Comparative effects of immunomodulators on the factors of antiinfection immunity in doxorubicin-induced immunosuppressive model

В опытах на животных изучали сравнительное влияние иммуномодуляторов амиксина, имунофана и полиоксидония на состояние факторов противоинфекционного иммунитета в условиях доксорубициновой модели иммуносупрессии, которая воспроизводилась путем 4-разового еженедельного введения доксорубицина в дозе 5,0 мг/кг. Установлено, что указанные иммуномодуляторы уменьшают негативное влияние доксорубицина на клеточные и гуморальные факторы антивирусной резистентности, сохраняют реактивность организма к вирусной инфекции, усиливая интерферонообразование и реакцию NК-клеток крови в ответ на инфицирование вирусом гриппа А, и существенно снижают летальность животных от вирусной инфекции. Установлены индивидуальные особенности влияния указанных иммуномодуляторов на факторы антивирусной резистентности.A progressive direction of modern pharmacotherapy is search for effective and safe way to reduce immunotoxic effect of doxorubicin without weakening its specific activity. The central role is given to oxidative stress in the mechanisms of cytotoxic and immunotoxic doxorubicin effect, it was logical to study means of prevention immunotoxic effects of this drug among immunomodulators with membranoproteсtor and antioxidant activity. In animal there were examined the relative influence of immunomodulators amixin, imunofan, polyoxidonium and the state of antiinfection immunity factors in doxorubicin immunosuppressive model that was presented by four-times weekly administration of doxorubicin at a dose of 5.0 mg/kg. It was found that after 4-time introduction doxorubicin develops most profound immunosuppression, which is accompanied by a profound inhibition of effector activity of NK-cells of blood, almost complete loss of the ability of the body to respond interferon-induced in response to its infectioning with a sublethal dose of influenza A and 100% mortality of virus-infected animals within first 5 days of observations. It is shown that immunomodulators amixin, imunofan and polyoxidonium with different efficiency reduce the negative impact of doxorubicin on cellular and humoral factors of antiviral resistance, retain reactivity to viral infection, increasing interferonogenesis and NK-cell responses of blood in response to infectioning with influenza A and significantly reduce animals mortality from viral infection