left-ventricular myocardium from patients with HF (n = 36) without diabetes mellitus of ischaemic (ICM, n = 16) or dilated (DCM, n = 20) cardiomyopathy aetiology, and non-diseased donors (CTL, n = 6).Significant increases in mRNA of genes regulating FA uptake (CD36) and intracellular transport (Heart-FA-Binding Protein (HFABP)) were observed in HF patients vs CTL. Significance was maintained in DCM and confirmed at protein level, but not in ICM. mRNA was higher in DCM than ICM for peroxisome-proliferator-activated-receptor-alpha (PPARA), PPAR-gamma coactivator-1-alpha (PGC1A) and CD36, and confirmed at the protein level for PPARA and CD36. Transcript and protein expression of Ca(2+)-handling genes (Two-Pore-Channel 1 (TPCN1), Two-Pore-Channel 2 (TPCN2), and Inositol 1,4,5-triphosphate Receptor type-1 (IP3R1)) increased in HF patients relative to CTL. Increases remained significant for TPCN2 in all groups but for TPCN1 only in DCM. There were correlations between FA metabolism and Ca(2+)-handling genes expression. In ICM there were six correlations, all distinct from those found in CTL. In DCM there were also six (all also different from those found in CTL): three were common to and three distinct from ICM.DCM-specific increases were found in expression of several genes that regulate FA metabolism, which might help in the design of aetiology-specific metabolic therapies in HF. Ca(2+)-handling genes TPCN1 and TPCN2 also showed increased expression in HF, while HF- and CM-specific positive correlations were found among several FA and Ca(2+)-handling genes

Happiness around the world: A combined etic-emic approach across 63 countries.

What does it mean to be happy? The vast majority of cross-cultural studies on happiness have employed a Western-origin, or "WEIRD" measure of happiness that conceptualizes it as a self-centered (or "independent"), high-arousal emotion. However, research from Eastern cultures, particularly Japan, conceptualizes happiness as including an interpersonal aspect emphasizing harmony and connectedness to others. Following a combined emic-etic approach (Cheung, van de Vijver & Leong, 2011), we assessed the cross-cultural applicability of a measure of independent happiness developed in the US (Subjective Happiness Scale; Lyubomirsky & Lepper, 1999) and a measure of interdependent happiness developed in Japan (Interdependent Happiness Scale; Hitokoto & Uchida, 2015), with data from 63 countries representing 7 sociocultural regions. Results indicate that the schema of independent happiness was more coherent in more WEIRD countries. In contrast, the coherence of interdependent happiness was unrelated to a country's "WEIRD-ness." Reliabilities of both happiness measures were lowest in African and Middle Eastern countries, suggesting these two conceptualizations of happiness may not be globally comprehensive. Overall, while the two measures had many similar correlates and properties, the self-focused concept of independent happiness is "WEIRD-er" than interdependent happiness, suggesting cross-cultural researchers should attend to both conceptualizations

The Role of Inflammatory Mediators in the Pathogenesis of Otitis Media and Sequelae

This review deals with the characteristics of various inflammatory mediators identified in the middle ear during otitis media and in cholesteatoma. The role of each inflammatory mediator in the pathogenesis of otitis media and cholesteatoma has been discussed. Further, the relation of each inflammatory mediator to the pathophysiology of the middle and inner ear along with its mechanisms of pathological change has been described. The mechanisms of hearing loss including sensorineural hearing loss (SNHL) as a sequela of otitis media are also discussed. The passage of inflammatory mediators through the round window membrane into the scala tympani is indicated. In an experimental animal model, an application of cytokines and lipopolysaccharide (LPS), a bacterial toxin, on the round window membrane induced sensorineural hearing loss as identified through auditory brainstem response threshold shifts. An increase in permeability of the blood-labyrinth barrier (BLB) was observed following application of these inflammatory mediators and LPS. The leakage of the blood components into the lateral wall of the cochlea through an increase in BLB permeability appears to be related to the sensorineural hearing loss by hindering K+ recycling through the lateral wall disrupting the ion homeostasis of the endolymph. Further studies on the roles of various inflammatory mediators and bacterial toxins in inducing the sensorineumral hearing loss in otitis media should be pursued

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease

The recommendations listed in this document are, whenever possible, evidence based. An extensive evidence review was conducted as the document was compiled through December 2008. Repeated literature searches were performed by the guideline development staff and writing committee members as new issues were considered. New clinical trials published in peer-reviewed journals and articles through December 2011 were also reviewed and incorporated when relevant. Furthermore, because of the extended development time period for this guideline, peer review comments indicated that the sections focused on imaging technologies required additional updating, which occurred during 2011. Therefore, the evidence review for the imaging sections includes published literature through December 2011

Predição de campo elétrico para TV digital usando Funções de Green diádicas

This work provides a method for the prediction of electric field intensity to Digital TV using the Dyadic Green's function. The Dyadic is a powerful mathematical tool which has symbolic simplicity and robustness, thus enabling some characteristics of the medium (such as permittivity, conductivity and permeability, for example) are considered in developing the electric field model, as well as take into account the anisotropy of the medium. In most related works using the dyadic Green's functions are related in the VHF band. This work will present from basic concepts of dyadic, developing it for the calculation of a model which can predict the electric field to the UHF band, in which systems are Digital TV. A theoretical explanation and mathematical development will be made such that a clear understanding and objective are achieved in the study of dyadic Green's functions, in a part of the theory of electromagnetism Tests were performed to confirm the applicability of the suggested formulation, making simulations that perform a comparison between measured data, from two TV stations located in the city of Belém, and the Okumura-Hata model modified, showing satisfactory results for both frequencies in VHF and UHF.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorEste trabalho oferece um método para a predição da intensidade de campo elétrico para TV Digital utilizando a Função de Green diádica. A Diádica é uma ferramenta matemática eficiente que tem simplicidade simbólica e robustez permitindo, assim, que algumas características do meio (como permissividade, condutividade e permeabilidade, por exemplo) sejam consideradas na elaboração do modelo de campo elétrico, bem como levar em conta a anisotropia do meio. Na maior parte dos trabalhos correlatos, que utilizam as funções de Green diádicas, estão relacionados na faixa de VHF. Este trabalho irá apresentar desde os conceitos básicos das diádicas, desenvolvendo-a para o cálculo de um modelo que permita predizer o campo elétrico para a faixa de UHF, na qual os sistemas de TV Digital se encontram. Uma explanação teórica e um desenvolvimento matemático serão feitos de forma que um entendimento claro e objetivo sejam alcançados no estudo das funções de Green diádicas, numa parte da teoria do eletromagnetismo. Testes foram realizados para confirmar a aplicabilidade da formulação sugerida, fazendo simulações que realizem uma comparação entre os dados medidos, de duas emissoras de TV situadas na cidade de Belém, e o modelo de Okumura-Hata modificado, mostrando resultados satisfatórios, tanto para frequências na faixa de VHF e UHF