1,013 research outputs found
A Study of Incarcerated Youth: The Effect of Student Interest on Reading Comprehension and Engagement
Motivating adolescents to read can be a challenge, but motivating incarcerated adolescents to read may be even more of a challenge. Developing readers in residential facilities are often overlooked by traditional classroom teachers, but much can be learned from incarcerated youth and their motivation and engagement. Unfortunately, there is a shortage of research on effective instructional reading practices that motivate and engage incarcerated youth. The existing research primarily examines the impact of literacy on recidivism instead of strategies for motivating and engaging students who are incarcerated. Numerous studies exist that focus on motivation and engagement of reading in traditional classrooms, but these studies are limited when focused on students from the classrooms in juvenile residential centers. This qualitative study examines the influence of high-interest materials on the comprehension of incarcerated youth and the effect of student dispositions on reading engagement. While there was no obvious correlation between high-interest materials and student comprehension scores, the results of the study suggest that mentor/student rapport, vulnerability, high-interest materials, self-efficacy, and value placed on reading all factor into student motivation and engagement
A Study of Incarcerated Youth: The Effect of Student Interest on Reading Comprehension and Engagement
Motivating adolescents to read can be a challenge, but motivating incarcerated adolescents to read may be even more of a challenge. Developing readers in residential facilities are often overlooked by traditional classroom teachers, but much can be learned from incarcerated youth and their motivation and engagement. Unfortunately, there is a shortage of research on effective instructional reading practices that motivate and engage incarcerated youth. The existing research primarily examines the impact of literacy on recidivism instead of strategies for motivating and engaging students who are incarcerated. Numerous studies exist that focus on motivation and engagement of reading in traditional classrooms, but these studies are limited when focused on students from the classrooms in juvenile residential centers. This qualitative study examines the influence of high-interest materials on the comprehension of incarcerated youth and the effect of student dispositions on reading engagement. While there was no obvious correlation between high-interest materials and student comprehension scores, the results of the study suggest that mentor/student rapport, vulnerability, high-interest materials, self-efficacy, and value placed on reading all factor into student motivation and engagement
The three-body recombination of a condensed Bose gas near a Feshbach resonance
In this paper, we study the three-body recombination rate of a homogeneous
dilute Bose gas with a Feshbach resonance at zero temperature. The ground state
and excitations of this system are obtained. The three-body recombination in
the ground state is due to the break-up of an atom pair in the quantum
depletion and the formation of a molecule by an atom from the broken pair and
an atom from the condensate. The rate of this process is in good agreement with
the experiment on Na in a wide range of magnetic fields.Comment: 10 pages, 2 figures, to be published in Phys. Rev.
A Glimpse in the Future of Malignant Mesothelioma Treatment
Malignant mesothelioma (MMe) is a rare neoplasm with few therapeutic options available. The landscape of effective therapy for this disease remained unchanged in the last two decades. Recently, however, the introduction of Immune Checkpoint Inhibitors (ICIs) led to small, but nevertheless, promising improvements. However, many efforts are still needed to radically improve the prognosis of MMe. In this review, we analyze all those therapeutic strategies for MMe that are still in a preclinical or early clinical phase of development. In particular, we focus on novel antiangiogenic drugs and their possible combination with immunotherapy. Furthermore, we describe also more complex strategies such as microRNA-loaded vectors, oncolytic viruses, and engineered lymphocytes
Copper deficiency-associated myelopathy in cryptogenic hyperzincemia: A case report
Copper deficiency syndrome is an underestimated cause of posterior myelitis. We describe the case of a 41-year-old woman, who developed a subacute ataxic paraparesis associated with low back pain. Her 3T spine MRI showed a thin hyperintense FS-Echo T2 longitudinally extensive lesion involving the posterior columns of the cervical cord (from C2 to C6). An extensive diagnostic work-up excluded other causes of myelopathy and blood tests pointed out hypocupremia and mild hyperzincemia. Patients affected by this rare form of oligoelement deficiency typically develop progressive posterior column dysfunction with sensory ataxia and spasticity, sometimes associated with sensori-motor polyneuropathy. Clinical and radiological characteristics of posterior myelopathy due to copper deficiency are briefly reviewed. Physicians should be aware of this condition since a prompt introduction of copper supplementation can avoid progression of the neurological damage. (www.actabiomedica.it)
A Cretaceous carbonate delta drift in the Montagna della Maiella, Italy
The Upper Cretaceous (Campanian\u2013Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is compared to newly discovered contourite drifts in the Maldives. Like the drift deposits in the Maldives, the Orfento Formation fills a channel and builds a Miocene delta-shaped and mounded sedimentary body in the basin that is similar in size to the approximately 350 km 2 large coarse-grained bioclastic Miocene delta drifts in the Maldives. The composition of the bioclastic wedge of the Orfento Formation is also exclusively bioclastic debris sourced from the shallow-water areas and reworked clasts of the Orfento Formation itself. In the near mud-free succession, age-diagnostic fossils are sparse. The depositional textures vary from wackestone to float-rudstone and breccia/conglomerates, but rocks with grainstone and rudstone textures are the most common facies. In the channel, lensoid convex-upward breccias, cross-cutting channelized beds and thick grainstone lobes with abundant scours indicate alternating erosion and deposition from a high-energy current. In the basin, the mounded sedimentary body contains lobes with a divergent progradational geometry. The lobes are built by decametre thick composite megabeds