Biomarkers in monitoring - a review

Årsliste 2006Biological effects are increasingly used to monitor impacts of contaminants in marine ecosystems. Biomarkers have been defined as ”biochemical, cellular, physiological or behavioural variations in the tissue or body fluids or at the level of whole organism that provide evidence of exposure to chemical pollutants, and may also indicate a toxic effect”. The biomarkers reviewed here were PAH bile metabolites, cytochrome P4501A, glutathione S-transferase, markers for DNA damage (adducts, alkaline unwinding, Comet assay), micronucleus formation, peroxisomal proliferation, acetyl cholinesterase inhibition, metallothionein, vitellogenin and delta-aminolevulinic acid dehydratase. Focus for the review was dose-response relationships, confounding factors, links to population effects, baseline values, assessment criteria and quality assurance for the relevant biomarker. Whereas correlative links to population-relevant effects have been found for some biomarkers, e.g. biomarkers for DNA damage, most biomarkers are generally more useful as markers for possible impacts elsewhere in ecosystems.OL