consisting of sigmoidal clinoforms that typically have a channelized topset, a grainy foreset and a fine-grained bottomset with abundant irregular angular clasts. Up to 30 m thick channels filled with intraformational breccias and coarse grainstones pinch out downslope between the megabeds. In the distal portion of the wedge, stacked grainstone beds with foresets and reworked intraclasts document continuous sediment reworking and migration. The bioclastic wedge of the Orfento Formation has been variously interpreted as a succession of sea-level controlled slope deposits, a shoaling shoreface complex, or a carbonate tidal delta. Current-controlled delta drifts in the Maldives, however, offer a new interpretation because of their similarity in architecture and composition. These similarities include: (i) a feeder channel opening into the basin; (ii) an excavation moat at the exit of the channel; (iii) an overall mounded geometry with an apex that is in shallower water depth than the source channel; (iv) progradation of stacked lobes; (v) channels that pinch out in a basinward direction; and (vi) smaller channelized intervals that are arranged in a radial pattern. As a result, the Upper Cretaceous (Campanian\u2013Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is here interpreted as a carbonate delta drift
The effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on the OCT-measured macular choroidal thickness of eyes with proliferative diabetic retinopathy
OBJECTIVES: To investigate the effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on macular choroidal thickness parameters in eyes with high-risk proliferative diabetic retinopathy. METHODS: High-risk proliferative diabetic retinopathy patients undergoing laser treatment were prospectively enrolled in this study. One eye was randomly selected for laser treatment combined with bevacizumab injections, study group, whereas the corresponding eye was subjected to laser treatment alone, control group. Spectral-domain optical coherence tomography with enhanced depth imaging was used to measure the macular choroidal thickness prior to and 1 month after treatment. Measurements in both groups were compared. Clinicaltrials.gov: NCT01389505. RESULTS: Nineteen patients (38 eyes) with a mean±standard deviation age of 53.4±9.3 years were evaluated, and choroidal thickness measurements for 15 patients were used for comparison. The greatest measurement before treatment was the subfoveal choroidal thickness (341.68±67.66 Όm and 345.79±83.66 Όm for the study and control groups, respectively). No significant difference between groups was found in terms of macular choroidal thickness measurements at baseline or after treatment. However, within-group comparisons revealed a significant increase in choroidal thickness parameters in 10 measurements in the study group and in only 5 temporal measurements in the control group when 1-month follow-up measurements were compared to baseline values. CONCLUSIONS: The macular choroidal thickness does not appear to be significantly influenced by laser treatment alone but increases significantly when associated with bevacizumab injections in patients with proliferative diabetic retinopathy and macular edema. Because bevacizumab injections reduce short-term laser pan-retinal photocoagulation-induced macular edema, our findings suggest that the choroid participates in its pathogenesis
Polygalacturonase from Sitophilus oryzae: Possible horizontal transfer of a pectinase gene from fungi to weevils
Endo-polygalacturonase, one of the group of enzymes known collectively as pectinases, is widely distributed in bacteria, plants and fungi. The enzyme has also been found in several weevil species and a few other insects, such as aphids, but not in Drosophila melanogaster, Anopheles gambiae, or Caenorhabditis elegans or, as far as is known, in any more primitive animal species. What, then, is the genetic origin of the polygalacturonases in weevils? Since some weevil species harbor symbiotic microorganisms, it has been suggested, reasonably, that the symbionts' genomes of both aphids and weevils, rather than the insects' genomes, could encode polygalacturonase. We report here the cloning of a cDNA that encodes endo-polygalacturonase in the rice weevil, Sitophilus oryzae (L.), and investigations based on the cloned cDNA. Our results, which include analysis of genes in antibiotic-treated rice weevils, indicate that the enzyme is, in fact, encoded by the insect genome. Given the apparent absence of the gene in much of the rest of the animal kingdom, it is therefore likely that the rice weevil polygalacturonase gene was incorporated into the weevil's genome by horizontal transfer, possibly from a fungus
Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state
Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ERâmitochondria communication and the balance between proâsurvival and proâdeath pathways. In the current study the role of the PDIA1 family member in breast carcinogenesis was investigated by measuring ROS generation, mitochondrial membrane disruption, ATP production and HLAâG protein levels on the surface of the cellular membrane in the presence or absence of PDIA1. The results showed that this enzyme exerted proâapoptotic effects in estrogen receptor (ERα)âpositive breast cancer MCFâ7 and proâsurvival in triple negative breast cancer (TNBC) MDAâMBâ231 cells. ATP generation was upregulated in PDIA1âsilenced MCFâ7 cells and downregulated in PDIA1âsilenced MDAâMBâ231 cells in a manner dependent on the cellular redox status. Furthermore, MCFâ7 and MDAâMBâ231 cells in the presence of PDIA1 expressed higher surface levels of the nonâclassical human leukocyte antigen (HLAâG) under oxidative stress conditions. Evaluation of the METABRIC datasets showed that low PDIA1 and high HLAâG mRNA expression levels correlated with longer survival in both ERαâpositive and ERαânegative stage 2 breast cancer patients. In addition, analysis of the PDIA1 vs. the HLAâG mRNA ratio in the subgroup of the living stage 2 breast cancer patients exhibiting low PDIA1 and high HLAâG mRNA levels revealed that the longer the survival time of the ratio was high PDIA1 and low HLAâG mRNA and occurred predominantly in ERαâpositive breast cancer patients whereas in the same subgroup of the ERαânegative breast cancer mainly this ratio was low PDIA1 and high HLAâG mRNA. Taken together these results provide evidence supporting the view that PDIA1 is linked to several hallmarks of breast cancer pathways including the process of antigen processing and presentation and tumor immunorecognition
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